Endocrine Abstracts

Type 1 diabetes (T1D) is a complex autoimmune disease. Several genetic loci have been implicated in the susceptibility to this illness. Evaluated was the role of the CTLA4 exon 1 A49G polymorphism and its role as a risk factor for T1D in our population. DNA from 120 patients with T1D and 96 control individuals were genotyped for CTLA4 exon 1 polymorphism by polymerase chain reaction (PCR) amplification-restriction enzyme analysis and PCR amplification that used sequence-specif...

Background: The IL-10 promoter polymorphisms −1082G/A, −819C/T, and −592C/A have been consistently associated with type 2 diabetes (T2DM). We examined whether these polymorphisms variants are also associated with progression of diabetic nephropathy (DN).Methods: These promoter variants were genotyped in 917 T2DM patients comprising 515 DN patients and 402 control patients without nephropathy (DWN), together with 748 non-diabetic control...

Aims: Few studies investigated the association of genetic difference in metalloproteinase-2 (MMP-2) gene with diabetic retinopathy but with mixed outcome. The aim of the study is to investigate the association between a set of MMP-2 genetic variants and the risk of diabetic retinopathy in an Arab Tunisian population with type 2 diabetes.Subjects and Methods: A retrospective case-control study involving 779 type 2 diabetes patients with or without diabeti...