Searchable abstracts of presentations at key conferences in endocrinology

ea0056gp119 | Endocrine Case Reports | ECE2018

Non-syndromic multiple insulinomas with atypical clinico-biological presentation in two adult patients: a specific entity?

Bonnet-Serrano Fideline , Lethielleux Gaelle , Gaujoux Sebastien , North Marie-Odile , Terris Benoit , Guibourdenche Jean , Bertherat Jerome

Introduction: Insulinoma is the most frequent functional endocrine tumor of the pancreas but remains rare with an incidence of less than 5 cases by million and by year. It is often sporadic but can occur in the context of MEN1 in about 5% of cases, being then readily multiple. Clinically, it is typically responsible for fasting hypoglycemic episodes. Only one case of multiple insulinomas, with no obvious argument for MEN1 context, has previously been reported (Babic an al., <e...

ea0093p1 | Guided Poster Tour 1: Adrenal and Neuroendocrine tumors | EYES2023

Proposition of an histopathological classification of bilateral macronodular adrenal disease (BMAD) and its correlation with ARMC5 and KDM1A mutations

Violon Florian , Bouys Lucas , Berthon Annabel , Bruno Ragazzon , Barrat Maxime , Terris Benoit , Bertherat Jerome , Sibony Mathilde

Introduction: Bilateral macronodular adrenal disease (BMAD, former PBMAH) is a rare cause of CushingÂ’s syndrome. The few morphologic descriptions of BMAD mention multinodular hyperplastic adrenal glands composed of clear spongiocytic cells and fewer compact eosinophilic cells without any morphologic variation. The discovery of ARMC5 and KDM1A mutations argues for genetic heterogeneity. The aim of this work was to describe the morphological and immunohist...

ea0081p270 | Adrenal and Cardiovascular Endocrinology | ECE2022

Proposition of the first histopathological classification of primary bilateral macronodular adrenal hyperplasia (pbmah) and its correlation with armc5 and kdm1a status

Violon Florian , Bouys Lucas , Vaczlavik Anna , Gaetan Giannone , Berthon Annabel , Ragazzon Bruno , Terris Benoit , Sibony Mathilde , Bertherat Jerome

Introduction: Primary Bilateral Macronodular Adrenal Hyperplasia (PBMAH) is a rare cause of ACTH-independent Cushing syndrome. It is characterized by the development of supracentimetric nodules resulting in increased adrenal volume and weight. Its presentation is clinically, radiologically and biologically heterogeneous. Morphological descriptions of PBMAH are rare. Although the initial description highlights that multinodular hyperplastic adrenal glands are made of a majority...