Searchable abstracts of presentations at key conferences in endocrinology

ea0011p334 | Diabetes, metabolism and cardiovascular | ECE2006

Regulation of hexose-6-phosphate dehydrogenase (H6PDH) in human fetal liver WRL-68 cells

Swali A , Bujalska I , Stewart PM , Walker EA

Excessive glucocorticoid exposure has been implicated in the pathogenesis of obesity and the metabolic syndrome. The in vivo conversion of inactive to active glucocorticoids is catalysed by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), requiring NADPH as a cofactor. Hexose-6-phosphate dehydrogenase (H6PDH) is co-localised with 11β-HSD1 in the lumen of the endoplasmic reticulum and controls local NADPH availability. Thus H6PDH plays an important role...

ea0008p54 | Growth and development | SFE2004

Early development and subsequent metabolic parameters in Holstein-Friesian Dairy Cows

Swali A , Taylor VJ , Beever DE , Wathes DC

Dairy cows normally calve for the first time when not yet fully grown. Subsequent pregnancies occur during lactation. Therefore in primiparous (PP) cows the fetus competes for nutrients with maternal growth, while in multiparous (MP) cows they compete with milk production. Human epidemiological studies demonstrate that low birth weight can predispose offspring to a variety of metabolic diseases in adult life. This study investigated the hypothesis that such competition limits ...

ea0015p327 | Steroids | SFEBES2008

A paracrine role for 11β-hydroxysteroid dehydrogenase type 1 and glucocorticoids in the murine pancreatic islet

Swali Angelina , Tomlinson Jeremy , Walker Elizabeth , Stewart Paul

Type 2 diabetes manifests when pancreatic β-cells secrete inadequate insulin in response to elevated glucose. A known culprit in metabolic diseases is excessive exposure to glucocorticoids (GCs). GCs increase hepatic gluconeogenesis, decrease insulin sensitivity in skeletal muscle and adipose tissue and suppress the development of β-cells. In rodents, inactive GC 11-dehydrocorticosterone (A) is converted to active corticosterone (B) by the enzyme 11β-hydroxyster...

ea0013p160 | Diabetes, metabolism and cardiovascular | SFEBES2007

Immunohistochemical localisation of 11β-hydroxysteroid dehydrogenase type 1 in murine pancreatic islets

Swali Angie , Walker Elizabeth , Tomlinson Jeremy , Stewart Paul

The metabolic syndrome, which encompasses features of obesity, insulin resistance, dyslipidaemia and hypertension, has been associated with excessive glucocorticoid (GC) exposure. The pancreas is a target of the adverse affects of GC action, resulting in β-cell damage and reduced glucose-stimulated insulin secretion (GSIS). 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyses the in vivo conversion of inactive to active glucocorticoids (cortisone E/11-de...