Searchable abstracts of presentations at key conferences in endocrinology

ea0032oc4.6 | Adrenal | ECE2013

9-cis retinoic acid, a novel treatment option for adrenocortical cancer? in vitro and in vivo studies

Szabo Diana Rita , Baghy Kornelia , Szabo Peter M , Falus Andras , Kovalszky Ilona , Patocs Attila , Racz Karoly , Igaz Peter

Background: The medical treatment options of adrenocortical cancer are limited. In our previous meta-analysis of adrenocortical tumor genomics data, adrenocortical cancer was found to be associated with reduced retinoic acid production and retinoid X receptor-mediated signaling.Objective: To study the potential antitumoral effects of 9-cis-retinoic acid (9-cisRA) on the adrenocortical cancer cell line NCI-H295R and in a xenograft model....

ea0035oc10.1 | Endocrine Tumours | ECE2014

Blood-borne and tissue microRNAs in adrenocortical tumours: affected pathways and diagnostic relevance

Igaz Peter , Szabo Diana Rita , Zsippai Adrienn , Szabo Peter M , Nagy Zoltan , Toth Miklos , Luconi Michaela , Mannelli Massimo , Patocs Attila , Racz Karoly

Background: The differential expression of tissue microRNAs in benign and malignant adrenocortical tumours has been described in several studies including ours. Novel data show that microRNAs are also present in the bloodstream and can be exploited as minimally invasive markers of malignancy.Objective: To analyze the microRNAs expressed in different studies by an in silico approach and to establish the molecular pathways affected. Furthermore, circulatin...