Searchable abstracts of presentations at key conferences in endocrinology

ea0014gh1biog | Geoffrey Harris Prize Lecture | ECE2007

Geoffrey Harris Prize Lecture

Vaudry Hubert

Hubert Vaudry, France-. AbstractDr Hubert Vaudry is Director of Research at the Institut National de la Santé et de la Recherche Médicale (INSERM), the French National Institute for Health, and Director of the Laboratory of Cellular and Molecular Neuroendocrinology at the University of Rouen. He was born in February 1946 in Le Havre, Normandy, and obtained his PhD at the University of Rouen in 1974. He then ...

ea0014gh1 | Geoffrey Harris Prize Lecture | ECE2007

Neuroendocrine control of steroid biosynthesis within the hypothalamus

Vaudry Hubert , Do Rego Jean-Luc , Beaujean Delphine , Galas Ludovic , Larhammar Dan , Young Seong Jae , Luu-The Van , Pelletier Georges , Tonon Marie-Christine

Neuroactive steroids synthesized in the brain, referred to as neurosteroids, have gained particular attention as they appear to be involved in the modulation of various neuroendocrine, behavioral and pathophysiological processes. Thus, the distribution of steroidogenic enzymes and the identification of the biochemical pathways leading to neurosteroid formation have now been almost completely elucidated in various groups of vertebrates. In contrast however, the neuronal mechani...

ea0014s5.1 | Novel bioactive peptides – lessons from animals | ECE2007

Discovery of novel bioactive peptides: the uniquely important contribution of amphibians to mammalian neuropeptidology

Vaudry Hubert , Tostivint Hervé , Lihrmann Isabelle , Chartrel Nicolas , Fournier Alain , Leprince Jérôme , Tonon Marie-Christine , Conlon J. Michael

The concentration of many neuropeptides in the brains of ectothermic vertebrates is several orders of magnitude higher than in the brains of mammals. We have taken advantage of this singular situation to isolate from the brain of the European green frog, Rana esculenta, a number of regulatory peptides that are orthologous to mammalian neuroendocrine peptides. These include α-MSH, γ-MSH, two tachykinins, two GnRH variants, CRH, PACAP, NPY, CGRP, CNP, GRP, and O...

ea0014s8.1 | Advances in adrenal hypersecretory disorders | ECE2007

Autocrine-paracrine pathways in primary adrenal disorders

Lefebvre Hervé , Contesse Vincent , Cartier Dorthe , Perraudin Véronique , Delarue Catherine , Vaudry Hubert , Bertherat Jérôme , Plouin Pierre-François , Kuhn Jean-Marc , Louiset Estelle

It is now well demonstrated that, in the human adrenal gland, aldosterone and cortisol productions are stimulated by autocrine/paracrine factors, like serotonin (5-HT) and arginine vasopressin (AVP). Several data indicate that these signals may also be involved in the regulation of corticosteroidogenesis in adrenocortical hyperplasias and tumors. 5-HT is detected in clusters of steroidogenic cells in aldosterone-producing adrenocortical adenomas (APAs), and in both ACTH-indepe...