ea0059oc4.3 | Clinical highlights | SFEBES2018
Elder Charlotte
, Vilela Ruben
, Cross Alexandra
, Johnson Trevor
, Helen Kemp E
, Keevil Brian
, Wales Jerry
, Newell-Price John
, Ross Richard
, Wright Neil
Introduction: Worldwide the Short Synacthen Test (SST) is the most popular investigation for adrenal insufficiency (AI). Its invasivity make it resource-intensive. Salivary cortisol is a well-established alternative to serum. We have developed a non-invasive alternative to the SST, using a novel formulation of Synacthen (containing a drug enhancer, chitosan) administered nasally and utilising saliva to measure glucocorticoid response.Methods: Four open-l...