Searchable abstracts of presentations at key conferences in endocrinology
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15th European Congress of Endocrinology

ea0032oc4.1 | Adrenal | ECE2013

Pre-clinical model detects castrate-resistant cancer repopulating cells in localised prostate tumours

Risbridger Gail , Toivanen Roxanne , Frydenberg Mark , Murphy Declan , Pedersen John , Ryan Andrew , Pook David , Berman David , Taylor Renea

Introduction: Lack of clinically relevant experimental models of human prostate cancer hampers evaluation of novel therapeutic agents. Currently, androgen deprivation therapy is the gold standard treatment for advanced prostate cancer, but inevitably cells survive and repopulate the tumour. Castrate-resistant cells are critical therapeutic targets for more effective treatments but current model systems cannot determine when they arise in disease progression and are unable to r...

ea0032oc4.2 | Adrenal | ECE2013

Single nucleotide polymorphism array profiling of adrenocortical tumors: evidence for an adenoma carcinoma sequence?

Ronchi Cristina , Sbiera Silviu , Leich Ellen , Rosenwald Andreas , Allolio Bruno , Fassnacht Martin

Background: Adrenocortical tumors consist of benign adenomas (ACA) and highly malignant carcinomas (ACC) with a still incompletely understood pathogenesis. Our aim was to test, whether there is evidence for an adenoma-carcinoma sequence.Patients and methods: High-resolution single nucleotide polymorphism (SNP) microarrays (Affymetrix SNP 6.0) were used to detect copy number alterations (CNAs) and copy neutral losses of heterozygosity (cnLOH) in 46 adreno...

ea0032oc4.3 | Adrenal | ECE2013

Prognostic factors of advanced unresectable by stage III and IV ENS@T adrenocortical carcinomas (ACC)

Libe Rossella , Borget Isabelle , Ronchi Cristina , Terzolo Massimo , Haaf Michaela , Laino Federica , Kherkhof Thomas , Corsini Elisa , Tabarin Antoine , Chabre Olivier , De la Fouchardiere Christelle , Niccoli Patricia , Caron Philippe , Mannelli Massimo , Haak Harm , Beuchlein Felix , Bertherat Jerome , Berruti Alfredo , Fassnacht Martin , Baudin Eric

Introduction: The prognosis of stages III–IV ACC patients is dismal. The 5-year survival of stage IV ACC ranges between 0 and 13% and no prognostic study has focused on stage III, yet. Several reports suggest a greater heterogeneity of advanced ACC prognosis that initially thought.Aim: The primary objective of our study was to analyse the prognostic factors of overall survival of the subgroup of advanced unresectable stage III–IV ACC patients c...

ea0032oc4.4 | Adrenal | ECE2013

Neuronal dysfunction in the hippocampi of cured Cushing's syndrome patients, detected by 1H-MR-spectroscopy

Resmini Eugenia , Santos Alicia , Gomez-Anson Beatriz , Lopez-Mourelo Olga , Pires Patricia , Vives-Gilabert Yolanda , Crespo Iris , Portella Maria , de Juan-Delago Manel , Webb Susan

Introduction: Proton magnetic resonance spectroscopy (1H-MRS) is a sensitive, non-invasive imaging technique capable of measuring brain metabolites in vivo. Chronic exposure to endogenous hypercortisolism in Cushing’s syndrome (CS) is associated with negative effects on memory and hippocampal volumes, even after biochemical cure.Objective: To investigate metabolites in the hippocampi of CS patients and controls, using 1</sup...

ea0032oc4.5 | Adrenal | ECE2013

ESE Young Investigator Award

Oszwald Andrea , Fischer Evelyn , Bidlingmaier Martin , Pallauf Anna , Degenhart Christoph , Beuschlein Felix , Reincke Martin

Adrenal vein sampling (AVS) is a technically demanding procedure required for identification of suitable candidates for unilateral adrenalectomy in primary aldosteronism. Recently, somatic mutations in aldosterone producing adenomas (APA) have become a focus of research. We identified KCNJ5 K+-channel mutations in 34% of APAs, and more recently mutations in 2 ATPase family members in 11 and 6%. However, it is unclear whether steroid gradients during the AVS are infl...

ea0032oc4.6 | Adrenal | ECE2013

9-cis retinoic acid, a novel treatment option for adrenocortical cancer? in vitro and in vivo studies

Szabo Diana Rita , Baghy Kornelia , Szabo Peter M , Falus Andras , Kovalszky Ilona , Patocs Attila , Racz Karoly , Igaz Peter

Background: The medical treatment options of adrenocortical cancer are limited. In our previous meta-analysis of adrenocortical tumor genomics data, adrenocortical cancer was found to be associated with reduced retinoic acid production and retinoid X receptor-mediated signaling.Objective: To study the potential antitumoral effects of 9-cis-retinoic acid (9-cisRA) on the adrenocortical cancer cell line NCI-H295R and in a xenograft model....