Searchable abstracts of presentations at key conferences in endocrinology

ea0020p514 | Endocrine Disruptors | ECE2009

Association of CTLA4+49 A/G polymorphism with type 1 diabetes in Tunisian population

Jihen Benmansour , Mouna Stayoussef , Wassim Almawi , Touhami Mahjoub

Type 1 diabetes (T1D) is a complex autoimmune disease. Several genetic loci have been implicated in the susceptibility to this illness. Evaluated was the role of the CTLA4 exon 1 A49G polymorphism and its role as a risk factor for T1D in our population. DNA from 120 patients with T1D and 96 control individuals were genotyped for CTLA4 exon 1 polymorphism by polymerase chain reaction (PCR) amplification-restriction enzyme analysis and PCR amplification that used sequence-specif...

ea0020p178 | Endocrine tumours and neoplasia | ECE2009

Predictive value of interleukin-10 promoter genotypes and haplotypes in determining the susceptibility to nephropathy in type 2 diabetes patients

Mtiraoui Nabil , Ezzidi Intissar , Chieb Molka , Kacem Maha , Mahjoub Touhami , Almawi WassimY

Background: The IL-10 promoter polymorphisms −1082G/A, −819C/T, and −592C/A have been consistently associated with type 2 diabetes (T2DM). We examined whether these polymorphisms variants are also associated with progression of diabetic nephropathy (DN).Methods: These promoter variants were genotyped in 917 T2DM patients comprising 515 DN patients and 402 control patients without nephropathy (DWN), together with 748 non-diabetic control...