Searchable abstracts of presentations at key conferences in endocrinology

ea0052nets11 | Speaker Abstracts | UKINETS2017

Debate: There is a role in resection of NET hepatic metastases - surgical dilemma

Armstrong Tom

Tom Armstrong will present evidence to support the role of surgical resection NET liver in the case based discussion detailed above....

ea0044s9.1 | Exposing the sins of our fathers (and mothers) | SFEBES2016

Maternal nutrition around conception and its influence on fetal development and adult health

Fleming Tom

The early embryo before implantation, in addition to undergoing the intrinsic steps of morphogenesis, demonstrates external ’awareness’ of environmental conditions in particular maternal nutritional quality. These nutritional cues are used to optimise the developmental programme for long-term survival, a form of developmental plasticity. Thus, maternal protein restriction exclusively during mouse preimplantation development with normal nutrition thereafter and postna...

ea0028s12.3 | Medullary thyroid cancer | SFEBES2012

The diagnosis and surgical management of medullary thyroid cancer

Kurzawinski Tom

Medullary thyroid cancer (MTC) accounts for 5–10% of all thyroid cancers and can be either sporadic (75%) or familial (25%). Familial MTC is associated with hereditary syndromes such as Multiple Endocrine Neoplasia (MEN) type 2A or 2B and Familial Medullary Thyroid Cancer (FMTC). Sporadic MTC most often present as thyroid nodule and fine needle aspiration cytology combined with elevated plasma calcitonin levels is diagnostic in about 90% of cases. Hereditary forms of MTC ...

ea0021sb1.5 | How to access funds and revolutionise your research | SFEBES2009

Systems biology: a funder's perspective

Foulkes Tom

The MRC currently operates a ‘highlight notice’ in systems biology for medicine. Highlight notices are requests for applications through the normal response mode route – they represent a priority but do not have a specific budget attached. This notice is of considerable relevance to endocrinology research, as will be discussed at the March meeting. MRC-funded endocrinology researchers are already beginning to use systems approaches with some success, but there i...

ea0094ns1.1 | Primary Hyperparathyroidism: diagnosis to treatment | SFEBES2023

Primary Hyperparathyroidism: Can innovative technologies improve current diagnostic and therapeutic pathways?

Kurzawinski Tom

Primary Hyperparathyroidism (PHPT) is, after diabetes and thyroid diseases, the third commonest endocrine disorder and its incidence and prevalence is rising globally. In the United Kingdom, the incidence of PHPT has been estimated to be 25/100,000, and prevalence has risen from 1.8 to 6.7 per 1000 between 1997-2006, implying that in the UK alone, about half a million people suffer from this condition and 12.000 develop it each year. Recognition of increased PHPT related morbi...

ea0094ret2.3 | Section | SFEBES2023

Surgical Precision for RET-related tumour syndromes in the era of Precision Medicine

Kurzawinski Tom

Genetic testing for RET gene was available in the United Kingdom within few years of its discovery, undoubtedly another bonus of universal, nationwide health care system. It was the beginning of Precision Medicine era, which became a watchword for preventative and personalized treatments based on phenotypic, biomarker and genetic characteristics. Surgical Precision on the other hand is an idiom for doing something very well and with meticulous attention to detail. In my presen...

ea0073mte6 | Meet The Expert 6: Difficult phaeochromocytoma cases | ECE2021

Difficult Phaeochromocytoma cases

Zelinka Tomáš

Phaeochromocytoma and paraganglioma (PPGL) are rare neuroendocrine tumours arising from chromaffine cells either from adrenal medulla (phaeochromocytoma) or extra-adrenal paraganglia (paraganglioma). Phaeochromocytomas and sympathetic paragangliomas (arising from thoracic, abdominal, or pelvic sympathetic ganglia) may secrete catecholamines which are associated with the most clinical symptoms and signs whereas parasympathetic paragangliomas (arising from parasympathetic gangli...

ea0027p36 | (1) | BSPED2011

Recurrent hypoglycaemia with hyponatraemia during illness: what lies beneath?

Eames Tom , Puthi Vijith R

Hypoglycaemia is a one of the commonest presentation of an ill child. Hyponatraemia during illness is mostly presumed to be related to syndrome of inappropriate anti diuretic hormone secretion (SIADH). We would like to present an interesting case of hypoglycaemia and hyponatraemia.A four-year-old boy presented with a two-day history of intermittent fever, vacant episodes, and seizures. He was noted to be hypoglycaemic with laboratory glucose of 1.2 mmol/...

ea0090ep399 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Localisation of the steroid 5β-reductase in hepatoma cells

Potter Tom , Tomlinson Jeremy , Gathercole Laura

The hepatic enzyme 5β-reductase (AKR1D1) sits at the interface between two metabolic pathways, converting steroid hormones to their inactive 5β-reduced metabolites during steroid clearance, and as a step in the synthesis of bile acids from cholesterol. Both the steroid substrates and the bile acid products of AKR1D1 are potent hormones that regulate hepatic energy metabolism and inflammation. It is not known how these two functions are spatially organised within hepa...

ea0038p454 | Thyroid | SFEBES2015

Incidental thyroid malignancy in Grave’s thyrotoxicosis

Rashid Nazia , Kurzawinski Tom , Chung Teng-Teng

Introduction: Correlation of papillary thyroid cancer and lymphocytic thyroiditis is well documented but the incidence of thyroid malignancies in Graves’ disease especially in the absence of nodular thyroid disease is considered to be uncommon.Method: We conducted a retrospective audit of forty-four patients with established diagnosis of Grave’s thyrotoxicosis treated with total thyroidectomy from 2010-2013 (36 months), in a tertiary care centr...