Searchable abstracts of presentations at key conferences in endocrinology
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25th European Congress of Endocrinology

Istanbul, Turkey
13 May 2023 - 16 May 2023

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ECE 2023 will be held in Istanbul, Turkey from 13-16 May 2023. Istanbul is known for its rich culture, historical sites and dynamic nightlife, and we are excited to come together in this city, and look forward to meeting old friends, making new ones, and sharing science, collaborations and ideas.

Oral Communications

Oral Communications 4: Reproductive and Developmental Endocrinology

ea0090oc4.1 | Oral Communications 4: Reproductive and Developmental Endocrinology | ECE2023

Gender-affirming hormone treatment: friend or foe? Long term follow-up of 755 transgender and gender diverse people

Spaggiari Giorgia , Marinelli Lorenzo , Cacciani Marta , Scipio Sofia , Bichiri Andreina , Profeta Alessandra , Granata Antonio Raffaele Michele , Ghigo Ezio , Simoni Manuela , Motta Giovanna , Santi Daniele

Background: Gender-affirming hormone treatment (GAHT) is the cornerstone in the therapeutic management of transgender and gender diverse (TGD) people, which are currently classified as transgender assigned-female-at birth (t-AFAB) and assigned-male-at birth (t-AMAB) subjects. Due to its hormonal nature, GAHT is commonly handled by the endocrinologist and available guidelines on this topic mimic the recommendations for cis-gender hypogonadal populations. However, the GAHT long ...

ea0090oc4.2 | Oral Communications 4: Reproductive and Developmental Endocrinology | ECE2023

Inhibition of RANKL in the testis increased the number of motile sperm in a sub-group of infertile men with preserved Sertoli cell function

Hjorth Andreassen Christine , Mortensen Li Juel , Holt Rune , Knudsen Nadia Krarup , Nielsen John Erik , Juul Anders , Jorgensen Anne , Jensen Martin Blomberg

Currently, no treatment options exist to improve semen quality for the majority of infertile men. Proper interaction between germ and Sertoli cells in the testis is critical for sperm production, and a recent study suggested that Denosumab, an inhibitor of RANKL signaling, may stimulate sperm production in some infertile men. Here, we show in animal and human studies how expression of the RANKL signaling system is critical for both Sertoli cell function and the testicular resp...

ea0090oc4.3 | Oral Communications 4: Reproductive and Developmental Endocrinology | ECE2023

The association between selected serum microRNAs, adipokine concentrations, and body composition assessed with dual-energy X-ray absorptiometry in young women with polycystic ovary syndrome

Krentowska Anna , Ponikwicka-Tyszko Donata , Lebkowska Agnieszka , Adamska Agnieszka , Hryniewicka Justyna , Sztachelska Maria , Milewska Gabriela , Wolczynski Slawomir , Kowalska Irina

Introduction: Polycystic ovary syndrome (PCOS) is associated with an increased risk of abdominal obesity, what is regulated by numerous genetic, epigenetic, and environmental factors. MicroRNAs (miRNAs) are known regulators of gene expression, involved in the development of metabolic disturbances. Dual-energy X-ray absorptiometry (DXA) is an accurate method of body composition analysis. The aim of the present study was to investigate the association between circulating miRNAs,...

ea0090oc4.4 | Oral Communications 4: Reproductive and Developmental Endocrinology | ECE2023

A complex crosstalk between estrogen receptor β isoform signaling regulates human granulosa cell growth

Marie Clementine , Corre Raphael , Pierre Alice , Guigon Celine , Cohen-Tannoudji Joelle , Chauvin Stephanie

Estradiol (E2), produced by granulosa cells (GCs) of ovarian follicles, plays an essential role in folliculogenesis by controlling follicular development and selection. E2 actions are principally mediated by the two nuclear receptors, ERα and ERβ. These two receptors are differently expressed in GCs, with ERβ being predominant. After ligand binding and receptor dimerization, ERα and ERβ mainly regulate gene transcription through direct interaction with...

ea0090oc4.5 | Oral Communications 4: Reproductive and Developmental Endocrinology | ECE2023

Reprogramming of reproductive signals via human luteinizing hormone/choriogonadotropin receptor (LHCGR)/G protein-coupled estrogen receptor (GPER) heteromers

Lazzaretti Clara , Paradiso Elia , Sperduti Samantha , Sayers Niamh , Pelagatti Ginevra , D'Alessandro Sara , Perri Carmela , Baschieri Lara , Mascolo Elisa , Roy Neena , Simoni Manuela , Hanyaloglu Aylin , Casarini Livio

In the ovary, the G protein-coupled estrogen receptor (GPER) forms heteromeric complexes with the follicle-stimulating hormone receptor (FSHR), reprogramming FSH-induced signals and determining the follicular fate. Based on the structural similarity, we evaluated whether GPER interacts with the luteinizing hormone (LH)/choriogonadotropin (hCG) receptor (LHCGR) modulating gonadotropin-dependent signals. LHCGR-GPER heteromers were evaluated in transiently transfected HEK293 cell...

ea0090oc4.6 | Oral Communications 4: Reproductive and Developmental Endocrinology | ECE2023

The severity of hot flashes is associated with the risk for incident metabolic syndrome and new-onset hypertension after the menopause

Armeni Elena , Augoulea Areti , Efstathiou Andreas , Chatzivasileiou Panagiota , Kaparos George , Vlahos Nikolaos , Eleftheriades Makarios , Lambrinoudaki Irene

Introduction: A growing body of evidence supports the possible association between the severity of climacteric symptoms and long-term cardiometabolic risk. We aimed to assess the possible link between the severity of hot flashes and the risk for cardiometabolic manifestations after the menopausal transition.Methods: This cohort study was conducted in the Menopause Clinic, National and Kapodistrian University of Athens, Aretaieio Hospital, Athens, Greece....