Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep285 | Calcium and Vitamin D metabolism | ECE2015

Low extracellular sodium promotes adipogenic commitment of human mesenchymal stromal cells: a novel mechanism for chronic hyponatremia-induced bone loss

Deledda Cristiana , Fibbi Benedetta , Giuliani Corinna , Benvenuti Susanna , Luciani Paola , Mazzanti Benedetta , Saccardi Riccardo , Peri Alessandro

Hyponatraemia represents an independent risk factor for osteoporosis and fractures, affecting both bone density and quality. A direct stimulation of osteoclastogenesis and bone resorption in the presence of reduced extracellular sodium concentrations ([Na+]) has been shown, but, to date, the effects of reduced [Na+] on osteoblasts have not been elucidated. This study investigated the effects of a chronic reduction of extracellular [Na+], independently of osmotic stress, on hum...

ea0014p530 | (1) | ECE2007

The expression of the neuroprotective factor seladin-1 is up-regulated by thyroid hormones in human neuronal precursor cells, but not in mature neurons

Benvenuti Susanna , Luciani Paola , Cellai Ilaria , Deledda Cristiana , Saccardi Riccardo , Urbani Serena , Vannelli Gabriella B , Francini Fabio , Squecco Roberta , Serio Mario , Pinchera Aldo , Peri Alessandro

Thyroid hormones (TH) play a fundamental role during brain development by modulating the expression of different genes involved in neuronal differentiation, proliferation, migration, myelinization, and synapse formation. Seladin-1 (for SELective Alzheimer’s Disease INdicator-1) is a recently identified anti-apoptotic gene, which has been found to be down-regulated in brain regions affected by Alzheimer’s disease (AD). We hypothesized that seladin-1 might be a ...