Searchable abstracts of presentations at key conferences in endocrinology

ea0025p309 | Steroids | SFEBES2011

Utility of basal DHEAS measurement in the detection of subclinical autonomous glucocorticoid hypersecretion in adrenal incidentaloma

Annamalai Anand K , Kandasamy Narayanan , Freeman Natalie , Venugopal Kuhan , Chia Jonathan , Shaw Ashley , Simpson Helen L , Halsall David , Gurnell Mark

Background: Adrenal incidentalomas (AI) are identified in 4–7% of patients >40 years undergoing abdominal CT/MRI. Evidence of subclinical autonomous glucocorticoid hypersecretion (SAGH) is found in 5–10% of cases depending on the diagnostic criteria/thresholds adopted.Aim: To examine the utility of basal DHEAS measurement in the detection of SAGH in a cohort of patients with AI.Methods: Ninety-six consecutive subjects...

ea0021p204 | Endocrine tumours and neoplasia | SFEBES2009

Temozolomide-induced regression of hepatic metastases in a pituitary corticotroph carcinoma with low O6-methylguanine-DNA methyltransferase expression

Burton Hannah , Annamalai Anand K , Dean Andrew , Kovacs Kalman , Antoun Nagui , Kirollos Ramez W , Simpson Helen L , Jeffries Sarah J , Burnet Neil G , Gurnell Mark

Background: Pituitary carcinoma occurs in ~0.2% of resected pituitary tumours, and carries a poor prognosis (mean survival <4 years), with standard chemotherapeutic regimens showing limited efficacy. However, recent evidence suggests that temozolomide, an orally active alkylating agent used principally in the management of glioblastoma, may also be effective in controlling aggressive/invasive pituitary adenomas/carcinomas. Low levels of expression of the DNA-repair enzyme ...

ea0031p164 | Neoplasia, cancer and late effects | SFEBES2013

Diagnosis, localisation and management of insulinoma; a single-centre experience

Powlson Andrew S , Challis Benjamin , Curran Suzanne , Jah Asif , Praseedom Raj , Huguet Emmanuel , Jamieson Neville , Metz Andrew , Carroll Nicholas , Shaw Ashley , Halsall David , Gurnell Mark , Krishna Chatterjee V , Simpson Helen L

Nineteen cases of insulinoma were treated in this centre between 2003 and 2012 (12 female, 7 male, 5 associated with MEN-1). Of the cohort, 14 had their primary investigation and management here. All presented with symptoms consistent with hypoglycaemia and had a supervised fast demonstrating serum glucose <2.2 mmol/l with inappropriately normal/elevated insulin.11 of 14 patients proceeded to surgery. Two elderly patients declined further investigati...