Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 32 | ECE2013 | Next issue

15th European Congress of Endocrinology

Oral Communications

Reproduction

ea0032oc5.1 | Reproduction | ECE2013

BMP15-dependent gene-expression profiling in human granulosa cells

Rossetti Raffaella , Gentilini Davide , Beccaria Elena , Paffoni Alessio , Persani Luca

The oocyte-derived growth and differentiation paracrine factor BMP15 has emerged as an essential regulator of the ovarian folliculogenesis, from evidences in animal models (knockout mice and sheeps with naturally occurring mutations) and humans. Indeed, several BMP15 mutations have been identified in association with primary ovarian insufficiency (POI), a heterogeneous and frequent fertility disorder characterized by the premature depletion of ovarian follicles in women <4...

ea0032oc5.2 | Reproduction | ECE2013

The (TAAAA)n polymorphism in the SHBG gene is related to prenatal androgenization of female fetus: possible implications of the developmental origin of metabolic disorders

Pamporaki Christina , Xita Nectaria , Lazaros Leandros , Makridimas George , Georgiou Ioannis , kolios George , Plachouras Nikolaos , Tsatsoulis Agathocles

Introduction: The aim of this study was to examine whether the distribution of SHBG (TAAAA)n repeat variants contributes to the exposure of the female fetus to androgen excess, by influencing the, in utero, androgen availability.Methods: The study population consisted of 100 pregnant women that carried female fetuses and underwent the procedure of amniocentesis due to age (older than 35). Blood samples and amniotic fluid samples were dr...

ea0032oc5.3 | Reproduction | ECE2013

Age-related hormonal and metabolic alterations in women with polycystic ovary syndrome (PCOS)

Pinola Pekka , Vanky Eszter , Sundstrom-Poromaa Inger , Stener-Victorin Elisabeth , Puurunen Johanna , Piltonen Terhi , Puukka Katri , Tapanainen Juha , Morin-Papunen Laure

Introduction: PCOS-related hormonal and metabolic alterations seem to persist later in life. The aim was to investigate age-related hormonal and metabolic parameters in PCOS and in healthy women in order to determine cut-off values predicting PCOS.Subjects and methods: PCOS women and 230 healthy controls were divided accordingly: 18–24, 25–29, 30–34, 35–39, 40–44, 45–49 and >50 years. A particular interest was to analyze...

ea0032oc5.4 | Reproduction | ECE2013

Influence of variants in the FSHB and FSHR gene on reproductive parameters in males and females

Gromoll Joerg , Schuring Andreas , Busch Alexander , Kliesch Sabine , Tuttelmann Frank

Background: Recently, a single nucleotide polymorphism (SNP) in the FSHB promoter (−211G>T, rs10835638) was found to be associated with lower serum FSH levels and oligozoospermia in males. In contrast, a SNP in the FSH-receptor gene (FSHR, 2039A>G, rs6166) was previously shown to be associated with FSH levels in women only.Subjects and methods: One thousand two hundred and thirteen male partners in infertile couples without known c...

ea0032oc5.5 | Reproduction | ECE2013

FSHB −211 and FSHR 2039 polymorphisms are associated with serum levels of FSH, AMH and age of pubertal onset in 78 healthy girls: a longitudinal cohort study

Hagen Casper P , Aksglaede Lise , Sorensen Kaspar , Mouritsen Annette , Mieritz Mikkel G , Main Katharina M , Almstrup Kristian , Rajpert-De Meyts Ewa , Anderson Richard A , Juul Anders

Context: Potency of the FSH-pathway varies according to polymorphisms in the promoter of the gene encoding the FSH beta subunit (FSHB −211 G>T, rs10835638) and in the gene encoding the FSH receptor (FSHR 2039 A>G, rs6166). A recent study suggested that carriers of the combination of FSHB GG and FSHR AA had the most reproductive ‘fit’ phenotype (higher serum FSH and a more sensitive FSH receptor). In pre-pubertal girls...

ea0032oc5.6 | Reproduction | ECE2013

INSL3 in 268 male patients with congenital hypogonadotropic hypogonadism (CHH): effects of different modalities of hormonal treatment

Trabado Severine , Maione Luigi , Sarfati Julie , Salenave Sylvie , Chanson Philippe , Brailly-Tabard Sylvie , Young Jacques

Context: Insulin-like peptide three (INSL3) is a testicular hormone, secreted by Leydig cells, during fetal life, in newborns, and after puberty. These 3 phases of testicular activation are impaired in CHH.Objective: To evaluate in a single center circulating INSL3 in a significant series of men with CHH in order to asses the consequences of pre- and postnatal gonadotropin deficiency, to specify the INSL3 regulation by gonadotropins and to evaluate the p...