Searchable abstracts of presentations at key conferences in endocrinology

ea0034p319 | Reproduction | SFEBES2014

Fetal glucocorticoid overexposure impacts on germline epigenetic reprogramming in the rat

Rose Catherine M , van den Driesche Sander , Boyle Ashley K , Chambers Thomas , Sharpe Richard M , Meehan Richard R , Drake Amanda J

Background: Fetal glucocorticoid overexposure is associated with low birthweight and increased cardiovascular disease risk in the offspring. Such ‘programmed effects’ can be transmitted across generations through both male and female lines. Disruption of a germline epigenetic reprogramming pathway, characterised by genome-wide erasure and subsequent re-establishment of DNA methylation, may underpin the intergenerational transmission of programmed effects. We used a r...

ea0031p292 | Pituitary | SFEBES2013

Perinatal origins of adult Leydig cells and function: role of developmental androgens

Kilcoyne Karen , Atanossova Nina , Franca Luiz Renato de , Lara Nathalia , Gendt Karel De , Verhoeven Guido , McKinnell Chris , Macpherson Sheila , Driesche Sander van den , Smith Lee , Sharpe Richard M

Fetal events can affect adult testosterone levels but how this occurs is unknown, as adult Leydig cells (ALC) do not differentiate until puberty. Qin et al. 2008 (PLos ONE) identified that chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) is essential postnatally for ALC development. We hypothesized that: i) COUP-TFII+ non-Leydig interstitial cells are progenitors for ALC and are present in the fetal testis, ii) these ‘pr...