Searchable abstracts of presentations at key conferences in endocrinology
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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

Oral Communications

Adrenal-Basic & Clinical

ea0049oc1.1 | Adrenal-Basic & Clinical | ECE2017

High resolution tissue mass spectrometry imaging: a new tool for identification of prognostic markers in adrenocortical carcinoma

Kunzke Thomas , Sun Na , Sbiera Silviu , Wild Vanessa , Aichler Michaela , Ronchi Cristina , Schlegel Nicolas , Rosenwald Andreas , Fassnacht Martin , Walch Axel , Kroiss Matthias

Adrenocortical carcinoma (ACC) is an orphan tumor entity the pathogenesis of which is poorly understood. In advanced tumour stages, prognosis is unfavorable, but biomarkers for early diagnosis are lacking. MALDI-Mass Spectrometry Imaging (MALDI-MSI) enables semi-quantitative detection of a broad spectrum of analytes including endogenous cell metabolites in tissue sections. MALDI-MSI was used as a discovery approach to analyse tissue specimens of 72 ACC patients in FFPE tissue ...

ea0049oc1.2 | Adrenal-Basic & Clinical | ECE2017

EZH2: a master regulator of adrenal cortex homeostasis and zonation

Mathieu Mickael , Drelon Coralie , Tabbal Houda , Rodriguez Stephanie , Septier Amandine , Berthon Annabel , Sainte-Catherine David , Breault David , Martinez Antoine

In adult mice the adrenal cortex is divided, in two distinct functional zones, outermost zona glomerulosa (ZG) and innermost zona fasciculata (ZF), encapsulated by a thin layer of mesenchymal cells (capsule). The adrenal cortex undergoes constant centripetal cell renewal, reliying on recruitment of progenitors located within an outer cortex niche. Progenitors initially differentiate as ZG cells and undergo lineage conversion to ZF as they move within the cortex. This relies on...

ea0049oc1.3 | Adrenal-Basic & Clinical | ECE2017

Steroid metabolomics for accurate and rapid diagnosis of inborn steroidogenic disorders

Baranowski Elizabeth , Bunte Kerstin , Shackleton Cedric H L , Taylor Angela E , Hughes Beverley A , Biehl Michael , Tino Peter , Guran Tulay , Arlt Wiebke

Background: Urinary steroid metabolite profiling is an accurate reflection of adrenal and gonadal steroid output and metabolism in peripheral target cells of steroid action. Measurement of steroid metabolite excretion by gas chromatography-–mass spectrometry (GC–MS) is considered reference standard for biochemical diagnosis of steroidogenic disorders. However, performance of GC–MS analysis and interpretation of the resulting data requires significant expertise a...

ea0049oc1.4 | Adrenal-Basic & Clinical | ECE2017

The epidemiology of pheochromocytoma: increasing incidence and changing clinical presentation. A population-based retrospective study 1977–2015

Ebbehoj Andreas Ladefoged , Sondergaard Esben , Trolle Christian , Stochholm Kirstine , Poulsen Per Logstrup

Pheochromocytoma is a rare disease but frequently poses a diagnostic dilemma due to the unspecific symptoms and its potentially life-threatening nature. There is a perception of an increase in the incidence of pheocromocytomas in recent years, but no data on time trends exist. We obtained data from The Danish National Registry of Patients, The Danish Registry of Causes of Death, and The National Pathology Registry for all persons registered with pheochromocytoma in 1977–2...

ea0049oc1.5 | Adrenal-Basic & Clinical | ECE2017

Diagnostic accuracy of three confirmatory tests for primary aldosteronism: a prospective study and systematic review

Li Qifu , Song Ying , Yang Shumin , Zhang Aipin

Background: Confirmatory tests, including saline infusion test (SIT), captopril challenge test (CCT) and fludrocortisone suppression test (FST) are commonly used for diagnosis of primary aldosteronism (PA). Each test has its advantages and disadvantages, but which one should be preferentially performed is controversial. We aimed to evaluate the diagnostic accuracy of three tests in a prospective study.Methods: Five hundred and thirty-one hypertensive pat...