Searchable abstracts of presentations at key conferences in endocrinology

ea0052nets11 | Speaker Abstracts | UKINETS2017

Debate: There is a role in resection of NET hepatic metastases - surgical dilemma

Armstrong Tom

Tom Armstrong will present evidence to support the role of surgical resection NET liver in the case based discussion detailed above....

ea0044s9.1 | Exposing the sins of our fathers (and mothers) | SFEBES2016

Maternal nutrition around conception and its influence on fetal development and adult health

Fleming Tom

The early embryo before implantation, in addition to undergoing the intrinsic steps of morphogenesis, demonstrates external ’awareness’ of environmental conditions in particular maternal nutritional quality. These nutritional cues are used to optimise the developmental programme for long-term survival, a form of developmental plasticity. Thus, maternal protein restriction exclusively during mouse preimplantation development with normal nutrition thereafter and postna...

ea0028s12.3 | Medullary thyroid cancer | SFEBES2012

The diagnosis and surgical management of medullary thyroid cancer

Kurzawinski Tom

Medullary thyroid cancer (MTC) accounts for 5–10% of all thyroid cancers and can be either sporadic (75%) or familial (25%). Familial MTC is associated with hereditary syndromes such as Multiple Endocrine Neoplasia (MEN) type 2A or 2B and Familial Medullary Thyroid Cancer (FMTC). Sporadic MTC most often present as thyroid nodule and fine needle aspiration cytology combined with elevated plasma calcitonin levels is diagnostic in about 90% of cases. Hereditary forms of MTC ...

ea0021sb1.5 | How to access funds and revolutionise your research | SFEBES2009

Systems biology: a funder's perspective

Foulkes Tom

The MRC currently operates a ‘highlight notice’ in systems biology for medicine. Highlight notices are requests for applications through the normal response mode route – they represent a priority but do not have a specific budget attached. This notice is of considerable relevance to endocrinology research, as will be discussed at the March meeting. MRC-funded endocrinology researchers are already beginning to use systems approaches with some success, but there i...

ea0073mte6 | Meet The Expert 6: Difficult phaeochromocytoma cases | ECE2021

Difficult Phaeochromocytoma cases

Zelinka Tomáš

Phaeochromocytoma and paraganglioma (PPGL) are rare neuroendocrine tumours arising from chromaffine cells either from adrenal medulla (phaeochromocytoma) or extra-adrenal paraganglia (paraganglioma). Phaeochromocytomas and sympathetic paragangliomas (arising from thoracic, abdominal, or pelvic sympathetic ganglia) may secrete catecholamines which are associated with the most clinical symptoms and signs whereas parasympathetic paragangliomas (arising from parasympathetic gangli...

ea0027p36 | (1) | BSPED2011

Recurrent hypoglycaemia with hyponatraemia during illness: what lies beneath?

Eames Tom , Puthi Vijith R

Hypoglycaemia is a one of the commonest presentation of an ill child. Hyponatraemia during illness is mostly presumed to be related to syndrome of inappropriate anti diuretic hormone secretion (SIADH). We would like to present an interesting case of hypoglycaemia and hyponatraemia.A four-year-old boy presented with a two-day history of intermittent fever, vacant episodes, and seizures. He was noted to be hypoglycaemic with laboratory glucose of 1.2 mmol/...

ea0038p454 | Thyroid | SFEBES2015

Incidental thyroid malignancy in Grave’s thyrotoxicosis

Rashid Nazia , Kurzawinski Tom , Chung Teng-Teng

Introduction: Correlation of papillary thyroid cancer and lymphocytic thyroiditis is well documented but the incidence of thyroid malignancies in Graves’ disease especially in the absence of nodular thyroid disease is considered to be uncommon.Method: We conducted a retrospective audit of forty-four patients with established diagnosis of Grave’s thyrotoxicosis treated with total thyroidectomy from 2010-2013 (36 months), in a tertiary care centr...

ea0037ep318 | Calcium and Vitamin D metabolism | ECE2015

Raised calcium & PTH, not always a primary hyperparathyroidism

Tabassum Fareeda , Baldeweg Stephanie , Kurzawinski Tom

Case: A 50-years-old gentleman underwent cardiac surgery which was complicated by postoperative arrythmias and ischemic stroke. He was found to have raised calcium of 2.9 (2.2–2.6 mmol/l) subsequent to which PTH was tested and found to be raised at 34.2 (1.6–6.9 pmol/l) which increased to 41.2 pmol/l in few days. He was referred for work up and management of primary hyperparathyroidism. An USS of the neck showed 1.5 cm nodule posterior to left thyroid lobe and Sestim...

ea0032p269 | Clinical case reports – Pituitary/Adrenal | ECE2013

Fountain of steroid deep within: a case report of an ectopic ACTH-producing tumor

Lo Tom Edward , Antonio Imelda , Jimeno Cecilia

Background: Cushing’s syndrome is defined as a hormonal disorder resulting from elevated serum cortisol leading to specific physical and biochemical abnormalities that might be detrimental to life itself. Majority is caused by steroid intake while endogenous sources although representing only a minority of patients often lead to delay in diagnosis. Ectopic ACTH syndrome considered a rare entity are usually found as small cell lung cancer and carcinoid tumors. Rare types o...

ea0032p542 | Endocrine tumours and neoplasia | ECE2013

Endogenous Cushing’s syndrome: the Filipino clinical experience of 19 cases

Edward Lo Tom , Cabradilla Joyce , Jimeno Cecilia

Background and significance: Endogenous Cushing’s syndrome is a rare disease entity approximately 13 cases per million population. In Asia, and specifically in the Philippines incidence is unknown. As well, it’s clinical presentation among Filipinos is not well described. The local epidemiology of obesity, diabetes and hypertension are different from other countries. These conditions are the usual initial differential diagnosis for Cushing’s syndrome. This repor...