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ea0090oc3.1 | Oral Communications 3: Pituitary and Neuroendocrinology 1 | ECE2023

Diagnosing Vasopressin Deficiency (Central Diabetes Insipidus) using Copeptin following Hypertonic Saline and Arginine Stimulation

Refardt Julie , Atila Cihan , Chifu Irina , Ferrante Emanuele , Erlic Zoran , Drummond Juliana , Mantovani Beatrice , Drexhage Roos , Odilia Sailer Clara , Widmer Andrea , Felder Susan , Powlson Andrew , Hutter Nina , Vogt Deborah , Gurnell Mark , Soares Beatriz Santana , Hofland Hans , Beuschlein Felix , Fassnacht Martin , Winzeler Bettina , Christ-Crain Mirjam

Background: The main challenge in the diagnosis of arginine vasopressin deficiency (AVP-deficiency, formerly known as central diabetes insipidus), is its distinction against primary polydipsia. Hypertonic saline stimulated copeptin showed a high diagnostic accuracy of 97% in distinguishing between AVP-deficiency and primary polydipsia (Fenske W, Refardt J, NEJM 2018), but comprises discomfort for patients and requires close sodium monitoring. Arginine stimulated copeptin showe...

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Diagnosing Vasopressin Deficiency (Central Diabetes Insipidus) using Copeptin following Hypertonic Saline and Arginine Stimulation

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