Endocrine Abstracts

Biochemical function of adrenal masses is currently based on 1 mg post-overnight dexamethasone suppression test (pDST). Several approaches are recently developed, in order to reduce false positive/negative samples, only in retrospective series. They are based on the correlation of some different parameters, i.e. late-night salivary cortisol (LNSC) vs serum and salivary cortisol pDST; LNSC vs serum and salivary cortisol and serum dexamethasone pDST; LNSC and cortisone vs serum ...

Background: Mitotane, 1,1-dichloro-2-(o chlorophenyl) -2- (p-chloro phenyl) ethane (o,p′-DDD) is a compound which represents the effective agent in the treatment of the adrenocortical carcinoma (ACC), able to block cortisol synthesis. Nevertheless the biological mechanism induced by this treatment in this cancer remains unknown. Recently, there has been a strong interest in applying proteomics to foster a better understanding of disease proces...

Low T3 syndrome is a frequent finding in patients with critical illness, particularly in those admitted to intensive care units. It is generally considered an adaptive state of thyroid hormone (TH) economy, but many evidences indicate that it may represent a negative prognostic factor too. The prevalence and clinical relevance of the Low T3 syndrome in coronavirus infections has not been evaluated yet. We have measured thyroid hormone levels and analyzed anamnestic, epidemiolo...