Searchable abstracts of presentations at key conferences in endocrinology
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ESE Young Endocrinologists and Scientists (EYES) 2023

ESE Young Endocrinologists and Scientists (EYES) 2023

Oral communication 2: Neuroendocrinology

ea0093oc9 | Oral communication 2: Neuroendocrinology | EYES2023

Effect of protein supplementation on plasma sodium levels in the syndrome of inappropriate antidiuresis – a monocentric open-label proof-of-concept study – the treasure study

Monnerat Sophie , Atila Cihan , Baur Fabienne , de Jesus Joyce Santos , Refardt Julie , Dickenmann Michael , Christ-Crain Mirjam

Background: The syndrome of inappropriate antidiuresis (SIAD) can be treated with oral urea. Proteins are metabolized into urea by the liver. We hypothesized that dietary protein could increase free water clearance through urea-induced osmotic diuresis.ObjectivesTo investigate the effect of protein supplementation on plasma sodium levels in chronic SIAD.Methods: This is a monocentric open-label proof-of-concept trial conducted at the University Hospital ...

ea0093oc10 | Oral communication 2: Neuroendocrinology | EYES2023

Effects of glucagon-like peptide-1 receptor agonists on copeptin in healthy volunteers and patients with primary polydipsia

Leibnitz Svenja , Christ-Crain Mirjam , Winzeler Bettina

Background: Today, GLP-1 receptor agonists have great clinical importance in the treatment of type 2 diabetes and obesity. Furthermore, GLP-1 seems to play a significant role in sodium and water homeostasis. Recent findings investigating long-term effects of treatment with GLP-1 receptor agonists showed a reduction of fluid intake irrespective of food consumption. To our knowledge, data regarding physiological mechanisms that could explain these observations are inconclusive. ...

ea0093oc11 | Oral communication 2: Neuroendocrinology | EYES2023

Soluble alpha klotho, a new biomarker of growth hormone action

Schweizer Junia Ribeiro de Oliveira Longo , Schilbach Katharina , Gagliardo Anica Pauline , Haenelt Michael , Peters Annette , Thorand Barbara , Bidlingmaier Martin

Background: Soluble alpha klotho (sαKL) is high in active acromegaly, normalizes after disease control, and therefore is suggested as a new biomarker for growth hormone (GH) excess. However, little is known about the impact of biological variables other than GH.Methods: Serum sαKL (pg/ml) was measured by ELISA (IBL, Hamburg, Germany). We first evaluated pre-analytical stability, defined a reference interval for sαKL in healthy subjects (A:...

ea0093oc12 | Oral communication 2: Neuroendocrinology | EYES2023

Psychopathological characteristics in patients with arginine vasopressin deficiency (central diabetes insipidus) and primary polydipsia

Beck Julia , Atila Cihan , Refardt Julie , Erlic Zoran , Drummond Juliana , Rocha Beatriz Santana Soares , Beuschlein Felix , Winzeler Bettina , Christ-Crain Mirjam

The differential diagnosis between arginine vasopressin deficiency (AVP-D), known as central diabetes insipidus, and primary polydipsia (PP) is challenging. Psychopathologic findings are often used as a hallmark for diagnosing PP; thus. Yet, psychopathologic characteristics are barely assessed in patients with AVP-D, and to date, no data exist comparing AVP-D and PP with regard to these features. Therefore, in this study, we aimed to compare levels of anxiety, depression, alex...

ea0093oc13 | Oral communication 2: Neuroendocrinology | EYES2023

Hypogonadotropic hypogonadism in a patient with Allgrove syndrome: A case report

Gheorghe-Milea Ana , Rusu Eva , Stănoiu-Pinzariu Oana , Georgescu Carmen Emanuela

Background: Triple A (Allgrove) syndrome is a rare genetic disorder with autosomal recessive inheritance, caused by mutations in the AAAS gene on chromosome 12q13. It is characterized by the following triad: ACTH-resistant adrenal insufficiency, alacrimia, and achalasia.Case presentation: We present the case of a 19-year-old male who was diagnosed with adrenal insufficiency at the age of five following an addisonian crisis with hypoglycemic coma. At the ...

ea0093oc14 | Oral communication 2: Neuroendocrinology | EYES2023

Comparison of metyrapone, osilodrostat and ketoconazole in the short-term therapy of endogenous Cushing’s syndrome: Preliminary results of the Mosketeer study

Detomas Mario , Simeoli Chiara , Di Paola Nicola , Mazzarella Alessandro , Pivonello Rosario , Ceccato Filippo , Voltan Giacomo , Scaroni Carla , Aulinas Anna , Santos Alicia , Webb Susan , Rubinstein German , Braun Leah , Reincke Martin , Dolce Pasquale , Antonini Simone , Lania Andrea , Stelmachowska-Banaś Maria , Cylke-Falkowska Karolina , Minnetti Marianna , Isidori Andrea M. , Corsello Andrea , Gilis-Januszewska Aleksandra , Minasyjan Mari , Sambula Lana , Kastelan Darko , Deutschbein Timo , Haberbosch Linus , Dischinger Ulrich , Fassnacht Martin , Altieri Barbara

Background: Steroid synthesis inhibitors, like metyrapone, osilodrostat, and ketoconazole are used as second-line treatment in all types of endogenous Cushing’s syndrome (CS). However, a direct comparison of these three drugs is missing. This study aimed to compare these drugs in the short-term therapy of CS.Design: Retrospective multicenter study involving 16 centers worldwide.Methods: Patients with CS treated with metyrapone...