Searchable abstracts of presentations at key conferences in endocrinology

ea0091p41 | Poster Presentations | SFEEU2023

Cushing’s Disease in the time of COVID

Tyndall Victoria , Ritchie Stuart

Case history: A 37 year old mother of two was referred to DGH by the GP for possible PCOS in 2019. She had an 18 months of weight gain, hirsuitism, oligomenorrhoea, abdominal distension, back pain and fatigue. Medical history included asthma and she worked as a teacher. On Endocrine clinic review, she was noted to be floridly Cushingoid. Urgent referral to tertiary Endocrinology in Edinburgh was auctioned and a diagnosis of Cushing’s Disease was made alongside multiple re...

ea0059ep44 | Clinical practice, governance & case reports | SFEBES2018

Iatrogenic Cushings secondary to inhibition of triamcinolone metabolism by cobicistat

Foteinopoulou Evgenia , Ritchie Stuart

Background: CYP3A4 is the most prevalent cytochrome P450 (CYP) enzyme in the liver, and is used by the majority of medications for their metabolism and elimination from the body. The inhibition of CYP3A4 can result in the accumulation of drug concentrations increasing the risk for possible toxicity. We report a case of iatrogenic Cushings’s syndrome secondary to impaired CYP3A4 metabolism of triamcinolone by coadministration of darunavir/cobicistat, with resultant seconda...

ea0013p159 | Diabetes, metabolism and cardiovascular | SFEBES2007

The interactions between insulin and tumour necrosis factor-alpha in human aortic endothelial cells

Ritchie Stuart , Connell John , Salt Ian

There is a significant body of research that demonstrates an association between central (visceral) obesity, insulin resistance, endothelial dysfunction and accelerated atherosclerosis, but the molecular mechanisms underlying this link are incompletely understood. In cultured human aortic endothelial cell (HAEC) models, insulin stimulates an intracellular signalling cascade resulting in activating phosphorylation of Insulin Receptor Substrate-1, Protein kinase B (PKB/Akt) and ...

ea0052p40 | (1) | UKINETS2017

Pancreatic VIPoma – a diagnostic and symptom control challenge

Jack Ross , Fineron Paul , Patel Dilip , Ritchie Stuart , Subedi Deepak , Wall Lucy

A case is reported of a man with stage IV grade 2 pancreatic VIPoma. At diagnosis he had several features which may have expedited the diagnosis including refractory diarrhoea containing undigested foodstuffs, alcohol-related flushing, electrolyte abnormalities and intestinal oedema on imaging. Symptom control was challenging. There was no benefit from creon, loperamide or codeine and escalation to both short and long acting somatostatin analogues was futile. Consistent with a...