Searchable abstracts of presentations at key conferences in endocrinology

ea0015p24 | Clinical practice/governance and case reports | SFEBES2008

Hypomagnesaemia related to proton pump inhibition

Agarwal Neera , Rees Aled , Scanlon Maurice

A 43-year-old policeman was referred for investigation of recurrent symptomatic hypomagnesaemia. He initially presented with a one week history of dizziness, headaches, and ‘funny turns,’ on a background history of bronchial asthma, reflux oeosphagitis and hypertension. Initial investigations demonstrated hypocalcaemia, hypomagnesaemia and hypophosphataemia. These disturbances were attributed to his thiazide diuretic which was subsequently discontinued; his symptoms ...

ea0013p208 | AMEND Young Investigator's Award | SFEBES2007

An audit of chromogranin requests at a tertiary neuroendocrine referral centre

Kalhan Atul , Evans Carol , Scanlon Maurice , Rees Aled

Background: Chromogranin A and B (CgA, CgB) are widely used as markers of neuroendocrine tumour (NET) disease. However, the sensitivity of the test is variable and the value of CgB measurement is unclear. We thus sought to review 3 years of CgA and CgB requests made in our hospital.Methods: CgA and CgB were measured at the Hammersmith Hospital. Case notes were reviewed in each of these patients.Results: There were 520 tests perform...

ea0013p50 | Clinical practice/governance and case reports | SFEBES2007

Ectopic peptide production by phaeochromocytomas

Owen Penelope , Coombes David Scott , Gill Ben Hope , Davies Stephen , Scanlon Maurice , Rees Aled

A 67 year old female presented with hypertension, oedema and cough. A CT scan of her abdomen showed an enlarged left adrenal gland. Urinary free cortisols were grossly elevated and low dose dexamethasone suppression testing confirmed Cushing’s Syndrome. 24 hour catecholamines were also elevated consistent with a diagnosis of phaeochromocytoma. ACTH levels were high (690 pg/ml) but pituitary MRI was normal. She was commenced on alpha and beta blockade in preparation for su...

ea0013p155 | Diabetes, metabolism and cardiovascular | SFEBES2007

Sodium valproate monotherapy increases ovarian hyperandrogenism but does not affect arterial compliance in young women with epilepsy

Rice Sam , Agarwal Neera , Bolusani Hemanth , Scanlon Maurice , Pierri Melissa , Smith Phil , Rees Aled

Background: Women with epilepsy may be at risk of developing PCOS, but it is unclear whether this is due to the disease or sodium valproate (VPA) therapy. We sought to determine androgenic status and cardiometabolic risk in women taking VPA monotherapy and compared these with subjects taking lamotrigine and healthy controls.Methods: Patients with epilepsy (age 18–43) with no known vascular risk were divided into 3 groups: VPA monotherapy (n=1...

ea0013p233 | Neuroendocrinology and behaviour (including pituitary) | SFEBES2007

Co-cultures of pituitary lactotrophs and folliculostellate cells stimulates connexin 43 expression: a novel role for the nucleoside adenosine

Lewis Barbara , Francis Karen , Pexa Annette , Deussen Andreas , Scanlon Maurice , Rees Daffyd , Ham Jack

Folliculostellate (FS) cells within the anterior pituitary gland produce cytokines and growth factors which are regulated by molecules produced by neighbouring endocrine cells. There are many factors that could potentially be responsible for this intercellular communication that is mediated via connexins (Cx) and gap-junctions. We thus investigated the effect of co-culturing lactotrophs (MMQ) and FS cells (TtT/GF) on Cx43 expression. Our in vitro model system consists o...

ea0013p165 | Diabetes, metabolism and cardiovascular | SFEBES2007

Bone marrow stem cells differentiating along the adipogenic lineage show marked up regulation of the adenosine A1 receptor transcript

Easter Tammy , Lewis B Mary , Elford Carole , Ludgate Marian , Ham Jack , Evans Bronwen , Scanlon Maurice , Lewis Mark

Bone marrow stem cells (BMSCs) are able to differentiate along multiple lineages including adipogenic and osteogenic lineages. The adenosine A1 receptor (A1R) modulates adipose tissue function causing an inhibition of lipolysis. We therefore studied A1R expression in BMSCs induced to differentiate along the adipogenic lineage.BMSCs were isolated from rat femur (10 wk male Wistar), cultured in control medium (alphaMEM 10% FCS) and then plated into adipocy...