Searchable abstracts of presentations at key conferences in endocrinology

ea0011p781 | Thyroid | ECE2006

Psychological wellbeing correlates with free T4 but not free T3 levels in patients on ‘adequate’ thyroid hormone replacement

Saravanan P , Visser T , Dayan CM

Both thyroid dysfunction and psychological morbidity are common in the general population. Association between mood disorders and overt thyroid dysfunction are well established. Hypothyroid patients are more prone to depression and anxiety is a frequently reported symptom in thyrotoxicosis. However, the relationship between thyroid hormones in the normal range and psychological well being has not been established.In this study we analysed the relationshi...

ea0038p231 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

‘Thin-fat’ phenotype in early foetal life in GDM pregnancies – novel evidence from an Indian Cohort

Venkataraman Hema , Ram Uma , Anuradhai A , Suresh S , Saravanan P

Research question: What are the differences in foetal size in early pregnancy between GDM and control.Methods: Serial foetal biometry was performed for GDM women and controls at 18–20 weeks and 28–32 weeks. At each visit, abdominal and head circumference (AC) & (HC), femur length (FL) and abdominal wall thickness (AWT) was measured along with collection of maternal data.Results: women with GDM and 184 controls had com...

ea0019p357 | Thyroid | SFEBES2009

Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination T4/T3 therapy in patients on thyroid hormone replacement

Panicker V , Saravanan P , Vaidya B , Evans J , Hattersley A , Frayling T , Dayan C

Introduction: There remains considerable debate over combination T4/T3 therapy for thyroid hormone replacement. Whilst large randomised-controlled studies have failed to show benefit over T4 only, there remain patients who feel better on the combination. Animal studies suggest that up to 80% of intracellular T3 in the brain is derived from circulating T4 by local deiodination. We hypothesized that in patients on thyroxine ...

ea0009p220 | Clinical | BES2005

Unusual presentation of multiple endocrine neoplasia 2A

Saravanan P , Goss L , Dunn J , Paisey R , Rankin J , MacLeod K

Multiple Endocrine Neoplasia 2 (MEN2) is a rare, autosomal dominant neuroendocrine tumour. MEN2A is a syndrome of medullary thyroid carcinoma (MTC), pheochromocytoma and parathyroid tumours. MEN2B is characterised by MTC, pheochromocytoma, marfanoid habitus and intestinal & mucosal ganglioneuromas. MEN2 syndromes are due to mutations in the RET proto-oncogene, located near the centromere of the chromosome 10. While the commonest mutations described in MEN2A is in exon 11 (...

ea0007p229 | Thyroid | BES2004

Twenty-four hour hormone profiles of TSH, free T3 and free T4 in hypothyroid patients on combined T3/T4 therapy

Siddique H , Saravanan P , Simmons D , Greenwood R , Peters T , Dayan C

Objective: To determine the 24hour thyroid hormone profile on patients with combined T3/T4 therapy.Methods: Two subgroup of patients (10 on combined T3/T4 (study, S) and 10 T4 alone (control, C) were randomly selected from 697 patients who were already involved in WATTS study, after ethical approval. Prior to study entry all patients were on 100micrograms or more of T4. The study group received 10micrograms of T3 in place of 50micrograms of T4 while the ...

ea0005p266 | Thyroid | BES2003

Psychological well-being in patients on 'adequate' doses of L-Thyroxine

Saravanan P , Chau F , Roberts N , Vedhara K , Greenwood R , Dayan C

Objective: Many patients receiving thyroid hormone replacement therapy complain of persistent lethargy and related symptoms even with normal TSH levels. However, it remains unclear whether this is related to thyroxine replacement or coincidental psychological morbidity.Design: Using general practice computer records, 961 patients on thyroxine (minimum of 4 months) and their age- and sex-matched controls were identified and sent a two-page questionnaire, comprising the shor...