Searchable abstracts of presentations at key conferences in endocrinology
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ESE Young Endocrinologists and Scientists (EYES) 2023

ESE Young Endocrinologists and Scientists (EYES) 2023

Oral communication 1: Adrenal Diseases

ea0093oc1 | Oral communication 1: Adrenal Diseases | EYES2023

Generation and characterization of CYP21A2-I173N MICE: A humanized mutant animal model for 21-hydroxylase deficiency

Thirumalasetty Shamini Ramkumar , Schubert Tina , Naumann Ronald , Reichardt Ilka , Rohm Marie-Luise , Landgraf Dana , Peitzsch Mirko , Sarov Mihail , Reisch Nicole , Huebner Angela , Koehler Katrin

Background: Congenital Adrenal Hyperplasia (CAH) is a group of inherited disorders affecting adrenal steroidogenesis. The main form, 21-hydroxylase deficiency (21-OHD), results from mutations in the CYP21A2 gene. Patients experience hormone deficiencies, and excessive androgens which lead to various symptoms such as hypoglycemia, salt wasting, virilization, and early puberty. Therapy demands high glucocorticoid doses, causing significant side-effects. While new treatm...

ea0093oc2 | Oral communication 1: Adrenal Diseases | EYES2023

Morbidity in patients with chronic adrenal insufficiency – cardiovascular risk factors and hospitalization rate compared to population based controls

Chifu Irina , Quinkler Marcus , Altieri Barbara , Hannemann Anke , Volzke Henry , Lang Katharina , Reisch Nicole , Pamporaki Christina , Willenberg Holger S. , Beuschlein Felix , Burger-Stritt Stephanie , Hahner Stefanie

Objective: Patients with adrenal insufficiency (AI) have been found to have increased cardiovascular morbidity, partly associated with nonphysiologic glucocorticoid replacement.Design: We included two separate cohorts (cohort 1 and 2) of patients with chronic primary and secondary AI under standard replacement therapy and compared them to two age- and sex-matched population-based studies (SHIP-TREND/DEGS). Patient cohort 1 comprised 389 individuals asses...

ea0093oc3 | Oral communication 1: Adrenal Diseases | EYES2023

Preoperative 1 mg dexamethasone suppression test predicts hypothalamus–pituitary–adrenal axis recovery: A one-year retrospective study of adrenal incidentalomas undergoing unilateral adrenalectomy

Bonaventura Ilaria , Tomaselli Alessandra , Angelini Francesco , Ferrari Davide , De Alcubierre Dario , Sada Valentina , Minnetti Marianna , Hasenmajer Valeria , Cozzolino Alessia , Sbardella Emilia , Isidori Andrea , Pofi Riccardo

Background: The evaluation of postoperative adrenal insufficiency (PAI) and hypothalamus–pituitary–adrenal (HPA) axis recovery in patients with adrenal incidentaloma (AI) undergoing unilateral adrenalectomy remains limited.Objectives: We aimed to identify predictive factors for PAI development and evaluate HPA axis recovery in AI patients undergoing unilateral adrenalectomy.Methods: We retrospectively analysed adrenal fun...

ea0093oc4 | Oral communication 1: Adrenal Diseases | EYES2023

Constitutional duplication of PRKACA gene is a cause of isolated primary pigmented nodular adrenocortical disease (PPNAD): Results of its systematic search in bilateral nodular adrenal disease

Vaduva Patricia , Violon Florian , Raverot Gerald , Espiard Stephanie , Attia Amina , Bouys Lucas , Perlemoine Karine , Chasavang Albin , Hieronimus Sylvie , Vantyghem Marie Christine , Polak Michel , Bruno Ragazzon , Jouinot Anne , Pasmant Eric , Bertherat Jerome

Background: Constitutional duplications of the PRKACA gene locus have been described as responsible for adrenal Cushing’s disease.The objective here was to evaluate the results of its systematic screening in bilateral adrenal nodular disease and to specify the associated phenotype.Methods: Between 2020 and 2023, 440 consecutive index cases with macronodular or micronodular adrenal hyperplasia or Carney Complex (CNC) w...

ea0093oc5 | Oral communication 1: Adrenal Diseases | EYES2023

Enhanced inflammation and steroidogenesis sensitize adrenal cells to ferroptosis

Wlodarczyk Agnes , Lehnert Uta , Bornstein Stefan , Kanczkowski Waldemar

Background: Sepsis is a life-threatening inflammatory condition and a leading cause of death in hospitals. It arises when a microbial infection triggers prolonged and uncontrolled systemic inflammation resulting in progressing organ dysfunction. Recent experimental data suggest a possible involvement of ferroptosis – an iron-dependent form of regulated necrosis – in sepsis-mediated damage of many vital organs. However, its role in adrenal gland dysfunction and/or dam...

ea0093oc6 | Oral communication 1: Adrenal Diseases | EYES2023

Outcome of surgical versus conservative management in patients with mild autonomous cortisol secretion

Iftimie Madalina Elena , Burcea Iulia , Dobre Ramona , Baciu Ionela , Niculescu Dan Alexandru , Căpăţană Cristina , Găloiu Simona , Şerban Radian , Baculescu Nicoleta , Trifănescu Raluca , Poiana Catalina

Background: Adrenal incidentalomas (AI) with mild autonomous cortisol secretion (MACS) are associated with increased morbidity and mortality and constitute a common clinical scenario.Objective: We assessed the outcome of cardiovascular risk factors associated with MACS after adrenalectomy versus conservative management.Methods: Retrospective study performed on a cohort of patients evaluated in our clinic between 2018 and 2022 with ...

ea0093oc7 | Oral communication 1: Adrenal Diseases | EYES2023

Clinical prediction model for primary aldosteronism subtyping and special focus on adrenal volumetric assessment: A pilot study

Barlas Tugba , llgit Erhan , Akkan Koray , Cindil Emetullah , Gultekin Isil , Sodan Hulya , Yalcin Muhittin , Cerit Turgay , Sozen Sinan , Akturk Mujde , Toruner Fusun , Karakoc Ayhan , Altinova Alev Eroglu

Background: Adrenal venous sampling (AVS) is the gold standard diagnostic approach for differentiating unilateral from bilateral primary aldosteronism (PA). However, it is a costly, invasive, and operator-dependent procedure with restricted availability.Objectives: It was aimed to develop a prediction model based on a simple clinical score with prominent parameters from the current literature for the subtype diagnosis of PA. The contribution of adrenal v...

ea0093oc8 | Oral communication 1: Adrenal Diseases | EYES2023

FKBP5 methylation in adrenal insufficiency: Looking at a new tool for assessing the quality of glucocorticoid replacement?

Chifu Irina , Richter Anna Lena , Scheuermann Carolin , Burger-Stritt Stephanie , Lippert Juliane , Herterich Sabine , Hahner Stefanie

Introduction: Glucocorticoid (GC) replacement regimens in adrenal insufficiency (AI) only roughly correspond to physiological steroid profiles. Moreover, control of substitution quality is difficult and signs of clinically relevant mild chronic over- or under-replacement might be omitted. FKBP5 regulates GC receptor sensitivity by reducing its affinity to cortisol when bound to the receptor complex. FKBP5 methylation has been inversely correlated with cortisol levels both in h...