Searchable abstracts of presentations at key conferences in endocrinology

ea0065oc4.1 | Thyroid | SFEBES2019

A high-throughput yellow fluorescent protein (YFP) cell-based screen identifies autophagy modulators to increase the effectiveness of radioiodine therapy

Read Martin , Baker Katie , Fletcher Alice , Thornton Caitlin , Alshahrani Mohammed , Nieto Hannah , Khan Rashida , Webster Jamie , Haggie Peter , Verkman Alan , Alderwick Luke , Boelaert Kristien , Smith Vicki , McCabe Christopher

New targeted drug strategies are urgently needed to improve radioiodine uptake and efficiently ablate thyroid cancer cells thereby minimising the risk of recurrent disease. High-throughput screening (HTS) offers a promising approach to identify new candidate drugs that will induce sodium iodide symporter (NIS) function to promote iodide uptake. However, significant progress has been limited by a lack of thyroid cell-based assays amenable to HTS. Here, we constructed a thyroid ...