Searchable abstracts of presentations at key conferences in endocrinology

ea0090ep713 | Pituitary and Neuroendocrinology | ECE2023

Kisspeptin Kindred: Case Report and Literature Review

Sanpawithayakul Kanokporn , Howard Sasha , Korbonits Marta

Context: Normosmic idiopathic hypogonadotropic hypogonadism (nIHH) is a rare endocrine disease in which patients have isolated gonadotropin releasing hormone (GnRH) deficiency in the context of otherwise normal structure and function of anterior pituitary and hypothalamus with normal olfactory ability.Objective: To explore the underlying pathogenic defect in patients with delayed puberty.Patients: We investigated genetic defects in...

ea0094p363 | Neuroendocrinology and Pituitary | SFEBES2023

Hindering the progression of cardiac fibrosis in acromegaly – the role of somatostatin receptor ligands

Sanpawithayakul Kanokporn , Mistry Anisha , Rai Ashutosh , Funge Gregory , Sebastian Sonia , Solomou Antonia , Lillina Vignola Maria , Gaston-Massuet Carles , Tinker Andrew , Begalli Federica , Korbonits Marta

Introduction: Acromegaly links to cardiomyopathy and potential cardiac failure, if untreated. Mechanisms involved in acromegalic cardiomyopathy are incompletely understood. We investigated the effects of growth hormone (GH) excess and somatostatin receptor ligands (SRLs) on cardiac fibrosis using an acromegalic mouse model with pituitary-specific deletion of the Aip gene coding aryl hydrocarbon receptor interacting protein (AipFlox/Flox;Hesx1<su...