Searchable abstracts of presentations at key conferences in endocrinology

ea0041s20.2 | Hitchhiker's guide to the microsmos of GPCRs | ECE2016

Tethered Agonism: a common activation mechanism of glycoprotein hormone receptors

Schoneberg Torsten

Glycoprotein hormone receptors (GPHRs) have been cloned about 25 years ago and, since then, the glycoprotein hormones TSH, LH/hCG and FSH are considered as the agonists for their respective receptors. Additionally to TSH, the TSH receptor for example, can be activated by mutations and autoantibodies causing hyperthyroidism and GravesÂ’ disease, respectively. The mode, how the receptors integrate the activating actions of glycoprotein hormones, mutations and autoantibodies ...

ea0037ep1329 | Clinical Cases–Thyroid/Other | ECE2015

Functional analysis of four mutants of the V2 receptor

Erdem Beril , Schulz Angela , Saglar Emel , Schoneberg Torsten , Deniz Ferhat , Mergen Hatice

Diabetes insipidus is a disorder characterised by severe liquid-imbalance because of the inability to concentrate urine. Inactivating mutations in either arginine vasopressin receptor type 2 (AVPR2) or aquaporin 2 (AQP2) gene can cause congenital Nephrogenic diabetes insipidus (NDI). AVPR2 is a G protein-coupled receptor (GPCR) and is mainly expressed at the basolateral site of the kidneys collecting duct principal cells. Activation of this receptor by vasopressin is responsib...

ea0020htb3 | Hot topics: Basic | ECE2009

Functional relevance of MC3R and GHSR heterodimerization in hypothalamic weight regulation

Rediger Anne , Tarnow Patrick , Gruters Annette , Schafer Michael , Strotmann Rainer , Schoneberg Torsten , Biebermann Heike

By a systematic approach we investigated the interaction of a selective number of GPCRs that are expressed in the arcuate nucleus and known to play an essential role in hypothalamic weight regulation. Based on the results of a sandwich ELISA and fluorescence resonance energy transfer (FRET) approach we report the interaction of the melanocortin three receptor (MC3R) and the growth hormone secretagogue receptor (GHSR) which are coexpressed on arcuate NPY/AgRP neurons. Fu...

ea0016oc3.1 | Diabetes and obesity | ECE2008

Interaction of hypothalamic G-protein-coupled receptors (GPCRs) involved in weight regulation

Rediger Anne , Tarnow Patrick , Bickenbach Annika , Schafer Michael , Strotmann Rainer , Schoneberg Torsten , Gruters Annette , Biebermann Heike

Food intake is centrally regulated in hypothalamic nuclei. Peripheral hormonal signals activate their corresponding receptors in the arcuate nucleus (arc) and modulate the expression of pro-opiomelanocortin (POMC) and neuropetide Y (NPY)/agouti-related-protein (AgRP). Cleavage products of POMC stimulate melanocortin-4-receptors (MC4R) in the paraventricular nucleus (PVN) to inhibit food intake or stimulate MC3Rs in the arc to activate a feedback loop. Further mor...