Searchable abstracts of presentations at key conferences in endocrinology

ea0063p32 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

18-oxocortisol synthesis in aldosterone-producing adrenocortical adenoma and significance of KCNJ5 mutation status

Satoh Fumitoshi Yamazaki Yuto , Morimoto Ryo , Kudo Masataka , Gomez-Sanchez Celso E , Ito Sadayoshi , Sasano Hironobu , Satoh Fumitoshi

Peripheral 18-oxocortisol level could contribute to the detection of aldosterone-producing adenoma in patients with primary aldosteronism. However, peripheral 18-oxocortisol varies among such patients, which is a big drawback concerning its clinical application. We studied 48 cases of aldosterone-producing adenoma, 35 harboring KCNJ5 mutation, to clarify the significance of clinical and pathological parameters regarding peripheral 18-oxocortisol. Peripheral 18-oxocort...

ea0049gp14 | Adrenal 2 | ECE2017

Simultaneous assays of aldosterone and renin concentrations in just ten minutes could change the clinical assessment for the diagnosis of primary aldosteronism

Satoh Fumitoshi , Ryo Morimoto , Ono Yoshikiyo , Tezuka Yuta , Omata Kei , Nezu Masahiro , Iwakura Yoshitsugu , Igarashi Yoshuhiro , Kudo Masataka , Ito Sadayoshi

Measurement of plasma aldosterone and renin concentration, or activity, is useful for selecting antihypertensive agents as well as detecting hyperaldosteronism in hypertensive patients. However, it takes several days to get results when measured by radioimmunoassay and development of more rapid assays has been long expected. We have developed chemiluminescent enzyme immunoassays enabling the simultaneous measurement of both aldosterone and renin concentrations in ten-minutes b...

ea0037gp.03.03 | Adrenal (2) | ECE2015

Radiofrequency bipolar ablation therapy for primary aldosteronism patients: investigator-initiated exploratory clinical trial

Takase Kei , Seiji Kazumasa , Morimoto Ryo , Iwakura Yoshizugu , Ono Yoshikiyo , Omata Kei , Kudo Masataka , Kinoshita Tomo , Satoh Fumitoshi , Ito Sadayoshi

Purpose: To evaluate safety and efficacy of percutaneous radiofrequency ablation therapy for unilateral aldosterone producing adrenal adenoma in normalising aldosterone secretion.Patients: Eight cases of aldosterone producing adrenal adenoma with following conditions: i) CT detectable adenoma without any risky organs on a puncture route. ii) Intervening adipose tissue between target adenoma and adjacent risky organs (pancreas or intestine). iii) Unilater...

ea0070aep22 | Adrenal and Cardiovascular Endocrinology | ECE2020

The study of cell senescence in cortisol-producing adrenocortical adenoma

Gao Xin , Yamazaki Yuto , Pieroni Jacopo , Tezuka Yuta , Omata Kei , Ono Yoshikiyo , Morimoto Ryo , Nakamura Yasuhiro , Satoh Fumitoshi , Sasano Hironobu

Introduction: Aging is associated with the pathogenesis of many endocrinological disorders, especially for functioning adrenocortical disorders. In addition, mitochondria DNA abnormalities have been reported to be correlated with aging through ROS which eventually resulted in cell senescence. We previously reported that cortisol-producing adenomas (CPA) expressed more abundant cell senescent markers including p16 and p21, compared to other hormone-producing adenomas. However, ...

ea0056gp26 | Adrenal clinical | ECE2018

Segmental adrenal venous sampling may give a key to solution about the debate of cosyntropin stimulation or not

Satoh Fumitoshi , Tezuka Yuta , Morimoto Ryo , Omata Kei , Ono Yoshikiyo , Igarashi Yasuhiro , Kudo Masataka , Takase Kei , Ito Sadayoshi

Background: Adrenal venous sampling (AVS) is critical to differentiate unilateral primary aldosteronism (PA) subtype. However, there are large discrepancies between institutions in the diagnostic criteria of AVS. Especially, the most major debate is in whether cosyntropin stimulation should be used for localization diagnosis or not. Segmental AVS (S-AVS) is a refinement of central AVS (C-AVS) in which samples are taken from the tributaries of the central adrenal veins allowing...

ea0037ep66 | Adrenal cortex | ECE2015

Clinical significance of contralateral adrenal suppression during adrenal vein sampling in primary aldosteronism

Monticone Silvia , Satoh Fumitoshi , Viola Andrea , Fischer Eveline , Vonend Oliver , Bernini Giampaolo , Quinkler Marcus , Giacchetti Gilberta , Morimoto Ryo , Willemberg Holger , Maccario Mauro , Veglio Franco , Ito Sadayoshi , Reincke Martin , Mulatero Paolo

Objective: Adrenal vein sampling (AVS) is recognised by Endocrine Society guidelines as the only reliable mean to distinguish between aldosterone producing adenomas and bilateral adrenal hyperplasia, the two most common subtypes of primary aldosteronism (PA). However, AVS protocols are not standardised and vary between centres. The objective of the present study was to assess whether the presence or absence of contralateral adrenal (CL) suppression has an impact on the postope...

ea0035p50 | Adrenal cortex | ECE2014

The pathophysiology of aldosterone-producing adenomas associated with their tumor size: the smaller, the higher expression of CYP11B2

Ono Yoshikiyo , Nakamura Yasuhiro , Maekawa Takashi , Felizola Saulo J A , Morimoto Ryo , Iwakura Yoshitsugu , Kudo Masataka , Seiji Kazumasa , Takase Kei , Gomez-Sanchez Celso E , Ito Sadayoshi , Sasano Hironobu , Satoh Fumitoshi

The pathophysiology of aldosterone-producing adenomas (APA), especially those manifesting clinically overt hyperaldosteronism despite their small size, remains unknown. Therefore, we examined the correlation between tumor size and the status of intratumoral steroidogenic enzymes involved in aldosterone biosynthesis using immunohistochemistry. Forty patients with surgically proven APAs following adrenal venous sampling were retrospectively studied. The tumor area at the maximum...