Searchable abstracts of presentations at key conferences in endocrinology

ea0019p116 | Diabetes, Metabolism and Cardiovascular | SFEBES2009

The effects of combined plant derived oleanolic acid and insulin on blood glucose concentration in streptozotocin-induced diabetic rats

Musabayane CT , Mapanga RF , Tufts MA , Oyedeji OO , Shode FO

We have previously attributed the hypoglycaemic effects of Syzygium cordatum leaf extract to crude ethyl acetate extract solubles (EAS) containing triterpenoid compounds. The present study was designed to isolate and characterize triterpene components EAS and investigate the antihyperglycaemic effects alone or in combination with insulin in non-diabetic and streptozotocin (STZ)-induced diabetic rats. EAS soluble extracts were obtained after defatting the S. cordatum<...

ea0019p124 | Diabetes, Metabolism and Cardiovascular | SFEBES2009

Renal effects of plant-derived oleanolic acid in streptozotocin-induced diabetic rats

Mapanga RF , Tufts MA , Shode FO , Musabayane CT

Previous studies from our laboratories indicate that the anti-diabetic effects of Syzygium cordatum (Hochst.) (Myrtaceae) leaf extract in streptozotocin-induced diabetic rats may be attributed in part to mixtures of triterpenes, oleanolic acid (OA) and ursolic acid (UA). For the bioactive compounds to have potential in diabetes management, they should also alleviate or prevent complications of diabetes mellitus; kidney function and cardiovascular disorders. This study i...