Endocrine Abstracts

Background: Excessive ingestion of Liquorice produces a state of apparent mineralocorticoid excess may result in sodium and water retention, hypertension, hypokalemia and suppression of the renin-aldosterone system. Yorkshire is famous for Liquorice confectionaries. In this paper we discuss about a patient with persistent hypokalemia secondary to excessive liquorice.Case report: Fifty years old lady referred by GP with one year history of hypertension on...

Introduction: It is well-known that prolactinomas sometimes resolve following pregnancy. We wanted to see how often this happens and pregnancy outcome.Patients and methods: From mid 2008 to mid 2013, 66 patients with hyperprolactinemia were studied. 39 had definite microprolactinomas, four probable microprolactinomas, three macroprolactinomas, eight nontumoral hyperprolactinemia and 12 patients were diagnosed elsewhere so no scan results were available. ...

Case history: A 27 years old lady having presented with a neck mass, underwent a total thyroidectomy for thyroid malignancy in 1967. Histology confirmed papillary carcinoma of the thyroid. In 1968, she complained of tiredness and mild neck swelling despite TSH suppressive therapy. Her thyroid uptake study showed a residuum of thyroid tissue within the neck. She went on to have radioiodine ablation therapy on two separate occasions. She responded well with no evidence of residu...

Coeliac disease is more common in people who have Type 1 diabetes mellitus (DM) because of their autoimmune co-existence. Between 4 and 9% of people with Type 1 DM will also have coeliac disease. The updated NICE guideline (NG 20 coeliac screening) recommends that adult with Type 1 DM should be tested for coeliac disease at diagnosis and retested if any symptoms of coeliac disease develop.Study method & Result: Newly...

Coeliac disease is more common in people who have Type 1 diabetes mellitus (DM) because of their autoimmune co-existence. Between 4 and 9% of people with Type 1 DM will also have coeliac disease. The updated NICE guideline (NG 20 coeliac screening) recommends that adult with Type 1 DM should be tested for coeliac disease at diagnosis and retested if any symptoms of coeliac disease develop.Study method & Result: Newly...

Hyperglycaemia is common in patients (~65%) when they are admitted to hospital with ACS. It is recognised to be one of the important prognostic indicators for all-cause mortality in patients who present with ACS, regardless of pre-existing diabetes1. NICE guidelines recommend to keep blood glucose (BG) levels below 11 mmol/l2 and offer all people with hyperglycaemia after ACS (without known diabetes) for HbA1c 3 check before discharge. We were interested to see whether we foll...

Introduction: NICE recommends weight loss surgery as a treatment option for people with obesity. However, long term data on outcomes and complications on surgery are limited. We report unexplained adrenal insufficiency post bariatric surgery.Case report: Patient one27 years old lady underwent Roux-en-Y gastric bypass (RYGB). Weight loss (kg) was from 130.2 to 73.2 over a 2-year period. Patient complained of general unwell and dizzi...

Introduction: Obesity is known to be associated with hypogonadotropic hypogonadism. Hypogonadism is an established risk factor for cardio vascular disease and type 2 diabetes mellitus (T2DM). However there is little evidence on improvement in testosterone with bariatric surgery.Aim and methods: To asses changes in testosterone levels after bariatric surgery. Retrospective study on men undergoing bariatric surgery, and data collected pre and post surgery....

Background: Hypercortisol states present a diagnostic conundrum. Other conditions such as cyclical and subclinical Cushings pose additional challenges. We report a complex clinical presentation of thymoma with coexisting subclinical Cushing’s.Case report: A 65-year-old man presented to chest clinic with breathlessness and anterior mediastinal mass on CXR. CT scan demonstrated a 7.5 cm probable thymoma and bilateral adrenal masses of varying sizes up...

Background: Current conclusions on risk of second brain tumour following radiotherapy for pituitary adenoma or craniopharyngioma are challenged methodologically by small patient sample size, selection biases or lack of appropriate controls.Objective: To ascertain whether radiotherapy for pituitary adenoma or craniopharyngioma is associated with increased second brain tumour risk, through use of appropriate methodology.Design: Multi...