Endocrine Abstracts

Introduction: Accumulating evidence indicate that high PTH resulting from primary or secondary hyperparathyroidism, is associated with hypertension, insulin resistance, dyslipidaemia, obesity, and cardiovascular mortality. Here, we aimed to show whether high PTH levels in obese population contribute the metabolic complications of obesity.Methods/design: The medical records of all subjects attending the obesity outpatient clinic of Kartal Dr Lutfi Kirdar ...

Objective: Estrogen or raloxifen prevent estrogen deficiency-induced bone loss animals and humans. There is a medical need for agent with the positive effects of estrogen on bone and the cardiovascular system, but without the negative effects tissue. So, we investigated the effects of raloxifen on bone strength and cholesterol levels in osteoporotic rats and compared them with estrogen treatment.Methods: Thirty-one ovariectomized (OVX) Sprague-Dawney ra...

Objective: HMG Coenzyme A reductase inhibitors (statins) mainly decrease low-density lipoproteins (LDL) cholesterol but also have been found to have beneficial effects in the skeleton. The aim of this study was to examine atorvastatin effects in vivo on femoral and vertebral bone strength.Methods: An ovariectomized (OVX), a glucocorticoid induced osteoporotic (GIO) and an OVX plus GIO group of rat models were used to study the effects of atorvastatin. Sp...