ea0029p988 | Growth hormone IGF axis - basic | ICEECE2012
Akamizu T.
, Sakura N.
, Shigematsu Y.
, Tajima G.
, Ohtake A.
, Hosoda H.
, Iwakura H.
, Ariyasu H.
, Kangawa K.
Ghrelin requires a fatty acid modification for binding to the GH secretagogue receptor. Octanoylation of the Ser3 residue of ghrelin is essential for ghrelin-mediated stimulation of GH secretion and regulation of energy homeostasis via increased food intake and adiposity. Other than octanoylation (C8:0), the hormone is subject to other types of acyl modification, decanoylation (C10:0), and possibly decenoylation (C10:1). The fatty acid substrate that contributes to ghrelin acy...