Searchable abstracts of presentations at key conferences in endocrinology

ea0093oc11 | Oral communication 2: Neuroendocrinology | EYES2023

Soluble alpha klotho, a new biomarker of growth hormone action

Schweizer Junia Ribeiro de Oliveira Longo , Schilbach Katharina , Gagliardo Anica Pauline , Haenelt Michael , Peters Annette , Thorand Barbara , Bidlingmaier Martin

Background: Soluble alpha klotho (sαKL) is high in active acromegaly, normalizes after disease control, and therefore is suggested as a new biomarker for growth hormone (GH) excess. However, little is known about the impact of biological variables other than GH.Methods: Serum sαKL (pg/ml) was measured by ELISA (IBL, Hamburg, Germany). We first evaluated pre-analytical stability, defined a reference interval for sαKL in healthy subjects (A:...

ea0090p419 | Pituitary and Neuroendocrinology | ECE2023

Reference intervals for soluble alpha klotho and the impact of biological variables

Ribeiro de Oliveira Longo Schweizer Junia , Schilbach Katharina , Haenelt Michael , Pauline Gagliardo Anica , Peters Anette , Thorand Barbara , Stormann Sylvere , Schopohl Jochen , Bidlingmaier Martin

Background: Alpha klotho is a transmembrane protein that regulates calcium metabolism. Its soluble portion has been linked to endocrine functions. We have recently shown high concentrations of serum soluble alpha klotho (sαKL) in active acromegaly. There is limited information about regulation of sαKL secretion. We aimed to gain insight about sαKL as a potential biomarker for H-related diseases.Methods: SαKL was measured by ELISA (IBL...