Searchable abstracts of presentations at key conferences in endocrinology

ea0070ep3 | Adrenal and Cardiovascular Endocrinology | ECE2020

Advantage and trustworthy of cortisol and dexamethasone evaluation in different biological matrices in patients with adrenal masses

Lionetto Luana , Maggio Roberta , Lardo Pina , De Bernardini Donatella , Cipolla Fabiola , Capi Matilde , Simmaco Maurizio , Pugliese Giuseppe , Stigliano Antonio

Biochemical function of adrenal masses is currently based on 1 mg post-overnight dexamethasone suppression test (pDST). Several approaches are recently developed, in order to reduce false positive/negative samples, only in retrospective series. They are based on the correlation of some different parameters, i.e. late-night salivary cortisol (LNSC) vs serum and salivary cortisol pDST; LNSC vs serum and salivary cortisol and serum dexamethasone pDST; LNSC and cortisone vs serum ...

ea0016p5 | Adrenal | ECE2008

Modulation of proteomic profile in h295r adrenocortical cell line induced by mitotane

Stigliano Antonio , Cerquetti Lidia , Sampaoli Camilla , Misiti Silvia , Borro Marina , Gentile Giovanna , Argese Nicola , Simmaco Maurizio , Toscano Vincenzo

Background: Mitotane, 1,1-dichloro-2-(o chlorophenyl) -2- (p-chloro phenyl) ethane (o,p′-DDD) is a compound which represents the effective agent in the treatment of the adrenocortical carcinoma (ACC), able to block cortisol synthesis. Nevertheless the biological mechanism induced by this treatment in this cancer remains unknown. Recently, there has been a strong interest in applying proteomics to foster a better understanding of disease proces...

ea0070aep1091 | Hot topics (including COVID-19) | ECE2020

Low FT3 serum values are associated with markers of disease severity, evaluated during the acute phase of COVID-19

Sciacchitano Salvatore , Giovagnoli Simonetta , D’Ascanio Michela , De Dominicis Chiara , Laghi Andrea , Anibaldi Paolo , De Vitis Claudia , Petrucca Andrea , Amodeo Rachele , Simmaco Maurizio , Napoli Christian , Mancini Rita , Ricci Alberto

Low T3 syndrome is a frequent finding in patients with critical illness, particularly in those admitted to intensive care units. It is generally considered an adaptive state of thyroid hormone (TH) economy, but many evidences indicate that it may represent a negative prognostic factor too. The prevalence and clinical relevance of the Low T3 syndrome in coronavirus infections has not been evaluated yet. We have measured thyroid hormone levels and analyzed anamnestic, epidemiolo...