Searchable abstracts of presentations at key conferences in endocrinology

ea0014p283 | (1) | ECE2007

In vitro effects of 17 βE2 and raloxifene on desmoid tumour derived cells

Picariello Lucia , Sala Silvia Carbonell , Martineti Valentina , Gozzini Alessia , Brandi Maria Luisa , Tonelli Francesco

Desmoid tumours (DT) are a benign manifestation of familial adenomatous polyposis. The prevalent development in young fertile women, the regression during menopause or with tamoxifen treatment, underlie the potential role of estrogens and Estrogen Receptors (ERs) in the pathogenesis of these tumors. To investigate this hypothesis, the expression of ERs α and β in desmoid tumors derived cell cultures, the effects of 17βE2 and of raloxifene on DT cell p...

ea0014oc3.6 | Endocrine tumors & neoplasia | ECE2007

ERß-specific transcriptional profile in colon cancer

Martineti Valentina , Mascherini Massimiliano , Mavilia Carmelo , Sala Silvia Carbonell , Tognarini Isabella , Azzari Chiara , Stefanini Federico Mattia , Tonelli Francesco , Brandi Maria Luisa

Epidemiological data clearly evidence a protective role of estrogens against the development of colon cancer and ERβ has been identified as the predominant ER subtype in human colon. More recently it has been identified as a favourable prognostic marker in this disease, possibly explaining the protective effect of estrogens against colon cancer development. To understand the specific role and mechanism of action of ERβ in colon tumorigenesis we developed an in vit...

ea0014p284 | (1) | ECE2007

ESR2 genotypes are associated with a reduced relative risk for sporadic colorectal cancer

Martineti Valentina , Picariello Lucia , Del Monte Francesca , Valanzano Rosa , Strigoli Debora , Sala Silvia Carbonell , Canonico Giuseppe , Tonelli Francesco , Brandi Maria Luisa

According to incidence data from Italian cancer registers, colorectal cancer is the third most common cancer in both men and women even considering skin non-melanoma cancers, lung and breast cancers. Moreover it represents the third absolute leading cause of cancer death in women and the fourth in men. Although data on Italian population regarding the role of estrogens in colorectal cancer have not yet been collected, several strands of evidence from international epidemiologi...