ea0022h2.5 | Oral Communications Highlights 2 | ECE2010
Boelen Anita
, Van Beeren Mieke
, Vos Xander
, Surovtseva Olga
, Kwakkel Joan
, Fliers Eric
Fasting induces profound metabolic changes in order to decrease energy expenditure and to conserve energy. One of the major adaptations is downregulation of the hypothalamus–pituitary–thyroid (HPT) axis, characterized by decreased serum thyroid hormone levels without an increase in serum TSH or in TRH expression in the hypothalamic paraventricular nucleus (PVN). Leptin has been proposed as a critical signal initiating the neuroendocrine response to fasting as it decr...