ea0029p1588 | Thyroid (non-cancer) | ICEECE2012
Dauth S.
, Rehders M.
, Sirbulescu R.
, Wirth E.
, Braun D.
, Batbajar B.
, Schweizer U.
, Brocker-Preuss M.
, Fuhrer D.
, Saftig P.
, Jordans S.
, Brix K.
Cathepsin K is a cysteine protease known for its importance in bone remodelling. Inhibitors of cathepsin K are in clinical trials for osteoporosis treatment, but side effects included altered levels of related cathepsins in peripheral organs and in the central nervous system (CNS). Importantly, cathepsin K has been identified not only in osteoclasts but also in most epithelia and, recently, in brain parenchyma. Lately, we have also shown that cathepsin K deficiency in mice ind...