Oral Communications 3: Pituitary and Neuroendocrinology 1

ea0090oc3.1 | Oral Communications 3: Pituitary and Neuroendocrinology 1 | ECE2023

Diagnosing Vasopressin Deficiency (Central Diabetes Insipidus) using Copeptin following Hypertonic Saline and Arginine Stimulation

Refardt Julie , Atila Cihan , Chifu Irina , Ferrante Emanuele , Erlic Zoran , Drummond Juliana , Mantovani Beatrice , Drexhage Roos , Odilia Sailer Clara , Widmer Andrea , Felder Susan , Powlson Andrew , Hutter Nina , Vogt Deborah , Gurnell Mark , Soares Beatriz Santana , Hofland Hans , Beuschlein Felix , Fassnacht Martin , Winzeler Bettina , Christ-Crain Mirjam

Background: The main challenge in the diagnosis of arginine vasopressin deficiency (AVP-deficiency, formerly known as central diabetes insipidus), is its distinction against primary polydipsia. Hypertonic saline stimulated copeptin showed a high diagnostic accuracy of 97% in distinguishing between AVP-deficiency and primary polydipsia (Fenske W, Refardt J, NEJM 2018), but comprises discomfort for patients and requires close sodium monitoring. Arginine stimulated copeptin showe...

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ea0090oc3.2 | Oral Communications 3: Pituitary and Neuroendocrinology 1 | ECE2023

Protein supplementation increases plasma sodium levels and urinary urea excretion in patients with chronic SIAD – A monocentric open-label proof-of-concept study -The treasure study

Monnerat Sophie , Atila Cihan , Baur Fabienne , Dickenmann Michael , Christ-Crain Mirjam

Introduction: The syndrome of inappropriate antidiuresis (SIAD) is the most common cause of euvolemic hyponatremia. Besides fluid restriction, increasing free water clearance is an effective treatment approach that can be achieved through osmotic diuresis by administering oral urea. Dietary proteins are metabolized into soluble excretable urea by the liver. We hypothesized that dietary protein could increase free water clearance through urea-induced osmotic diuresis and theref...

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ea0090oc3.3 | Oral Communications 3: Pituitary and Neuroendocrinology 1 | ECE2023

[18F]FET PET-MRI; a novel and improved technique for detection of small functional pituitaryadenomas

Pruis Ilanah , Balvers Rutger , Harteveld Anita , Feelders Richard , Vernooij Meike , Smits Marion , Verburg Erik , van Zanten Sophie Veldhuijzen , Neggers Sebastian

Background: Small functional pituitary adenomas can cause severely disabling symptoms and early death, however, surgical planning is often complicated due to inconclusive diagnostic MRI in up to 40% of patients and therefore hamper cure rates. We here introduce a novel method for the detection of small functional pituitary adenoma by O-(2-[18F]-fluoroethyl)-L-tyrosine ([18F]FET) PET-MRI.Methods: Patients with Cushings disease (CD) or acromegaly wit...

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ea0090oc3.4 | Oral Communications 3: Pituitary and Neuroendocrinology 1 | ECE2023

Measurements of growth hormone using dried blood spots in preterm neonates: reference values and longitudinal evaluation.

Giacchetti Federico , Vidali Matteo , Orsenigo Chiara , Vizzari Giulia , Tarricone Silvia , Vantaggiato Chiara , Rodari Giulia , Modugno Adriana Di , Napolitano Filomena , Sangiorgio Andrea , Morniroli Daniela , Colombo Lorenzo , Profka Eriselda , Collini Valentina , Gianni Maria Lorella , Mantovani Giovanna , Mosca Fabio , Ceriotti Ferruccio , Arosio Maura , Giavoli Claudia

Background and Aim: Congenital growth hormone deficiency (cGHD) is a rare but life-threatening condition whose diagnosis is challenging in the absence of reliable reference values, both in healthy neonates and in preterm ones. We recently estimated GH reference interval in 1036 healthy, at-term newborns (HN) form dried blood spot samples using a previously validated analytical method. Aim of this study is to provide values for random GH in preterm newborns (PN).<p class="a...

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ea0090oc3.5 | Oral Communications 3: Pituitary and Neuroendocrinology 1 | ECE2023

Interest of serum and salivary cortisol diurnal cycle in the positive diagnostic of Cushing syndrome and in the differential diagnosis of pseudo-Cushing syndrome

Fideline Bonnet , Poirier Jonathan , El Khoury Ralph , Laguillier-Morizot Christelle , Leguy Marie-Clemence , Thomeret Louis , Bouys Lucas , Guignat Laurence , Assie Guillaume , Groussin Lionel , Guibourdenche Jean , Bertherat Jerome

Introduction: Biological diagnosis of Cushing syndrome relies on three parameters: 24 hours-free urinary cortisol; serum cortisol after 1 mg dexamethasone suppression test; late-night serum or salivary cortisol. These tests allow the diagnosis of cortisol excess but do not help in etiological diagnosis, particularly in the distinction between pseudo-Cushing and ACTH-dependent Cushing syndrome, which is often challenging. The aim of this study was to evaluate the performances o...

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ea0090oc3.6 | Oral Communications 3: Pituitary and Neuroendocrinology 1 | ECE2023

Venous thrombotic events (VTE) across ERCUSYN: details of these VTE’s and do centres anticoagulate on a routine bases?

Isand Kristina , Feelders Richard , Brue Thierry , Toth Miklos , Deutschbein Timo , Reincke Martin , Krsek Michal , Vives Alicia Santos , Demtroder Frank , Chabre Olivier , J. Strasburger Christian , Wass John , Webb Susan M , Maso Ana Aulinas , Volke Vallo , Valassi Elena

For all ERCUSYN investigatorsBackground: Patients with Cushings syndrome (CS) have an increased risk of developing venous thromboembolic complications. There is currently no standard practise for thromboprophylaxis in CS patients.Aim: To study the details of VTE in patients included in The European Registry on Cushings syndrome (ERCUSYN) and study various thromboprophylaxis protocols used among the centres where VTE&#14...

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Endocrine Abstracts

25th European Congress of Endocrinology