Endocrine Abstracts

Introduction: Type 2 diabetes is one of the most common health problems worldwide and its prevalence is rapidly increasing. Although environmental factors play a substantial role in the etiology, genetic susceptibility has been established as an important risk factor. Several recent genome-wide studies and linkage analysis testing have identified and confirmed various T2D susceptibility loci. However, as demonstrated by the results of the HapMap project and by other s...

Obesity is usually considered to be a forerunner to insulin resistance (IR). Using in vitro studies, we have identified a role for the giant protein AHNAK in regulating Glut4 expression and function. Ex vivo analysis of white adipose tissue from ob/ob mice and aged/obese rats exhibited elevated AHNAK protein levels (2.3- and 3- fold) with concomitant reduction in Glut4 levels (5- and 2-fold).The aim of this study was to investigate the ...

Glucagon-like peptide-1 (GLP-1) is an incretine hormone with multiple actions besides control of glucose homeostasis. GLP-1 is known to cause natriuresis in humans but the effects on basic renal physiology are still partly unknown.This study therefore aimed to demonstrate the effects of GLP-1 on kidney hemodynamics, electrolyte handling, and the renin–angiotensin–aldosterone system in healthy men.Twelve healthy young male...

Objectives: Sirolimus inhibits adipocyte differentiation (Yeh PNAS 1995). This study compares weight and fat markers in two groups of patients treated or not with sirolimus, before and after transplantation.Patients and method: Nineteen islet-alone transplanted patients treated with sirolimus and 7 islet-alone or liver-transplanted patients NOT treated with sirolimus were compared 1 year after transplantation in terms of weight, fat mass (equation of bod...

Introduction: Macrophages and lymphocytes are considered as major players in adipose tissue (AT) inflammation and liver steatosis, contributing to metabolic dysregulation during obesity. The costimulatory molecules B7.1 and B7.2 are important regulators of T-cell activation and inflammatory reactions, however, their contribution in obesity-related AT and liver low-grade inflammation is poorly characterized.Methods: Mice sufficient or deficient in B7.1 an...

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