Searchable abstracts of presentations at key conferences in endocrinology

ea0021p389 | Thyroid | SFEBES2009

TSH receptor antibody assay: its use in a tertiary centre

Theodoraki Aikaterini , Jones Gareth L , Perera Sithara , Patel Darshna , Parker Jennifer C , Bunn Chris C , Thomas Mike , Bouloux Pierre-Mark , Vanderpump Mark

Background: The BTA guidelines for the use of thyroid function tests recommend the measurement of TSH receptor antibodies (TRAb) when investigating hyperthyroidism of uncertain aetiology, in suspected Graves’ ophthalmopathy and in pregnant women with Graves’ disease. An in-house TSH receptor autoantibody ELISA assay (TRAb) was introduced in 2008. This study has audited the assay performance and evaluated its clinical usefulness in a tertiary centre.<p class="abst...

ea0044s10.2 | Clinical thyroidology update | SFEBES2016

Thyroiditis: Post-partum, subacute and new drugs

Vanderpump Mark

Destructive thyroiditis is characterised by hyperthyroidism due to release of pre-formed hormones. The increased concentration of thyroid hormone suppresses serum TSH. Radioactive iodine uptake is close to nil in all cases when hyperthyroidism is present. The duration of hyperthyroidism is generally 2–3 months and limited by the amount of thyroid hormone present. The ratio of serum T3:T4 is lower in destructive thyroiditis than in Graves’ disease. Hypothyroidism is c...

ea0038s1.2 | Endocrinology meets the environment | SFEBES2015

Iodine deficiency

Vanderpump Mark

Iodine is an essential component of the thyroid hormones thyroxine (T4) and triiodothyronine (T3) which play a crucial role in brain and neurological development. The ideal dietary allowance of iodine recommended by World Health Organisation (WHO) is 150 μg of iodine per day which increases to 200–250 μg/day in pregnancy. Severe iodine deficiency may be associated with impairment in the psycho-neurological outcome in the progeny because bot...

ea0028mte2 | (1) | SFEBES2012


Vanderpump Mark

Amiodarone has been used widely for treating resistant tachyarrhythmias in the past three decades. It is an iodinated benzofuran derivative with a structural formula that closely resembles that of thyroid hormones and contains about 37% of organic iodine by weight, from which 10% is deiodinated to yield free iodide. Given the daily maintenance dose of amiodarone between 100–600 mg daily, about 3.5–21 mg of iodide are released into the systemic circulation, equivalent...

ea0021cm2.1 | Endocrine incidentalomas: what to do with lumps and bumps | SFEBES2009


Vanderpump Mark

The aetiology of thyroid nodules is due to the interaction between genetic and environmental factors. Thyroid nodules are common. Epidemiological studies suggest that 1% of men and 5% of women have thyroid nodules detected clinically and that the frequency increases with age and in iodine-deficient populations. With the increasing use of sensitive imaging techniques, an increasing proportion of thyroid nodules are detected incidentally. Up to 50% of nodules >1 cm detected ...

ea0013d2 | This house believes that all patients with sub-clinical thyrotoxicosis should be treated | SFEBES2007

This house believes that all patients with subclinical thyrotoxicosis should be treated: Against the motion

Vanderpump Mark

Subclinical thyrotoxicosis, defined as a low serum thyrotrophin (TSH) and normal serum free T4 and T3 concentrations, has been found in up to 3.2% of adults in cross-sectional surveys of thyroid function, of whom 75% have serum TSH concentrations of 0.1 to 0.4 mU/L. If the diagnosis is limited to only those with a serum TSH lower than 0.1 mU/L, the prevalence decreases to 0.7%, with 20% being treated with thyroxine.Thyrotoxicosis is considered overt only...

ea0056s28.3 | Endocrinology Meets Immunology | ECE2018

Immunotherapy Related Endocrinopathies

Vanderpump Mark

Recent advances in immunology have resulted in the development of new classes of immune-modulatory therapy in the management of cancers and an increased overall survival for various cancers. Immune checkpoint direct antibodies block intrinsic down-regulators of immunity, such as cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed cell death 1 (PD-1) or its ligand, programmed cell death ligand 1 (PD-L1). As an inevitable consequence of increasing the activity of the immune...

ea0028p114 | Clinical practice/governance and case reports | SFEBES2012

Tolvaptan treatment for the syndrome of inappropriate antidiuretic hormone (SIADH): a case report

Meek Claire , Kaplan Felicity , Vanderpump Mark

Tolvaptan is an ADH antagonist licensed for the treatment of the syndrome of inappropriate ADH secretion (SIADH). We describe the case of a patient with severe symptoms due to refractory SIADH who was successfully treated with tolvaptan. A 35-year old patient developed a chordoma involving the pituitary gland and optic chiasm and was treated with surgery, radiotherapy and gamma knife therapy. After several years, she developed recurrent, severe, symptomatic hyponatraemia due t...

ea0034p395 | Thyroid | SFEBES2014

Clinical outcome of radioiodine treatment for Graves' disease at a tertiary care centre

Rathore Ali , Mathew Rammya , Garg Anukul , Vanderpump Mark

Objective: A review of the efficacy and safety of radioiodine treatment for Graves’ disease.Methodology: Patients were identified following a search of the nuclear medicine departmental database. Consecutive patients who had radioiodine in 3-year period from January 2009 to December 2011 were included in the audit. Information was obtained from medical notes, blood results and nuclear medicine database. Data was analysed using Microsoft Excel.<p...

ea0028oc3.7 | Obesity, thyroid and Addison's disease | SFEBES2012

Subclinical hypothyroidism is associated with fatigue and impaired functional status in males in the Whickham 20-year follow up cohort

Madathil Asgar , Razvi Salman , Vanderpump Mark , Pearce Simon , Weaver Jolanta

Introduction: The association between fatigue, functional status and subclinical hypothyroidism (SCH) remains unclear. The available data is not consistent, and this is likely to be due to selection bias in studies recruiting patients from clinic rather than unselected community populations. Only population surveys looking at prevalence of fatigue and functional status in SCH are likely to provide the answer.Objective and Methodology: We compared the pre...