Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2018

Glasgow, UK
19 Nov 2018 - 21 Nov 2018

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The Society for Endocrinology BES will take place 19-21 Nov 2018 in Glasgow. Come and exchange knowledge, share experiences and strengthen collaborations across our global community of endocrinologists.

Oral Communications

Clinical highlights

ea0059oc4.1 | Clinical highlights | SFEBES2018

Targeted molecular analysis in adrenocortical carcinomas: a strategy towards improved personalized prognostication

Lippert Juliane , Appenzeller Silke , Liang Raimunde , Sbiera Silviu , Kircher Stefan , Altieri Barbara , Weigand Isabel , Riemens Renzo , Rosenwald Andreas , Kroiss Matthias , Rost Simone , Fassnacht Martin , Ronchi Cristina

Background: Adrenocortical carcinoma (ACC) has a heterogeneous prognosis and current medical therapies have limited efficacy in its advanced stages. Genome-wide multi-omics-studies identified molecular patterns associated with clinical outcome. Here, we aimed at identifying a molecular signature useful for both personalized prognostic stratification and druggable targets, using methods applicable in clinical routine.Methods: 117 tumor samples from 107 AC...

ea0059oc4.2 | Clinical highlights | SFEBES2018

Kisspeptin- a novel clinical test of hypothalamic function in men with hypogonadotrophic hypogonadism

Chia Eng Pei , Abbara Sophie Clarke Ali , Phylactou Maria , Mills Edouard , Koteshwara Muralidhara , Chia Germaine , Yang Lisa , Pratibha Machenahalli C , Papadopoulou Deborah , Izzy-Engbeaya Chioma , Jayasena Channa , Comninos Alexander N , Dhillo Waljit S

Background: Hypogonadotrophic Hypogonadism (HH) is characterised by hypogonadism in the context of low gonadotrophin levels, frequently due to a defect in hypothalamic function e.g. KallmanÂ’s syndrome. However, no direct test of hypothalamic function currently exists. Kisspeptin is a hypothalamic neuropeptide that stimulates endogenous GnRH release. Thus, we investigated whether kisspeptin could be used to interrogate hypothalamic function in men with HH.<p class="abs...

ea0059oc4.3 | Clinical highlights | SFEBES2018

A novel non-invasive short synacthen test validated in healthy adult and paediatric populations

Elder Charlotte , Vilela Ruben , Cross Alexandra , Johnson Trevor , Helen Kemp E , Keevil Brian , Wales Jerry , Newell-Price John , Ross Richard , Wright Neil

Introduction: Worldwide the Short Synacthen Test (SST) is the most popular investigation for adrenal insufficiency (AI). Its invasivity make it resource-intensive. Salivary cortisol is a well-established alternative to serum. We have developed a non-invasive alternative to the SST, using a novel formulation of Synacthen (containing a drug enhancer, chitosan) administered nasally and utilising saliva to measure glucocorticoid response.Methods: Four open-l...

ea0059oc4.4 | Clinical highlights | SFEBES2018

An intravenous insulin protocol designed for pregnancy reduces neonatal hypoglycaemia after betamethasone administration in women with gestational diabetes

Rowe Christopher , Putt Elise , Brentnall Olivia , Gebuehr Alison , Allabyrne Jackie , Woods Andrew , Wynne Katie

Introduction: Neonatal hypoglycaemia (NH) is common in infants born soon after betamethasone administration, and may be reduced by at-target peri-partum glycaemic control. A Pregnancy-specific Intravenous Insulin-Glucose Infusion (PIIGI) protocol was introduced at a tertiary hospital in June 2017, replacing a generic Adult IntraVenous Insulin protocol (AIVI) not designed for pregnancy, without change in indication for IV insulin (initiated with any BGL>6.7 mmol/L following...

ea0059oc4.5 | Clinical highlights | SFEBES2018

Hypothalamic-pituitary adrenal axis recovery rate of patients with glucocorticoid-induced adrenal insufficiency (GC-induced AI)

Feliciano Chona , Gleeson Helena , Tomlinson Jeremy , Nightingale Peter , Willets Matthew

Aim: To evaluate the recovery rate, characteristics and factors that might help predict the HPA axis recovery of patients with glomerulonephritis (GN) and GC-induced AI.Study Design: A retrospective study involving all GN patients referred from January 2014-December 2016 with a confirmed diagnosis of GC-induced AI with a planned weaning from conventional Prednisolone (Pred) immunosuppression and switch onto Hydrocortisone (HC). Data collected up to Novem...

ea0059oc4.6 | Clinical highlights | SFEBES2018

11C-Methionine PET/MRI is superior to MRI for localisation of functioning prolactinomas and may facilitate targeted intervention

Bashari Waiel , Powlson Andrew , Senanayake Russell , Sekaran Arvindh , Serban Laura , Koulouri Olympia , Gillet Daniel , Cheow Heok , Mendichovszky Iosif , Gurnell Mark

Background: Prolactinomas are the commonest hormone-secreting pituitary adenomas. First-line treatment is dopamine agonist (DA) therapy. However, side-effects are increasingly recognised, leading to an increasing consideration of transsphenoidal surgery (TSS) and/or radiotherapy. Co-registration of 11C-methionine Positron Emission Tomography (Met-PET) imaging with Spoiled Gradient Recalled Acquisition MRI (SPGR MRI), referred to in combination as Met-PET/MRI, can aid accurate ...