ea0073aep28 | Adrenal and Cardiovascular Endocrinology | ECE2021
Cerquetti Lidia
, Bucci Barbara
, Raffa Salvatore
, Lardo Pina
, Maggio Roberta
, Simonini Chiara
, Petrangeli Elisa
, Toscano Vincenzo
, Pugliese Giuseppe
, Stigliano Antonio
The lack of an effective medical treatment for adrenocortical carcinoma (ACC) has prompted the, search for better treatment protocols for ACC neoplasms. Sorafenib, a tyrosine kinase inhibitor has exhibited effectiveness in the treatment of different human tumors. Therefore, the aim of this study was to understand the mechanism through which sorafenib acts on ACC, especially since treatment with sorafenib alone is sometimes unable to induce a long-lasting antiproliferative effe...