Endocrine Abstracts

Background: Growth is a multifactorial trait, in which about 80% are determined by genetic factors. The pituitary plays a central role and some of the transcription factors can be involved in isolated or combined deficits: they orchestrate the ontogeny of the gland, maintain the differentiated state and mediate the coordinated expression of specific cell type. Among them, LHX4 mutations can manifest as a combined pituitary hormone deficiency and are associated with an...