Endocrine Abstracts

It is known that adult growth hormone deficiency (GHD) is associated with oxidative stress (OS): both GH and IGF-1 exert antioxidant functions. OS is in turn related to systemic inflammation and cardiovascular/oncological risk. Discordant data concerning GH effects on antioxidants are reported. Moreover, no data are available in partial GHD, which can induce cardiovascular alterations. To evaluate oxidative damage on macromolecules and systemic inflammation, 80 patients, studi...

Hypothyroidism and autoimmune thyroiditis are common in patients with Down’ syndrome (DS), leading to common prescription of thyroid replacement therapy. On the other hand, thyroid function is involved in oxidative stress (OS) mechanisms. DS is a well-known high OS condition because several genes involved in OS mechanisms map on chromosome 21 and coenzyme Q10, lipophilic antioxidant, could be more correlated with hypothyroidism than TSH in DS people. To investigate relati...

Male idiopathic osteoporosis is an underestimated disease, despite its clinical and social importance. The biochemical mechanisms are still poorly understood even if the interaction between genetic factors and hormone environment (especially gonadal steroids and GH) plays a undoubtful role. In previous studies we demonstrated low plasma total antioxidant capacity (TAC) in hypogonadal patients. The aim of this study was to investigate oxidative stress as risk factor for bone fr...

Background: The recently discovered myokin Irisin, a peptide originated by a proteolytic cleavage of the transmembrane protein fibronectin type III domain containing 5 (FNDC5) whose expression is induced by exercise and/or by increasing peroxisome proliferator-activated receptor (PPAR)-γ co-activator 1α (PGC-1α), has been considered a prognostic factor in Chronic Ischemic Cardiomyopathy and Acute Heart Failure. Nevertheless, no data are available on Irisin level...

Adult growth hormone deficiency (GHD), a condition characterized by increased oxidative stress (OS), is related to augmented cardiovascular, metabolic and oncological risk. Thymidine-glycol (ThyG) (5, 6-dihydro-5, 6-dihydroxy-2’-deoxythymidine) is a marker of DNA oxidation produced when thymidine is damaged by hydroxyl radicals. It is considered a specific marker since it is not incorporated in RNA; while 8-OH-deoxyguanosine, a well-known marker of oxidative damage, is ra...

Non-thyroidal-illness syndrome (NTIS) is present in chronic diseases and considered an adaptive mechanism. However oxidative stress is linked to NTIS in a vicious circle, due to deiodinases alteration and negative effects of low T3 on antioxidant levels or activity. Moreover there is a tissue-specific thyroid hormone transport, receptor binding and hormone metabolism. Muscle is one of the main targets of thyroid hormone; on the other hand, Irisin is a novel discovered myokine ...

In heart failure with reduced ejection fraction, catabolic mechanisms have a strong negative impact on mortality and morbidity. The relationship between anabolic hormonal deficiency and heart failure with preserved ejection fraction (HFpEF) has still been poorly investigated. On the other hand, oxidative stress is recognized as a player in the pathogenesis of HFpEF. Therefore, we performed a cohort study in HFpEF in order to: 1) define the multi-hormonal deficiency prevalence ...