Searchable abstracts of presentations at key conferences in endocrinology

ea0063eyijc1 | (1) | ECE2019

The metabolic effects of SGLT2 inhibitors – Does the increase in ketone bodies protect the heart?

Sondergaard Esben

Type 2 diabetes causes excess cardiovascular mortality and microvascular disease. Therefore, the results of the EMPA-REG OUTCOME trial were received with great excitement, since this was the first trial with cardiovascular end points to show a benefit for persons suffering from type 2 diabetes. The striking benefit of a 38% reduction in cardiovascular mortality during SGLT2 inhibitor treatment was surprising and exceeded what was expected based on the relatively modest reducti...

ea0090p412 | Pituitary and Neuroendocrinology | ECE2023

Copeptin levels increase in response to both insulin-induced hypoglycemia and arginine but not to clonidine – data from GH-stimulation tests

Stankovic Jelena , Kristensen Kurt , Birkebaek Niels , Otto Jorgensen Jens , Sondergaard Esben

Background: The differential diagnosis of the polyuria-polydipsia syndrome is challenging. The water-deprivation test is the current gold standard, but the test is cumbersome, and the diagnostic performance is poor. Copeptin, which is a split product of the vasopressin pre-propeptide, appears to be a robust biomarker in the circulation and a promising tool for the diagnosis of patients with polyuria and polydipsia, especially when measured in conjunction with intravenous infus...

ea0049oc1.4 | Adrenal-Basic & Clinical | ECE2017

The epidemiology of pheochromocytoma: increasing incidence and changing clinical presentation. A population-based retrospective study 1977–2015

Ebbehoj Andreas Ladefoged , Sondergaard Esben , Trolle Christian , Stochholm Kirstine , Poulsen Per Logstrup

Pheochromocytoma is a rare disease but frequently poses a diagnostic dilemma due to the unspecific symptoms and its potentially life-threatening nature. There is a perception of an increase in the incidence of pheocromocytomas in recent years, but no data on time trends exist. We obtained data from The Danish National Registry of Patients, The Danish Registry of Causes of Death, and The National Pathology Registry for all persons registered with pheochromocytoma in 1977–2...

ea0032p213 | Clinical case reports – Pituitary/Adrenal | ECE2013

Case report: chronic adrenergic stimulation induces brown adipose tissue differentiation in visceral adipose tissue

Sondergaard Esben , Gormsen Lars C , Pedersen Steen B , Christiansen Peer , Nielsen Soren , Poulsen Per L , Jessen Niels

Introduction: The presence of brown adipose tissue (BAT) in humans has recently been demonstrated by histology and positron emission tomography (PET). In previous reports, BAT in adults is primarily confined to the upper chest and neck. Here, we report a case of massive BAT infiltration of the visceral adipose tissue in a patient with catecholamine secreting paraganglioma.Methods: The patient was evaluated with [18F]-FDG PET/CT at three occasi...

ea0056gp44 | Adrenal medulla and NETs | ECE2018

Mortality in patients with Pheochromocytoma: a population-based study 1977–2016

Ebbehoj Andreas Ladefoged , Sondergaard Esben , Jacobsen Sarah Forslund , Trolle Christian , Robaczyk Maciej Grzegorz , Rasmussen AEse Krogh , Feldt-Rasmussen Ulla , Thomsen Reimar Wernich , Stochholm Kirstine , Poulsen Per Logstrup

Background: Pheochromocytomas and catecholamine-secreting paragangliomas (PPGL) are rare catecholamine-producing tumors. Due to the rarity, limited data on prognosis exists and data are mainly from tertiary centers with potential referral bias. Here, we present population-based mortality data over an observation period of 40 years.Materials and methods: We identified a cohort of 198 PPGL patients diagnosed 1 January 1977 to 31 December 2016 in North and ...