ea0038p243 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015
Todorčević Marijana
, Austen Luke
, Manuel Ari
, Michailidou Zoi
, Stradling John
, Karpe Fredrik
Adipose tissue (AT) dysfunction is thought to be a central component in the pathophysiology of obesity-associated metabolic disease. Low AT oxygenation (hypoxia) is suggested to be a driver of this dysfunction, yet studies in humans have resulted in conflicting data. Therefore, we aimed to investigate if markers of AT hypoxia were present in the subcutaneous AT of morbidly obese individuals who had hypoxia from obesity hypoventilation syndrome (OHS), with or without obstructiv...