Searchable abstracts of presentations at key conferences in endocrinology

ea0086op3.4 | Reproductive and Neuroendocrinology | SFEBES2022

Identification and characterisation of novel follicle-stimulating hormone receptor antagonists

Duyen Tran Hanh , Agwuegbo Uche , Albert Anthony , Jonas Kim

Follicle-stimulating hormone receptor (FSHR) is a Class A G protein-coupled receptor (GCPR) that is essential in reproduction. Interactions with its heterodimeric glycoprotein hormone, FSH, activates the cAMP/PKA signalling pathway, which induces steroidogenic activity and granulosa cell proliferation to support ovarian follicle growth and survival. Moreover, a number of ageing-related extragonadal roles of FSH/FSHR have been proposed, with menopausal elevation in FSH linked t...

ea0094oc4.6 | Reproductive Endocrinology | SFEBES2023

Tool development: Characterization of novel follicle-stimulating hormone receptor (FSHR) Inhibitors

Xu Ruijuan , Sureshkumar Sumetha , Agwuegbo Uche , Tran Hanh , Hopkins Thomas , Bousfield George , Jonas Kim

Follicle stimulating hormone (FSH) is a heterodimeric glycoprotein hormone, crucial for regulating female reproduction. Its actions are mediated through FSHR, a Class A G protein-coupled receptor (GPCR), which primarily couples to Gs/cAMP/PKA pathway to modulate ovarian follicle growth, granulosa cell proliferation, and estrogen production. In addition to dogmatic functions of FSH in reproduction, there is increasing evidence that FSH can act on extragonadal tissues. Specifica...