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ea0034p304 | Pituitary | SFEBES2014

Disordered sleep architecture is a common finding in acromegaly

Powlson Andrew S , Bala Laksha , Annamalai Anand K , Koulouri Olympia , Webb Alison , Moir Samantha , Shneerson John M , Gurnell Mark

Sleep disordered breathing (SDB), including obstructive sleep apnoea (OSA), is associated with excessive daytime somnolence, and impacts significantly on quality of life in affected individuals. It also predisposes to premature cardiovascular (hypertension, congestive cardiac failure, myocardial infarction, sudden death, and stroke) and metabolic (diabetes mellitus and dyslipidaemia) dysfunction.SDB is a well-recognised complication of acromegaly. In mos...

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ea0013p247 | Neuroendocrinology and behaviour (including pituitary) | SFEBES2007

Sleep disorders and response to treatment in the ‘Acromegalic cardiovascular and respiratory outcomes with primary analogue therapy (ACROPAT)’ trial

Webb Alison , Pilsworth Sam , O’Toole Sam , Strey Chris , Ariyaratnam Shaumya , George Emad , Majeed Joohi , Melvin Alison , Morrish Nick , Roland Jonathan , Smith Ian , Wood Diana , Chatterjee Krishna , Simpson Helen , Shneerson John , Gurnell Mark

Respiratory disorders are a major cause of illness and impaired physical function in patients with acromegaly, contributing to 25% of all recorded deaths, with respiratory mortality 3-fold higher than in normal subjects. Sleep apnoea (SA), the phenomenon of recurrent cessation or decrease of airflow to the lungs during sleep, is the commonest reported respiratory complication. Both obstructive (OSA) and central (CSA) sleep apnoeas are known to occur, although the overall preva...

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Endocrine Abstracts

Disordered sleep architecture is a common finding in acromegaly

Sleep disorders and response to treatment in the ‘Acromegalic cardiovascular and respiratory outcomes with primary analogue therapy (ACROPAT)’ trial

BiosciAbstracts