Searchable abstracts of presentations at key conferences in endocrinology

ea0014p364 | (1) | ECE2007

Comparison between serum calcitonin (CT) levels following Pentagastrin (Pg) and Calcium (CA) stimulus

Bottici Valeria , Sculli Mariangela , Renzini Giulia , Passannanti Paolo , Lucchetti Fabiana , Grasso Lucia , Pinchera Aldo , Elisei Rossella

Serum CT is the most specific marker of Medullary Thyroid carcinoma (MTC). Although Pg test is the most frequently used to induce CT secretion, the poor availability of Pg makes it necessary to look for different agents. Aim of this work was to compare the induction of CT secretion following 2 different stimuli in the same patient. We studied 25 patients (14 females, 11 males; mean age 50±15 yrs; range 12–77 yrs). All patients were subjected to both tests by injectio...

ea0014oc5.4 | Thyroid basic | ECE2007

BRAFV600E mutations but not RET/PTC rearrangements are correlated with a lower expression of NIS mRNA expression in papillary thyroid cancer (PTC)

Romei Cristina , Piampiani Pamela , Faviana Pinuccia , Basolo Fulvio , Bottici Valeria , Sculli Mariangela , Berti Piero , Materazzi Gabriele , Pinchera Aldo , Elisei Rossella

Several studies have identified a relationship between oncogene activation and dedifferentiation of PTC. Mutations of RAS, RET/PTC and BRAF modulate the expression of thyroid genes. An impaired NIS expression has been demonstrated in PTCs harboring the BRAFV600E mutation.Aim of this study was to analyze BRAF and RET/PTC1-3 alterations and their influence on the expression of thyroid differentiation genes. Seventy-one PTC samples were studied. Quantitative analysis o...

ea0014p362 | (1) | ECE2007

Prognostic value of polymorphisms and somatic RET proto-oncogene mutations in sporadic medullary thyroid carcinoma (MTC)

Cosci Barbara , Romei Cristina , Piampiani Pamela , Sculli Mariangela , Miccoli Paolo , Ugolini Clara , Minuto Michele , Pinchera Aldo , Elisei Rossella

Germline point mutations of the RET proto-oncogene are causative of hereditary MTC. Somatic mutations are described in 40% of sporadic MTCs. Although a relationship between somatic mutations and bad prognosis has been described, data are controversial.No date on the prognostic value of RET polymorphisms are available.Aim of the work was to verify if the presence of a somatic RET mutation and or a polymorphisms can influence the prognosis of MTC. This stu...