Searchable abstracts of presentations at key conferences in endocrinology

ea0084ps2-08-67 | Thyroid Cancer BASIC | ETA2022

Down-regulated HSA-MIR-204-3p may identify high-risk papillary thyroid carcinoma patients

Stojanović Stefana , Selemetjev Sonja , Đorić Ilona , Jankovic Jelena , Živaljević Vladan , Tatić Svetilsav , Išić Denčić Tijana

Objectives: Finding novel tumor markers capable to recognize aggressive papillary thyroid carcinoma (PTC) forms are of great importance. We evaluated hsa-microRNA-204-3p (miR-204-3p) for differential diagnosis of thyroid tumors and assessed its prognostic usefulness.Methods: MiR-204-3p levels were determined in 77 PTC cases of diverse histological variants, 12 cases of follicular thyroid adenoma (FTA), and 89 matched nonmalignant thyroid epithelial tissu...

ea0092ps1-09-08 | Thyroid Cancer | ETA2023

Overexpression of activated focal adhesion kinase correlates with adverse clinicopathological factors of papillary thyroid carcinoma

Ignjatović Jocić Valentina , Janković Miljuš Jelena , Roncevic Jelena , Tatić Svetilsav , Išić Denčić Tijana , Đorić Ilona , Selemetjev Sonja

Objective: Focal adhesion kinase (FAK) is non-receptor tyrosine kinase that has been shown to affect cell motility, adhesion, invasion, cell survival, proliferation and de-differentiation. Its increased expression has been reported for various types of malignancies and is associated with cancer progression. However, there are less information regarding its posttranslational form, phosphorylated at Tyrosine 397 (pY397-FAK), which represents a key event for complete protein acti...

ea0092ps3-28-07 | Translational 2 | ETA2023

Expression of focal adhesion kinase microrna regulators is related to dedifferentiation in thyroid neoplasia spectrum

Ignjatović Jocić Valentina , Janković Miljuš Jelena , Išić Denčić Tijana , Živaljević Vladan , Tatić Svetilsav , Đorić Ilona , Selemetjev Sonja

Objectives: The specter of malignant thyroid lesions comprises tumors with different degrees of differentiation, rendering the differential diagnosis and prognosis of these tumors challenging. Focal adhesion kinase (FAK) is a tyrosine kinase involved in cellular communication and locomotion, functioning as a hub in the interactome of focal adhesions. Its upregulation has been demonstrated in a number of tumor types including thyroid cancer. FAK is regulated on several levels, ...