Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep810 | Reproductive and Developmental Endocrinology | ECE2020

Prenatal programming of hepatic lipid metabolism: Sex, hormones and lifelong health

Siemienowicz Katarzyna , Filis Panagiotis , Talia Chiara , Thomas Jennifer , Fowler Paul , Duncan Colin , Rae Mick

Background: The potential for a healthy life is programmed by in utero development. Fetal development is impacted by perturbed hormonal signalling, with lifelong consequences. Polycystic Ovary Syndrome (PCOS), affecting over 10% of women, is an important condition linked to an altered prenatal endocrine environment. Women with PCOS have increased androgen concentrations, including during pregnancy. Increased prenatal androgen exposure is associated with a PCOS-phenoty...

ea0059p169 | Obesity & metabolism | SFEBES2018

Angiopoietin-like ptotein 4 and 8 (ANGPTL4 and ANGPTL8) in human fetal liver are dysregulated by in utero exposure to maternal smoking

Talia Chiara , Filis Panagiotis , Soffientini Ugo , Lucendo-Villarin Baltasar , Douglas Alex , Hay David , Shaw Sophie , Iredale John , Swortwood Madeleine , Huestis Marilyn , Bellingham Michelle , Connolly Lisa , O'Shaughnessy Peter , Fowler Paul

Introduction: Angiopoietin-like proteins (ANGPTLs) are a family of 8 glycoproteins with pleiotropic effects in metabolism, angiogenesis, inflammation and cancer. ANGPTL3, 4 and 8 play major roles in regulating lipid levels, via inhibition of lipoprotein lipase. Increased serum ANGPTL3, 4, 8 levels are associated with obesity, diabetes, metabolic syndrome and fatty liver. Furthermore, cord blood ANGPTL8 is higher than in maternal serum, suggesting a role in fetal development an...