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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

Oral Communications

Diabetes Prediction and Complications

ea0049oc2.1 | Diabetes Prediction and Complications | ECE2017

microRNA expression profile in plasma from patients with type 1 diabetes: a case–control study and bioinformatics analysis

Assmann Tais Silveira , Recamonde-Mendoza Mariana , Punales Marcia , Tschiedel Balduino , Canani Luis Henrique , Crispim Daisy

Context: Since the exact cause of type 1 diabetes mellitus (T1DM) remains unclear, the detection of novel biomarkers is necessary to complement the information obtained from the presence of autoantibodies together with genetic and environmental risk factors. MicroRNAs (miRNAs) are a class of small noncoding RNA molecules that negatively regulate gene expression. Changes in their expression were described in several pathological conditions, including autoimmune diseases. Circul...

ea0049oc2.2 | Diabetes Prediction and Complications | ECE2017

Effectiveness of complex therapy in patients with comorbidity of type 2 diabetes and essential hypertension depending on genetic polymorphism PPARγ2

Shalimova Anna , Bilovol Oleksandr , Bobronnikova Lesya

The aim: To evaluate effectiveness of complex therapy in patients with comorbidity of type 2 diabetes (DM2) and essential hypertension (EH) depending on genetic polymorphism peroxisome proliferator-activating receptor-γ2 (PPARγ2). Before and after 3 months of treatment we examined 145 patients with EH stage II, grade and DM2 moderate, subcompensated aged 45–60 years: group 1 (71 patients) received standart therapy (telmisartan, indapamide, metformin, gliclazide,...

ea0049oc2.3 | Diabetes Prediction and Complications | ECE2017

GLP-1 based multi-agonists-induced signaling includes profound TRP channel involvement in insulin secretion

Khajavi Noushafarin , Finan Brian , Kluth Oliver , Mergler Stefan , Muller Timo , Kleinau Gunnar , Schurmann Annette , Tschop Matthias H , DiMarchi Richard , Krude Heiko , Biebermann Heike

Promiscuous multi-agonists that simultaneously activate two or three key receptors (incretin- and/or glucagon receptor) were recently shown to improve glycemic control in mice. Here we investigated the underlying mechanisms of multi-agonists to enhance insulin secretion in murine islets and human pancreatic β-cells. These mixed agonists display a greater potency in cAMP signaling as compared to the native incretins. However, pharmacological blockade of cAMP signaling only...

ea0049oc2.4 | Diabetes Prediction and Complications | ECE2017

Effect of alive probiotic on insulin resistance in type 2 diabetes patients: randomized clinical trial

Kobyliak Nazarii , Kondratiuk Kateryna , Kyriienko Dmytro , Mykhalchyshyn Galyna

Background: Probiotics have beneficial effect on obesity related disorders in animal models. Despite a large number of animal data, randomized placebo-controlled trials (RCT) concluded that probiotics have a moderate effect on glycemic control-related parameters. However, effect of probiotics on insulin resistance are inconsistent.Aim: In a double-blind single center RCT, effect of alive multistrain probiotic vs placebo on insulin resistance in type 2 di...

ea0049oc2.5 | Diabetes Prediction and Complications | ECE2017

Urinary peptidomics for the detection of diabetic kidney disease

Brondani Leticia A , Soares Ariana A , D'Allagnol Angelica , Camargo Joiza L , Monteiro Karina , Silveiro Sandra P

Background: Diabetic kidney disease (DKD) is the main cause of end-stage renal disease It is defined by glomerular filtration rate (GFR) impairment and/or presence of increased urinary albumin excretion (UAE). However, these parameters are nonspecific and somewhat delayed manifestations of renal damage. Thus, earlier DKD new biomarkers are strongly warranted.Objective: To investigate the urinary peptidomics profile of type 2 diabetes mellitus (DM) patien...