Searchable abstracts of presentations at key conferences in endocrinology
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26th European Congress of Endocrinology

Stockholm, Sweden
11 May 2024 - 14 May 2024

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We are pleased to announce that ECE 2024 will be held in Stockholm, Sweden from 11-14 May 2024. We will, once again, be offering the hybrid format next year so you can join us in person in Sweden or remotely with ECE@Home.

Eposter Presentations

Late Breaking

ea0099ep1226 | Late Breaking | ECE2024

Assessment of sarcopenia in patients with diabetes mellitus, considering body composition

Makhlina Elena , Navmenova Yana , Kononova Oksana , Mohort Tatiana

Objective: To assess the features of the manifestation of sarcopenia (SP) in patients with diabetes mellitus (DM), taking into account the body composition.Materials and study methods: The study included 87 patients with DM (29 men - 33% and 58 women - 67%). The average age of patients was 41.59±11.84 years and duration of diabetes was 12.51±6.39 years. The study included anthropometric measurements: mass body index (BMI), waist circumference (WC),...

ea0099ep1227 | Late Breaking | ECE2024

Patient perception of unmet needs for multiple endocrine neoplasia (MEN) in germany

Schubert Rosemarie , Bruegmann Petra , Grey Jo , de Graaf Johan , Fleischer Juliet , Schmelzer Helga , Drewitz Philipp , Schaaf Ludwig

The German Network for Pituitary and Adrenal Disorders (Netzwerk Hypophysen- und Nebennierenerkrankungen e.V.) conducted a nationwide survey on unmet needs of patients with multiple endocrine neoplasia (MEN) in Germany. The study aimed to identify unmet needs in patient care and quality of life, as well as potential areas for improvement.Methods: The survey was based on a questionnaire developed by the European MEN Alliance (EMENA) and was distributed by...

ea0099ep1228 | Late Breaking | ECE2024

Primary bilateral macronodular adrenal hyperplasia caused by a novel variant in the ARMC5 gene

Lopes-Pinto Mariana , M Travessa Andre , Paula Ricca Lacerda Nobre M Caetano Ema , Paula Barbosa Ana

Introduction: Primary Bilateral Macronodular Adrenal Hyperplasia (PBMAH) represents <2% of all causes of Cushing’s Syndrome (CS). Clinical course is insidious, with adrenal bilateral macronodules and gradual cortisol excess, only rarely presenting with overt CS. The pathophysiology remains unclear in most cases; however, pathogenic variants in the onco-supressor ARMC5 gene are described in 25-50% of PBMAH and may confer a more severe clinical course. <p class="abs...

ea0099ep1229 | Late Breaking | ECE2024

Steroidogenesis inhibitors in mild/subclinical cushing’s syndrome: results from a retrospective cohort of patients

Bavaresco Alessandro , Ceccato Filippo , Mazzeo Pierluigi , Lazzara Martina , Voltan Giacomo , Tizianel Irene , Mondin Alessandro , Barbot Mattia

Cushing’s syndrome (CS) is a severe disease associated with elevated morbidity and mortality rates, up to four times higher than those of general population. Whether the positive effects of cortisol-lowering medications is widely documented in overt CS cases, its impact on mild or subclinical CS remains unclear since limited clinical investigations have been performed in patients with subclinical hypercortisolism. In this study, we retrospectively analysed clinical data f...

ea0099ep1230 | Late Breaking | ECE2024

Audit on management of addison’s disease in pregnancy

Ahsan Masato , Bremner Emma , Todd Diane , Roy Chandrima , J Levy Miles , Gohil Shailesh , Reddy Narendra

Background: Primary adrenal insufficiency or Addison’s disease (AD) is characterized by glucocorticoid and mineralocorticoid deficiency due to lesion of the adrenal glands through different mechanisms (1). Addison’s disease is a risk factor for adverse maternal and neonatal outcomes. Close monitoring is required for these patients during the intrapartum and postpartum periods.(2)Objective: Retrospective evaluation of the management of Addison&#...

ea0099ep1231 | Late Breaking | ECE2024

Autoimmune endocrinopathies associated with the use of immune checkpoint inhibitors: a clinical case of a combination of isolated secondary adrenal insufficiency and diabetes mellitus

Ebanoidze Laura , Pigarova Ekaterina , Dzeranova Larisa , Przhiyalkovskaya Elena , Ibragimova Lyudmila

Introduction: Endocrinopathies are one of the most common autoimmune adverse events (AIAEs) causing severe toxic complications during the use of checkpoint inhibitor therapy (CPI).Clinical Case: A patient with complaints of hyperpigmentation of the skin of the back in August 2022 an excisional biopsy was performed and pigmented epithelioid cell melanoma with tumor growth along the resection margin was verified. In December 2022, CT revealed metastases in...

ea0099ep1232 | Late Breaking | ECE2024

Angiogenesis in benign and malignant thyroid pathologies based on the vascular endothelial growth factor (VEGF) and CD34 markers activities

Gvianishvili Tamuna , Gogiashvili Liana

Angiogenesis is critical for tumor growth and metastatic spread. Vascular Endothelial Growth Factor (VEGF) is the most potent inducer of neovascularization, and its increased expression is associated with worse clinical outcome in many diseases. The aim of our work was to evaluate the dynamics of VEGF and CD34 molecular morphology with Follicular Epithelial Dysplasia (FED) in Thyroid neoplasm and autoimmune pathology. These markers allow accuracy distinguishing between pseudon...

ea0099ep1233 | Late Breaking | ECE2024

Features of pregnancy after simultaneous pancreas-kidney transplantation in patient with type 1 diabetes mellitus (clinical case)

Yevloyeva Madina , Savitskaya Darya , Severina Anastasia , Trubitsyna Natalia , Shamkhalova Minara

Introduction: Simultaneous pancreas-kidney transplantation (SPKT) is the best way to restore normoglycemia and renal function in patients with type 1 diabetes mellitus (T1D) and end-stage renal disease (ESRD). Pregnant patients after SPKT are a high-risk group for adverse events/loss fetal and transplantation organs. These risks are significantly reduced due to pregnancy planning, regular monitoring of the woman and fetus condition with timely correction of immunosuppressive t...

ea0099ep1234 | Late Breaking | ECE2024

Patient with MEN1 gene deletion and the classic triad of MEN-1 components

Salimkhanov Rustam , Vishnyakova Victoria , Kim Ekaterina , Lavreniuk Anastasia , Eremkina Anna , Vizerov Timofei , Utkina Marina , Mokrysheva Natalia

Introduction: Multiple endocrine neoplasia syndrome type 1 (MEN-1) is an autosomal dominant disorder caused by germline mutations in the MEN1 gene encoding menin. MEN1 mutations are mainly represented by deletions/insertions, nonsense, splice site or missense mutations and can be detected by DNA sequencing. MEN-1 generally includes parathyroid, adenohypophysis, and pancreatoduodenal neuroendocrine tumors.Clinical Case: Patient S., 26-ye...

ea0099ep1235 | Late Breaking | ECE2024

Use of bidirectional Mendelian randomization to unveil the mutual associations of Helicobacter pylori infection and autoimmune thyroid diseases

Wang Kai , Zhang Qinnan

Previous observational studies found associations between Helicobacter pylori infection and autoimmune thyroid diseases (AITDs), but the causal nature of this association is still uncertain. We investigated the causal effect of 6 crucial antibodies against H. pylori on AITDs using a bidirectional Mendelian randomization (MR). We found anti-H. pylori OMP significantly increased the risk of hyperthyroidism and Graves’ disease (GD). In addition, ou...

ea0099ep1236 | Late Breaking | ECE2024

Insufficient bone mineralization to sustain mechanical load of weight in obese boys: a cross-sectional study

Emeriau fabienne , Jager Jessica Amsellemn , Natacha Bouhours-Nouet , Aurelie Donzeau , Stephanie Rouleau , Solene Rerat , Emmanuelle Labarre , Lucie Levaillant , Coutant Regis

Context: The increase in bone mineral content (BMC) and density (BMD) measured by dual-energy X-ray absorptiometry (DXA) in obese children may not sustain the mechanical load associated with weight, and the factors influencing bone mineralization are not well known.Objective: We described bone mineralization in overweight- obese (ow/ob) and lean (non-ow/non-ob) boys in relation to body composition.Methods: Cross-sectional study in ...

ea0099ep1237 | Late Breaking | ECE2024

Therapeutic options in the control of refractory hypercalcemia due recurrent parathyroid carcinoma: a case series

Spasskaya Olga , Kim Ekaterina , Salimkhanov Rustam , Lavreniuk Anastasiia , Eremkina Anna , Mokrysheva Natalia

Introduction: Parathyroid carcinoma (PC) is one of the rarest malignant endocrine neoplasms (0.005% of all oncological diseases). PC relapses in 40-60% cases. The severity of the disease is determined by life-threatening hypercalcemia. Surgery is the gold treatment standard of primary tumors and distant metastases, but if it is contraindicated there are few options to control life-threatening hypercalcemia.Case 1: A 36-year-old-woman with a recurrent par...

ea0099ep1238 | Late Breaking | ECE2024

Characteristics of prolactin macroadenomas:a cross-sectional analytical study of 40 cases

Ayechi Farah , Sayadi Hanene , abid sana , Naouar Raoua , Belkahla Ghassen , Ben Nsir Atef , Ben Amor Bilel , Hajji Ekram , Bayar Ines , Marmouch Hela , Khochteli Ines , Darmoul Mahdi , Martinez Tames Gema

Introduction: Macroprolactinoma is a rare pathology often considered benign. However, its singularity lies in its potential to become highly invasive, threatening both functional and vital prognosis by infiltrating surrounding structures.Patients and methods: We conducted a monocentric, cross-sectional, analytical study of patients followed for confirmed prolactinoma at the endocrinology-internal medicine and neurosurgery departments of the Fattouma Bour...

ea0099ep1239 | Late Breaking | ECE2024

Symptomatic hypocalcemia and hypomagnesemia in a 72 year-old woman, chronic user of pantoprazole

Hernandez-Lazaro Alba , Jose de Leon-Durango Ricardo , Santana-Ojeda Borja , Molinero-Marcos Inmaculada , Acosta-Calero Carmen , Arnas-Leon Claudia , Kuzior Agnieszka , Gonzalez-Diaz Paula , del Pino Perez-Garcia Maria , Javier Martinez Martin Francisco

Introduction and Objectives: Proton-pump inhibitors (PPI) are some of the most commonly prescribed drugs, and they are generally well tolerated. However, their long-term use has been associated with adverse effects such as acute interstitial nephritis, Clostridium difficile infection. pneumonia, and (controversially) bone fractures, cardiovascular disease and dementia. The acidification of the intestinal milieu may interfere with TRMP6-mediated active absorption of magnesium i...

ea0099ep1240 | Late Breaking | ECE2024

Exploring experiences of patients with adrenal insufficiency (AI) using parenteral hydrocortisone injection device to manage adrenal crisis: a qualitative interview study

Chua Aldons , Drake William , Yoeli Heather , Oyibo Patrick , Dashora Umesh , Till David , Cartwright Martin , Llahana Sofia

Background: Adrenal Insufficiency (AI) is an inadequate production of cortisol hormone from the adrenal glands. The most common form is secondary AI (suppression of the hypothalamic-pituitary-adrenal axis), with a prevalence of approximately 300 cases per million. Patients with AI require lifelong corticosteroid replacement, which poses a risk of a life-threatening adrenal crisis (AC) event. AC presents with low blood pressure, hypoglycaemia and even loss of consciousness. Thi...

ea0099ep1241 | Late Breaking | ECE2024

Graves’ disease following subacute thyroiditis: a rare occurrence

Basmacı Nergis , Hanife Oguz Seda

Background: Subacute thyroiditis (SAT) is typically a self-limiting condition, with patients usually returning to normal thyroid function after healing. However, very rarely, Graves’ disease (GD) may develop following SAT. Case presentation: A 50-year-old female patient presented to an outside internal medicine outpatient clinic with anterior neck pain, fatigue, and subclinical fever symptoms. Her medical history included a diagnosis of psoriatic ar...

ea0099ep1242 | Late Breaking | ECE2024

Clinicopathological features of inflamed rathkes cleft cysts: a case series

Hayes Annabelle , Low Julia , Shoung Nicholas , Fung Sebastain , McCormack Ann

Background: Rathkes cleft cysts (RCC) are present in up to 20% of autopsy studies but only a minority necessitate surgical treatment1. Inflammation of the RCC wall may act a trigger for disease progression, resulting in development of clinical symptoms and prompting investigation and surgical management2,3. The significance of inflammation of RCC is thought to be three-fold: the development of classical symptoms including headache, visual disturbance or p...

ea0099ep1243 | Late Breaking | ECE2024

Severe spontaneous long-lasting hypoglycaemia. Differential diagnostic challenges thorough a case report

Csitari Gergő , Varga Bettina , Simonyi Gabor

In our presentation we would like to demonstrate a complex case with severe spontaneous long-lasting hypoglycaemic episodes that were observed for more than 48-hours. Later the continuous parenteral glucose need was promptly ceased. A 78-years-old hypertensive non-diabetic patient came to our hospital with hypoglycaemic coma. His unconsciousness were cured prehospitally by parenteral glucose replacement. However hypoglycaemic comas (GCS 1-2-1) were observed several times in th...

ea0099ep1244 | Late Breaking | ECE2024

Improvement in albumin excretion in patients with type 2 diabetes mellitus labelled as metformin-intolerant after rechallenge with extender-release metformin

Maria Perez-Rivero Jennifer , Hernandez-Lazaro Alba , Jose de Leon-Durango Ricardo , Rios-Gomez Carlos , Santana-Ojeda Borja , Molinero-Marcos Inmaculada , Arnas-Leon Claudia , Acosta-Calero Carmen , Kuzior Agnieszka , Javier Martinez Martin Francisco

Introduction and Objective: Metformin is still a mainstay of treatment in patients with type 2 diabetes mellitus (T2DM), but in 10-25% of them there are persistent gastrointestinal disturbances that worsen their quality of life, lead to poor compliance and treatment withdrawal, and ultimately result in worse health outcomes. Extended-Release Metformin (XRM) is much better tolerated, and since 2005 is recommended in the well-respected British NICE guidelines for the treatment o...

ea0099ep1245 | Late Breaking | ECE2024

Cutaneous lymphoid hyperplasia in a male patient with type 3 polyglandular autoimmune syndrome - a rare association

Cosma Daniel , Silaghi Horatiu , Alina Silaghi Cristina

Cutaneous lymphoid hyperplasia (CLH) is a spectrum of benign conditions characterized by reactive B- and T-cell cutaneous lymphocytic infiltrates. The most common presentation of reactive CLH is as a solitary red skin papule, nodule, or plaque but 10–15% of patients present with more generalized or multifocal skin lesions. A 40-year old male, initially diagnosed with type 1 diabetes mellitus (DM), with a family history of autoimmune thyroid disease, vitiligo and type 2 DM...

ea0099ep1246 | Late Breaking | ECE2024

Insights into beckwith-wiedemann syndrome: exploring the clinical spectrum and tumor surveillance in four case reports

Tănasie Denisa-Isabella , Braha Elena , Procopiuc Camelia , Boboc Aura-Madalina , Iordachescu Carmen , Padure Adriana , Gherlan Iuliana

Introduction: Beckwith-Wiedemann Syndrome (BWS), a genetic imprinting disorder linked to 11p15, showcases overgrowth traits, including macrosomia, macroglossia, and abdominal wall defects. Characterized by specific genotype-phenotype correlations and recognized as a cancer predisposition syndrome (nephroblastoma, hepatoblastoma, neuroblastoma and adrenocortical carcinoma), our four case reports provide insights into varied clinical presentations.Case rep...

ea0099ep1247 | Late Breaking | ECE2024

Sociodemographic and socioeconomic factors of patients with adrenal insufficiency and their influence on glucocorticoid dosage and the occurrence of adrenal crisis

Haase Milena , Kropp Peter , Bullmann Catharina , Harbeck Birgit

Introduction: Patients with primary, secondary or tertial adrenal insufficiency are usually treated with a glucocorticoid substitution therapy adjusting dosages to align with the circadian rhythm. Despite those attempts, finding the correct dosage individually seems challenging, influenced not only by the complexity of circadian rhythms but also by various other factors. Approximately 6-8% of adrenal insufficiency patients still experience adrenal crises every year, which is a...

ea0099ep1248 | Late Breaking | ECE2024

Primary aldosteronism in patient with autosomal dominant polycystic kidney diseases: diagnostic and therapeutic challenge

Fatma Kammoun , Ben Nacef Ibtissem , Mekni Sabrine , Essayeh Sawsen , Laamouri Rihab , Mariem Werfili , Nadia Mchirgui , Khiari Karima , Rojbi Imen

Introduction: Hypertension is often associated with autosomal dominant polycystic kidney disease (ADPKD). The pathogenesis of hypertension is complex, including intrarenal activation of the renin-angiotensin-aldosterone system (RAAS), arterial stiffness endothelial dysfunction, increased sympathetic nervous system activity and endothelin-1 secretion. However a secondary cause of hypertension should be suspected in presence of hypokaliemia and resistant hypertension.<p clas...

ea0099ep1249 | Late Breaking | ECE2024

Prevalence and characterization of sexual dysfunctions in male patients with hyperprolactinemia in a national registry

De Fraia Antonio , Maseroli Elisa , Sbardella Emilia , de Angelis Cristina , Minnetti Marianna , Simone Auriemma Renata , Indirli Rita , Golinelli Caterina , Cignarelli Angelo , Vignozzi Linda , Corona Giovanni , Isidori Andrea , Pivonello Rosario

Hyperprolactinemia is frequently accompanied by sexual dysfunctions, represented by decreased libido, erectile dysfunction and ejaculatory disorders. Moreover, cabergoline (CAB), used for treatment of hyperprolactinemia, is known to influence sexual function. Aim of the study was to evaluate sexual function in males with hyperprolactinemia under medical therapy. Data were retrieved from GONADIS, a national registry on gonadal status and reproductive and psycho-sexual function ...

ea0099ep1250 | Late Breaking | ECE2024

Gonadis national registry on gonadal status in pituitary and adrenal disorders: prevalence and characterization of sexual dysfunctions in male patients with acromegaly

Garifalos Francesco , Feola Tiziana , Fralassi Noemi , De Angelis Cristina , Minnetti Marianna , Pirchio Rosa , Vignozzi Linda , Colao Annamaria , Corona Giovanni , Isidori Andrea , Pivonello Rosario

The potential independent role of growth hormone (GH) excess in sexual dysfunction of acromegalic male patients is poorly characterized. The aim of the current study was to evaluate the sexual function, in adult males with acromegaly, stratifying the cohort in “uncontrolled” and “controlled” disease. Data were retrieved from GONADIS, a national registry on gonadal status and reproductive and psycho-sexual function in patients affected by pituitary and adren...

ea0099ep1251 | Late Breaking | ECE2024

Nearly asymptomatic hypophosphatasia: a clinical case report

Pigarova Ekaterina , Asanova Aurika , Drachuk Elizaveta , Dzeranova Larisa

Introduction: Hypophosphatasia is a group of inherited disorders characterized by the impaired mineralization of bones and/or teeth and low serum alkaline phosphatase (ALP) activity. It is caused by a mutation in the ALPL gene encoding the isoenzyme of ALP resulting in a loss of function. Since an early age of onset is usually associated with a more severe disease, and a late age – with a mild course of the disease, the manifestation of the disorder ranges from a life-thr...

ea0099ep1252 | Late Breaking | ECE2024

Diagnosis of adult GHD: new diagnostic tests

Yuen Kevin

Although diminished height velocity and short stature are important clinical markers to consider testing for GHD in children, the signs and symptoms of GHD are not always so apparent in adults. Furthermore, quality of life and metabolic health are often impacted in adults with GHD; thus, making an accurate diagnosis is important so that appropriate GH replacement therapy can be offered to these patients. However, the diagnostic work up of adult GHD can be challenging and made ...

ea0099ep1253 | Late Breaking | ECE2024

Exploring the relationship between metabolic dysfunction-associated steatotic liver disease and osteoporosis

Pecani Marin , Miglionico Marzia , Mallamace Michele , Angeloni Gabriele , Barbitta Antonia , Basili Stefania , Andreozzi Paola

Background and aims: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Osteoporosis are two silent prevalent metabolic conditions. MASLD involves fat accumulation in the liver, along with at least one of five specified cardiometabolic criteria, while excluding other liver diseases or secondary causes. Osteoporosis is a systemic skeletal condition characterised by reduced bone mass, leading to increased fracture risk. The relationship between MASLD and decrea...

ea0099ep1254 | Late Breaking | ECE2024

Etiological profile of young diabetes mellitus in south indian population

Kamalanathan Sadishkumar , Rashmi Kg , Sahoo Jayaprakash , Naik Dukhabandhu , J Jabasteen , Chapla Aaron , Thomas Nihal

Background & objective: In contrast to Caucasians of European origin, the aetiology of diabetes mellitus (DM) in young adults in other ethnic groups, including Indians is likely to be heterogeneous and difficult to determine. This study was undertaken to determine the aetiology of DM in the young South Indian population. Methods: In this ambispective study, 144 South Indian young-onset diabetes (age at onset 12-35 years; duration <5 years) were s...

ea0099ep1255 | Late Breaking | ECE2024

A case of langerhans cell histiocytosis accompanying hypothalamus, mastoid bone and liver involvement

Acar Saadet , Cetinarslan Berrin , Canturk Zeynep , Selek Alev , Gezer Emre , Koksalan Damla , Alkan Ozlem , Oktem Fatma

Introduction: Langerhans cell histiocytosis (LCH) is a multisystem neoplastic disease with primarily bone and skin involvement. Although its pathogenesis is still not fully understood, LCH lesions contain clonal CD 207+ dendritic cells with the frequently identified BRAF V600E mutation and an inflammatory component. Although isolated central nervous system involvement is extremely rare, a common site of involvement is the hypothalamic-pituitary axis.Case...

ea0099ep1256 | Late Breaking | ECE2024

Factors associated with high glycemic variability in adolescents with type 1 diabetes

Mahjoub Faten , Bani Ines , Ben Amor Nadia , Mizouri Ramla , Henda Jamoussi

Factors associated with high glucose variability in patients with type 1 diabetes High glycemic variability is recognized as a risk factor for degenerative complications and hypoglycemia. The factors affecting glycemic variability in diabetic patients need to be clarified. Our aim was to determine factors associated with high GV in adolescents patients with type 1 diabetes.Method: This is a cross-sectional analytical study, conducted at the National Inst...

ea0099ep1257 | Late Breaking | ECE2024

«Is there disparity in gestational diabetes care in Switzerland?»

Kagi-Braun Nina , Alexander Kutz , Marie Lof

Background: Lifestyle interventions as well as pharmacological therapy are strong measures to prevent adverse pregnancy and birth outcomes in women with gestational diabetes (GDM). Social determinants of health and consequent health disparities can affect a successful GDM management. This includes inequality in health care and education quality, economic stability as well as environmental factors. However, in high-income countries, these social determinants of health have rare...

ea0099ep1258 | Late Breaking | ECE2024

Atypical manifestation of parathyroid carcinoma in patient with RET and CYP24A1 mutations: a case report

Asanova Aurika , Kim Ekaterina , Eremkina Anna , Pigarova Ekaterina , Mokrysheva Natalia

Introduction: Parathyroid carcinoma (PC) is one of the rarest endocrine malignancies. Most PCs are sporadic, sometimes occurring in the framework of familial primary hyperparathyroidism (PHPT). PHPT due to PC is usually characterized by significantly increased PTH levels, severe hypercalcemia, larger tumor size and a higher incidence of disease complications. Clinical case: A 56-year-old male C. presented with an accidental formation at the posterior con...

ea0099ep1259 | Late Breaking | ECE2024

Langerhans cell histiocytosis presenting spinal cord compression after diabetes insipidus diagnosis: a case report

Yarar Zeliha , Kaynak Hulya

Introduction: Langerhans cell histiocytosis (LCH) is a proliferative disease that origins from dentritic cell family. LCH most commonly affects bones and skin, but it can also involve the other systems and organs. Lytic bone lesions are the most common findings in LCH, LCH can involve any bone; the most common sites are skull and femur. In rare case, lytic osseous lesions occur in the spine. Diabetes insipidus (DI) is the most frequent endocrine abnormality associated with LCH...

ea0099ep1260 | Late Breaking | ECE2024

Papillary thyroid carcinoma revealed by toxic goiter: a case report

Azagouagh Hajar , Meryem Karimi , Dounia Talbi , Ghizlane Sebbar , Kaoutar Rifai , Hind Iraqi , Elhassan Gharbi Mohamed

Introduction: A toxic goiter is a goiter that functions autonomously, causing hypersecretion of thyroid hormones, and is almost always benign. We report here the case of a toxic goiter that revealed the presence of papillary thyroid carcinoma.Observation: Patient aged 68, with a history of arterial hypertension, followed for hyperthyroidism on a toxic goitre, with a thyroid scintigraphy showing an enlarged thyroid gland with intense uptake on the right s...

ea0099ep1261 | Late Breaking | ECE2024

Liver injury after I131 administration

Tica Irina

Hepatic effects of I131 administration in endocrine disorders are not mentioned in drug’s recipe and are rarely described in medical literature. We present the case of a 32 years old woman who was admitted and investigated for myalgias, arthralgias, asthenia and elevated transaminases (ALAT=482.22 UI/l). The patient was diagnosed in 2022 with autoimmune thyroiditis and a dominant nodule (TIRADS 4) in the right lobe. Thyroidectomy was performed in 2023 and multifocal, part...

ea0099ep1262 | Late Breaking | ECE2024

Clinical and biochemical characteristics of pheochromocytoma

Lugovskaya Anna , Ilovayskaya Irena

Introduction: Pheochromocytomas (PCCs) or adrenal paragangliomas are neuroendocrine non-epithelial catecholamine-producing tumors with a wide range of cardiovascular, metabolic, neurological manifestations, which may complicate the early diagnosis of the disease in some cases. Materials and methods: We analyzed data from 89 patients (58 women, 31 men, median age 52 years) with histologically and immunohistochemically verified PCCs including 4 patients wi...

ea0099ep1263 | Late Breaking | ECE2024

Nutritional status in patients with eating disorders after hospital admission

Lavinia Marginean Delia , Zurera Gomez Carmen , Angeles Galvez Maria , Rebollo-Roman Angel , Munoz Concepcion

Introduction: Eating disorders (ED) are prevalent psychiatric conditions with significant nutritional implications, posing a risk of life-threatening illness for patients. The chronic and recurrent nature of these disorders, along with normal laboratory test results, present challenges in their management and ongoing monitoring, which typically focuses on weight changes. Techniques like determining the phase angle using bioimpedance analysis or conducting functional muscle tes...

ea0099ep1264 | Late Breaking | ECE2024

Results of bariatric surgery in a third level hospital in the last 5 years

Torrecillas del Castillo Eduardo , Peinado Ruiz Mercedes , del Castillo Tous Romero Maria , Rave Garcia Reyes , Dominguez-Adame Lanuza Eduardo , Manuel Caceres Salazar Juan , Asuncion Martinez Brocca Maria

Aim: Describing bariatric surgery (BS) interventions in our center in the last five years, complications and effectiviness in weight loss and resolution of comorbities.Methodology: Prospective descriptive study on a cohort of people who underwent BS surgery at Virgen Macarena University Hospital, a tertiary hospital of the Public Health System of Andalusia, between January 2018 and May 2023. Patients who underwent revision surgery with a first previous s...

ea0099ep1265 | Late Breaking | ECE2024

Diagnostic challenges: suspected adrenal myeloid sarcoma

Hachani Kouloud , Mekni Sabrine , Essayeh Sawsen , Laamouri Rihab , Werfelli Meriem , Mchirgui Nadia , Khiari Karima , Rojbi Imen , Ben Nacef Ibtissem

Introduction: Myeloid sarcoma is a rare etiology of adrenal tumors, with both diagnostic and therapeutic difficulties. This clinical case highlights the diagnostic challenges inherent in the coexistence of these two pathologies, underscoring the complexity of their management.Case report: We present the case of a 40-year-old woman with a history of polycystic ovary syndrome since her youth. She was referred to our department to explore adrenal incidental...

ea0099ep1266 | Late Breaking | ECE2024

LHX4 mutation: new perspective

Munari Stefania , Vitella Rebecca , Gaudino Rossella , Antoniazzi Franco

Background: Growth is a multifactorial trait, in which about 80% are determined by genetic factors. The pituitary plays a central role and some of the transcription factors can be involved in isolated or combined deficits: they orchestrate the ontogeny of the gland, maintain the differentiated state and mediate the coordinated expression of specific cell type. Among them, LHX4 mutations can manifest as a combined pituitary hormone deficiency and are associated with an...

ea0099ep1267 | Late Breaking | ECE2024

The influence of hyperglycemia on clinical and biochemical parameters in patients with acute myocardial infarction

Rizaeva Mehriban , Shamansurova Zulaykho

Introduction: Hyperglycemia is often elevated in patients with acute myocardial infarction (AMI) and is a prognostic indicator. According to a number of researchers, the risk differs between women and men. The purpose of our study was to study the effect of hyperglycemia on clinical and biochemical parameters in men and women with AMI. Materials and methods: The study was conducted on 92 patients admitted to the intensive care unit of the cardiology cent...

ea0099ep1268 | Late Breaking | ECE2024

Using a SGLT2 inhibitor does not modify the efficacy and tolerability of extended-release metformin in patients with type 2 diabetes

Santana-Ojeda Borja , Hernandez-Lazaro Alba , Jose de Leon-Durango Ricardo , Molinero-Marcos Inmaculada , Kuzior Agnieszka , Arnas-Leon Claudia , Maria Perez-Rivero Jennifer , Martin-Perez Marta , Gonzalez-Diaz Paula , Javier Martinez Martin Francisco

Introduction and Objectives: The tolerance of extended-release metformin (XRM) is superior to that of conventional metformin. XRM is recently available in Spain as a fixed combination with sitagliptin, but not in monotherapy. There are no data yet on how additional antidiabetic treatment can modify the effects of the XRM/sitagliptin combination. After assessing the efficacy and tolerability of XRM/sitagliptin in patients with T2DM labelled as metformin-intolerant and treated w...

ea0099ep1269 | Late Breaking | ECE2024

Rechallenge with extended-release metformin in patients with type 2 diabetes labelled as metformin-intolerant: satisfaction and its determinants

Jose de Leon-Durango Ricardo , Hernandez-Lazaro Alba , Rios-Gomez Carlos , Santana-Ojeda Borja , Molinero-Marcos Inmaculada , Kuzior Agnieszka , Arnas-Leon Claudia , Maria Perez-Rivero Jennifer , Maria Garcia-Alamo Debora , Javier Martinez Martin Francisco

Introduction and Objectives: Extended-release metformin (XRM) is recently available in Spain as a fixed combination with sitagliptin, but not in monotherapy. Its tolerance is clearly superior to that of conventional metformin, and since 2005 the NICE guidelines for type 2 diabetes mellitus (T2DM) recommend its use in patients with metformin-caused gastrointestinal disturbances. We assessed the efficacy and tolerability of XRM/sitagliptin in patients with T2DM previously labell...

ea0099ep1270 | Late Breaking | ECE2024

Should acromegaly disease activity be considered while using anti-diabetic treatment among patients with acromegaly and diabetes?

Zaina Adnan , Sameer Kassem

Management of type 2 diabetes (T2DM) has advanced since introducing sodium-glucose co-transporter 2 inhibitors (SGLT2i) with their protective cardiovascular and renal effects. However, in acromegaly patients with diabetes, the SGLT2i class is less attractive among endocrinologists because of the increased risk of diabetic ketoacidosis (DKA), and the use of incretin-based therapy as second-line treatment after metformin is more considered. This review aims to discuss the role o...

ea0099ep1271 | Late Breaking | ECE2024

The short and long-term potential negative effects of thyroxine therapy in children and adolescents

Soliman Ashraf , Alaaraj Nada , Hamed Noor , Mohamed Shayma , Alyafei Fawzia

Introduction: This review aims to systematically analyze and summarize the findings from research articles regarding the potential short-term and long-term side effects of L-thyroxine therapy in children and adolescents. The selection criteria for the studies included their focus on the negative effects of thyroxine therapy related to thyroid health, cognitive function, cardiovascular health, bone health, and cancer risk in pediatric populations. Results...

ea0099ep1272 | Late Breaking | ECE2024

Dilated cardiomyopathy: an unusual revelation of autoimmune hypothyroidism; case report

Qasdi Ikrame , Ouirar Hasna , Elmoatamid Kaoutar , Toulali Fatima , Rifai Kaoutar , Hinde Iraqi , Elhassan Gharbi Mohamed

Introduction: The occurrence of Dilated Cardiomyopathy (DCM) and hypothyroidism induced systolic dysfunction is rare, especially when it presents as an initial manifestation of hypothyroidism Case We report the case of a 57-year-old patient, a known chronic smoker, who was admitted to the emergency department reporting asthenia, NYHA class III dyspnea, cardiac angina, and periorbital oedema. The ECG reveals a regular rhythm at 50 bpm and diffuse low voltage with firstdegree at...

ea0099ep1273 | Late Breaking | ECE2024

When an ectopic and hyperfunctional thyroid nodule appears 2 decades after subtotal thyroidectomy: A case report

Ouirar Hasna , Qasdi Ikrame , Zouna Caimae , Riad Amal , Elmoatamid Kaoutar , Toulali Fatima , Sabbar Ghizlane , Rifai Kaoutar , Hinde Iraqi , Elhassan Gharbi Mohamed

Introduction: A toxic thyroid nodule refers to a nodule that functions autonomously, causing an overabundance of thyroid hormones. It is generally considered non-malignant. Making a decision regarding surgery in hyperthyroid patients necessitates the accurate localization of the toxic region. Here we report a case of an intrathoracic toxic thyroid nodule causing hyperthyroidism with a normally functioning cervical thyroid nodule.Case: A 63 year-old femal...

ea0099ep1274 | Late Breaking | ECE2024

From high dose Insulin therapy to dual oral therapy: recovery from glucotoxicity after acute pancreatitis and severe ketoacidotic hyperglycaemia

Al Sahaf Hassan , AlMahrous Lama , Mohammed Azmi

Significant hyperglycaemia suppresses beta cell replication and cell cycle progression. Acute beta cell failure is caused by several mechanisms involving oxidative and endoplasmic stress leading to DNA damage response (collectively termed glucotoxicity) (1). Short-term glycaemic control unmasks the regenerative potential of beta cells, leading to recovery and potentially weaning off Insulin therapy (1, 2, 3). We present a case of a 62-year-old woman with ...

ea0099ep1275 | Late Breaking | ECE2024

Graves’ disease associated with primary biliary cholangitis: a case report

Meryem Karimi , Azagouagh Hajar , Ouirar Hasna , Kaoutar Rifai , Hind Iraqi , Elhassan Gharbi Mohamed

Introduction: Graves’ disease is an autoimmune thyroid disease that is frequently associated with other autoimmune diseases. In our case, we report a rare association with primary biliary cholangitis.Case report: A 38-year-old patient, with no particular medical history, has been followed for Graves’ disease for 14 years, initially treated with carbimazole with poor therapeutic compliance and irregular follow-up. The evolution was marked by the...

ea0099ep1276 | Late Breaking | ECE2024

A rare association between cushing’s disease and primary biliary cirrhosis: about a case report

Abid Arige , Najla Bchir , Benchhida Annam , Abderrahim Yosra , Dorraelguiche Dorra , Chadia Zouaoui , Ouertani Haroun

Introduction: Cushing’s disease is a rare disorder caused by the hypersecretion of corticosteroids. Primary biliary cirrhosis (PBC) is a chronic autoimmune cholestatic hepatopathy characterized by destruction of the bile ducts and the presence of m2-type anti-mitchondrial antibodies. We report a rare association between cushing’s disease and primary biliary cirrhosis.Observation: The patient was 38 years old, with recent history of d...

ea0099ep1277 | Late Breaking | ECE2024

Heterozygous type 1 familial hypercholesterolemia patient with a rare LDL receptor mutation and the efficacy of evolocumab in the management of consequent hyperlipidemia

Boskovic Olivera , Hubanic Edina

Heterozygous (monoallelic) familial hypercholesterolemia (HeFH) is a monogenic disorder that affects one in 300 people. The majority of cases of FH are caused by inherited mutations in the LDLR gene, which encodes the LDLR. Less commonly, the heterozygous FH phenotype can be caused by mutations in other genes, specifically PCSK9, which encodes proprotein convertase subtilisin/kexin type 9. As many as 30% of patients do not survive their first myocardial infarction (MI). We pre...

ea0099ep1278 | Late Breaking | ECE2024

Cardiovascular protection with a novel nutraceutical based on mulberry leaf, fenugreek, inulin, laciplantibacillus plantarum A14, chromium, zinc and niacin

Arnas-Leon Claudia , Maria Perez-Rivero Jennifer , Andrada-Diaz Sara , Hernandez-Lazaro Alba , de Leon-Durango Ricardo , Rios-Gomez Carlos , Santana-Ojeda Borja , Molinero-Marcos Inmaculada , Kuzior Agnieszka , Javier Martinez Martin Francisco

Introduction and Objectives: The prevalence of prediabetes in the adult Spanish population is close to 15%. People with prediabetes are not only at high risk of developing T2DM but also at high cardiovascular risk. Several drugs, including metformin, glitazones, GLP-1RAs and SGLT2is have been found to reduce the incidence of diabetes in this population, but none is currently licensed with this indication. In particular α-glucosidase inhibitors such as acarbose have been s...

ea0099ep1279 | Late Breaking | ECE2024

A rapid and concise dual-mode aptasensor for ultrasensitive detection of 17β-estradiol

Zhao Fengfeng

Objective: Pollution of endocrine disrupting chemicals has become a global issue. As one of the hormonally active compounds, 17β-estradiol produces the strongest estrogenic effect when it enters the organism exogenously including food intakes, bringing potential harmfulness such as malfunction of the endocrine system. Therefore, in order to assure food safety and avoid potential risks of 17β-estradiol to humans, it is of great significance to develop rapid, sensitive...

ea0099ep1280 | Late Breaking | ECE2024

Relation between hormonal and metabolic status in persons affected by the chnpp accident with parathyroid disordres

Praporschikova Valeriia , Muraviova Irina , Afanasyev Dmytro

Objective: assessment of endocrine system profile featuring hormonal and metabolic parameters in persons affected by the ChNPP accident with parathyroid disorders. Methods and results: Patients treated in the Department of Radiation Endocrinology in 2019-2020 were selected (n=150) by the method of blind sampling in accordance with the study objective. Study sample included the 100 subjects (50% females, 50% males) were affected by the ChNPP acci...

ea0099ep1281 | Late Breaking | ECE2024

Abstract withdrawn...

ea0099ep1282 | Late Breaking | ECE2024

Temporal and masseter muscle evaluation by MRI provides information on muscle mass and quality in acromegaly patients

Milioto Angelo , Corica Giuliana , Nista Federica , Campana Claudia , Arecco Anna , Mattioli Lorenzo , Belluscio Lorenzo , Ferone Diego , Tagliafico Alberto , Gatto Federico

The impact of GH/IGF-1 levels on skeletal muscle in patients with acromegaly is still matter of debate. Recently, temporal (TMT) and masseter muscle thickness (MMT) have emerged as reliable indicators of muscle mass, as well as patients’ functional status/prognosis in various clinical context – especially in the oncologic setting. This study aims to investigate the potential correlations between TMT/MMT and patients’ demographic and clinical characteristics. A r...

ea0099ep1283 | Late Breaking | ECE2024

Estimation of thyroid diseases in type 1 DM women living in iodine deficiency region

Makhkamova Mushtariy , Karimova Mukima , Ibragimova Nigora , Muhammadsiddikov Muhammadrasul , Shamansurova Zulaykho

Iodine deficiency diseases are one of the wide problems seen in the geografically iodine deficiency regions and associated with a large number of people. The goal of our investigation was study of frequency of the thyroid diseases in women with type 1 Diabetes Mellitus (DM1) whose living in Ferghana valley, the iodine deficiency region of Uzbekistan. Materials and methods: In 120 female patients in age from 18h to 36 years old with type 1 diab...

ea0099ep1284 | Late Breaking | ECE2024

Neurosurgery treatment for macroprolactinomas: a retrospective study

Naouar Raoua , Sayadi Hanene , Abid Sana , Belkahla Ghassen , Ben Nsir Atef , Ben Amor Bilel , Hajji Ekram , Bayar Ines , Marmouch Hela , Khochteli Ines , Darmoul Mahdi , Martinez Tames Gema

Introduction: The management of prolactinomas, whatever their size, is based on medical treatment with dopamine agonists (DA). The latter allows clinical improvement with efficient control of prolactin secretion and tumor growth. Pituitary surgery or radiotherapy are adjuvant therapies in case of neurologic complication or lack of response to DA.Patients and methods: We conducted a monocentric analytic study of patients followed for confirmed prolactinom...

ea0099ep1285 | Late Breaking | ECE2024

Impact of type 1 Diabetes on growth, puberty onset and retardation

Babamukhamedova Shakhnoza , Shamansurova Zulaykho

Introduction: In some cases pubertal growth and sexual maturation and relating normal physiology can be disturbed and retarded by chronic disease as like Diabetes Mellitus (DM). According to International Diabetes Federation Atlas in 2013 approximately 5, 00, 000 known cases of children with T1DM (0–14 years) worldwide, where 50-60% of cases are diagnosed before the age of 15. Insulin deficiency in T1DM presented with age in childhood and visible peaks at the time of pube...

ea0099ep1286 | Late Breaking | ECE2024

Diabetes mellitus and endometrial carcinoma: risk factors and etiological links

Karabaeva Zebo , Shamansurova Zulaykho

Introduction: Diabetes mellitus (DM) has emerged as a significant global health concern, contributing to increased mortality and complications, thereby adversely affecting overall quality of life. The incrising incidence of DM, particularly type-2 DM (T2DM), correlates with rising rates of various cancers, suggesting a potential direct link between DM and cancer. Mounting evidence suggests DM as a potential contributor to the heightened incidence of endometrial cancer (EC) and...

ea0099ep1287 | Late Breaking | ECE2024

Epidemiological, clinical, paraclinical, and preoperative complication of primary hyperparathyroidism: a moroccan single center experience

Zarraa Lamiae , El Amel Rania , Rouf Siham , Latrech Hanane

Introduction: Primary hyperparathyroidism is a common endocrinopathy associated with autonomous hypersecretion of PTH by one or more parathyroid glands. This work aims to study the epidemiological, clinical, biological, radiological, and therapeutic profile of primary hyperparathyroidism, as well as its preoperative complications.Material and methods: A retrospective descriptive study of 50 patients followed at the Endocrinology-Diabetology-Nutrition Dep...

ea0099ep1288 | Late Breaking | ECE2024

Hypocalcemia revealing digeorge syndrome: case report

Zakaria Cheibete , Cheikh Mariem , Elmoctar Mohamed

DiGeorge syndrome is a genetic abnormality caused by a microdeletion of chromosome 22. Chromosome 22q1 1.2 microdeletion was first identified in 1992 [1-3] as the common genetic anomaly associated with a range of conditions previously known as DiGeorge or velocardiofacial syndrome, usually presents later in childhood, often leading to hypernasal speech caused by cleft palate, submucous cleft palate, or velopharyngeal insufficiency. Both disorders share similar clinical feature...

ea0099ep1289 | Late Breaking | ECE2024

Leydig cell tumors in a postmenopausal women: case report

Fatma Kammoun , Mekni Sabrine , Essayeh Sawsen , Laamouri Rihab , Mariem Werfili , Nadia Mchirgui , Khiari Karima , Rojbi Imen , Ben Nacef Ibtissem

Introduction: Virilizing ovarian tumors (VOT) are a rare cause of hyperandrogenism in postmenopausel women. Leydig cell tumors (LCTs) are rare sex-cord stromal tumors as they account for less than 0, 1 % of all ovarian tumors, and although they occur at any age, approximately one-fourth of them present after menopause. We report a clinical case of Leydig cell tumor in a postmenopausal woman.Case-report: A 75-year-old woman, with a personnel history of ty...

ea0099ep1290 | Late Breaking | ECE2024

Diagnosis of MEN-1 syndrome with multiple tumor locations and a rare genetic mutation

Tsitsimpis Anastasios , Papadimitriou Kasiani , Papanikolaou Vasiliki , Rigana Maria , Barkas Konstantinos , Nastos Konstantinos , Vryonidou Andromahi

Introduction: Most of pituitary adenomas are sporadic, with only 5% of them attributed to genetic mutations and syndromes such as Multiple Endocrine Neoplasia type 1 (MEN-1). However, how easy is it for a doctor to suspect it when there is no known family history?Case Presentation: A 36-year-old patient with no personal or family history presented to our Endocrine Department reporting intermittent episodes of unconsciousness during the last 48 hours. The...

ea0099ep1291 | Late Breaking | ECE2024

Endocrine disorders associated with prader-willi syndrome: a case report

Cheikh Mariem , Elmoctar Mohamed , Zakaria Cheibete , Isselmou Diehah , Kaoutar Rifai , Iraqi Hinde , Mohamedelhassan Gharbi

Introduction: Prader Willi syndrome is a rare and complex genetic disease, with numerous implications on metabolic, endocrine, neurologic systems, with behavior and intellectual difficulties. Many patients with PWS manifest short stature due to growth hormone deficiency. These individuals also present with hypothalamic dysfunction, leading to several endocrinopathies such as hypogonadism, hypothyroidism, central adrenal insufficiency, with reduced bone mineral density. Our cas...

ea0099ep1292 | Late Breaking | ECE2024

Effectiveness of the transition process in adolescents with chronic endocrinological disorders: experience of the transition clinic in verona, italy

Munari Stefania , Gaudino Rossella , Vantini Sabrina , Ferruzzi Alessandro , Zoller Thomas , Arrigoni Marta , Castello Roberto , Antoniazzi Franco

Background: Literature data indicate that up to 36.8% of patients with chronic endocrinopathies, occurring in children, abandon follow-up visits in adulthood, with the risk of major long-term consequences for their health. For this reason, it is essential that their transfer to an adult physician takes place through a well-structured transition process in order to ensure continuity of care. With this goal, the Transition Clinic of pediatric endocrine pathologies of AOUI Verona...

ea0099ep1293 | Late Breaking | ECE2024

The impact of metabolic and hormonal alterations on sexual and psychological function in women with polycystic ovary syndrome

Verde Nunzia , Sorice Federica , Scairati Roberta , de Angelis Cristina , Garifalos Francesco , Menafra Davide , de Fraia Antonio , Santella Luigi , Mazzarella Alessandro , Simona Auriemma Renata , Colao Annamaria , Pivonello Rosario

The current study evaluated the impact of metabolic and hormonal alterations on sexual and psychological function in women with Polycystic Ovary Syndrome (PCOS). Fifty consecutive women aged 24.16&pm;5.97 years with a diagnosis of PCOS were recruited; metabolic and hormonal parameters were measured and questionnaires related to sexual function (Female Sexual Function Index-FSFI) and psychological traits (Middlesex Hospital Questionnaire-MHQ, Body Uneasiness Test A and B-BUT A ...

ea0099ep1294 | Late Breaking | ECE2024

Population characteristics of thyroid carcinoma in children and adolescents living in conditions of iodine deficiency in the republic of uzbekistan

Muratova Shakhlo , Sattorova Madina

Introduction: Thyroid cancer (TC) is a rare disease in childhood, with an incidence of 0.2 to 5 cases per million per year or higher [Neiva F., 2012, Tuli G, 2023]. The incidence of malignancy among thyroid nodules in children is about 16%, which is about three times higher than in adults [Vaisman F., 2011, Yeker R.M., 2022]. Lymph node metastases (40–80%) and distant metastases (25%) are also much more common in the pediatric population [Zirilli G., 2018, Thomas JK., 202...

ea0099ep1295 | Late Breaking | ECE2024

Evaluation of body image and eating behavior disorders in pregnant women

Hasni Yosra , Saafi Wiem , Mlayah Aya , Elfekih Hamza , Chelly Syrine , Ghardallou Meriem , Lassoued Latifa

Introduction: During pregnancy, women experience various physiological changes that can impact them psychologically. Lifestyle modifications such as eating behaviors and physical activity during this period are major determinants of pregnancy outcomes, child development, and maternal health. Also, body transformations during this period could reactivate concerns regarding body image and introduce anxiety, body dissatisfaction, and eating behavior issues. The aim of our study w...

ea0099ep1296 | Late Breaking | ECE2024

Case report: acute intestinal pseudo-obstruction as a rare complication of pheochromocytoma

Yi Aung Yi , Man Li Ching , Ghieth Sherif

Phaeochromocytoma is a rare tumour of the adrenal gland medulla characterized by excess catecholamine release. Classic presentation includes paroxysms of hypertension and adrenergic symptoms such as headache, sweating, shortness of breath, and tachycardia. In severe cases, patients might develop hypertensive crises and cardiomyopathy. We present a case of intestinal pseudo-obstruction as a rare complication of phaeochromocytoma which responded only to surgical resection of the...

ea0099ep1297 | Late Breaking | ECE2024

The efficacy of pasireotide treatment in invasive crooke’s cell corticotropinoma – case report

Maliszewska Katarzyna , Poplawska-Kita Anna , Januszewska-Gilis Aleksandra , Witek Przemyslaw , Lyson Tomasz , Kretowski Adam

Introduction: Crooke’s cell adenomas (CCA) are a rare type of pituitary neoplasm, associated with Cushing’s disease. They are characterised by accumulation of perinuclear cytokeratin filaments, appearing distinctly hyaline in hematoxylin and eosin (HE) staining (Crooke’s hyaline change). Due to their rarity, the management and treatment remain a challenge.Clinical case: A 33-year-old male patient, presented sudden visual impairment, no sig...

ea0099ep1298 | Late Breaking | ECE2024

Primary hyperparathyroidism secondary to parathyroid carcinoma in a 53 year-old male presenting with lassitude, constipation and bone pains: a case report

Mae Pableo Rhoda , Bless Lumanlan-Mosqueda Donnah

Parathyroid carcinoma is a rare (<1-5%) cause of primary hyperparathyroidism (pHPT) marked by excessive parathyroid hormone secretion leading to hypercalcemia. The prevalence rate of parathyroid carcinoma is 0.005% among all malignancies which has a slow and indolent course. A 53 year old male presented with lassitude, constipation, and bone pains which are common but non-specific symptoms. Diagnostic examination showed ionized calcium of 2.16mmol/l, nephrolithiasis, eleva...

ea0099ep1299 | Late Breaking | ECE2024

Unraveling the link: polycythemia and hyperparathyroidism - a case report

Qamar Sulmaaz , Khoo Bernard

Introduction: This case report explores the intricate relationship between polycythemia and hyperparathyroidism in a 42-year-old male, shedding light on the resolution of polycythemia following surgical intervention for PTH-dependent hypercalcemia. Despite the absence of symptomatic nephrolithiasis or renal failure, the patient’s DXA scan revealed osteoporosis, prompting a deeper investigation into the complex interplay between these two conditions. <p class="abstext"...

ea0099ep1300 | Late Breaking | ECE2024

Thyroid cyst infected with capnocytophaga canimorsus

Cadogan Sinead , McQuaid Siobhan

Infected thyroid cysts are a rare complication of the thyroid gland, with haematogenous spread from a distal site of infection believed to be one mechanism of infection. We report the case of a patient who presented with an infected thyroid cyst due to Capnocytophaga canimorsus bacteraemia after sustaining a dog bite on her hand. A 37-year-old female presented to the Emergency Department with a five-day history of fevers, neck pain, and a rapidly enlarging neck swelling. The p...

ea0099ep1301 | Late Breaking | ECE2024

Autoimmune polyglandular syndrome type 2: a clinical case of a rare combination of primary adrenal insufficiency and latent autoimmune diabetes in adults

Katsobashvili Ilana , Ebanoidze Laura , Golodnikov Ivan , Dzeranova Larisa , Pigarova Ekaterina , Nikonova Tatyana

Introduction: According to statistical data, the combination of chronic adrenal insufficiency and diabetes mellitus is the rarest among patients with autoimmune polyglandular syndrome type 2 (APS-2).Clinical Case: In 2017, a 32-year-old patient B. with excess body weight manifested type 2 diabetes mellitus with typical clinical symptoms of carbohydrate metabolism disorder. Metformin and gliclazide were recommended. After a viral pneumonia episode with ho...

ea0099ep1302 | Late Breaking | ECE2024

Denosumab, immobility and calcium dysregulation

Minhas Raisa , Qureshi Asjid

Case Summary: We report a case of a 79 yr old female with multiple co-morbidities including diabetes mellitus, hypertension, recurrent TIAs, CABG (2015), HfpEF and osteoporosis. Following treatment for the latter with Denosumab 60 mg, the patient developed hypocalcaemia (1.87 -2.13 mmol/l) with appropriately raised PTH (7.2 - 457.4 pmol/l). Her 25 hydroxy vitamin D level was 99 nmol/l. Her hypocalcaemia was managed with alfacalcidol and intravenous and then oral ...

ea0099ep1303 | Late Breaking | ECE2024

The effect of teriparatide on bone density in osteoporotic patients with hiv infection

Palioura Eleni , Herolidi Eleni , Kalogeris Nikolaos , Dermentzoglou Alexandros , Katsafyloudi Maria , Konidaris Alexandros , Tsekes Georgios , Chini Maria , Vryonidou Andromahi

Introduction: HIV infection has been associated with bone loss and increased frequency of bone fractures. The main pathogenetic mechanisms involve the direct effect of the virus and the HIV-induced inflammatory cytokines on bone metabolism, the effect of antiretroviral therapy (cART) per se and the frequently coexisting nutritional disorders and hypogonadism, further accelerating bone loss. Bisphosphonates remain the first-line treatment for these patients. Limited da...

ea0099ep1304 | Late Breaking | ECE2024

Efficacy and side effects of subcutaneous pasireotide alone or in combination with cabergoline in patients with cushing’s disease whithout postoperative remission

Selek Alev , Demir Nurgul , Cetinarslan Berrin , Canturk Zeynep , Gezer Emre , Sozen Mehmet , Koksalan Damla , Alkan Ozlem , Acar Saadet , Oktem Fatma

Pasireotide is a second-generation, multireceptor-targeted somatostatin receptor ligand and is approved for the treatment of patients with Cushing’s Didease (CD) for whom surgery has failed or is not an option. This retrospective single center study aims to report the efficacy, side effects and follow-up of the treatment with pasireotide alone or in combination with cabergoline in patients without remission after transsphenoidal surgery. Among 187 patients with CD, 15 pat...

ea0099ep1305 | Late Breaking | ECE2024

Diabetes as a consequence of chronic calcifying pancreatitis: case report

Qasdi Ikrame , Ouirar Hasna , Riad Amal , Zouna Caimae , Toulali Fatima , Sabbar Ghizlane , Rifai Kaoutar , Hinde Iraqi , Elhassan Gharbi Mohamed

Introduction: Diabetes stemming from pancreatic causes constitutes 0.5% of diabetes cases (1–2). It is defined as ’other specific types of diabetes resulting from exocrine pancreas impairment.’ Through this case report, we elucidate the distinctive clinical features of chronic calcifying pancreatitis-related diabetes. Case report: A 31-year-old male with a diabetic family history and a history of occasional alcohol consumption, is presenti...

ea0099ep1306 | Late Breaking | ECE2024

Changes in gut microbiota and arginine metabolic rates in patients with type 1 diabetes

Aghajanova Yelena , Melkonyan Arthur , Alchujyan Nina , Gayane Bayburdyan , Arakelyan Lusine , Hakobyan Sona , Gevorgyan Zara , Zohrabyan Naira , Hovhannisyan Margarita , Mnatsakanyan Armine , Vardanyan Anna

Introduction: Type 1 diabetes (T1DM) is one of the most frequent autoimmune and metabolic disorders in childhood and youth, developing due to autoimmune destruction of β-cells, which leads to an absolute insulin deficiency. Accumulating data suggest that gut microbiota (GM) may contribute to the pathogenesis of diabetes influencing the immune response, in which arginine-metabolizing enzymes are involved, particularly arginase. We examined the connection between GM and cyt...

ea0099ep1307 | Late Breaking | ECE2024

Hypocalcemia revealing digeorge syndrome: case report

Cheikh Mariem , Zakaria Cheibete , Mokhtar Mohamed , Rifai Kaoutar , Hinde Iraqi , Elhassan Gharbi Mohamed

Introduction: DiGeorge syndrome is a genetic abnormality caused by a microdeletion of chromosome 22. Chromosome 22q1 1.2 microdeletion was first identified in 1992 as the common genetic anomaly associated with a range of conditions previously known as DiGeorge or velocardiofacial syndrome.Case report: A 17-year-old Moroccan male was mildly mentally challenged and had seizures from the age of 9 years. He had dysmorphic facial features, and mild tortuosity...

ea0099ep1308 | Late Breaking | ECE2024

Thyroid replacement therapy with liquid levothyroxine as an alternative for patients with gastrointestinal absorption problems

Torrecillas del Castillo Eduardo , Peinado Ruiz Mercedes , Rodriguez de Vera Pablo , Torres Cuadro Alberto , Garcia Socorro Clara , Asuncion Martinez Brocca Maria , Martin Hernandez Tomas

Aim: Illustrating a case series of two patients with levothyroxine malabsorption and suboptimal control of the thyroid profile who experienced a significant improvement after switching to liquid levothyroxine.Material and Methods: Case saries of two patients who were attended in monographic thyroid pathology consultations at Virgen Macarena University Hospital.Results: Case 1: a 46-year-old female patient who had multinodular goitr...

ea0099ep1309 | Late Breaking | ECE2024

Malignant pheochromocytoma unmasked by paralyzing sciatic symptoms: a case report

Ouirar Hasna , Zouna Caimae , Qasdi Ikrame , Elmoatamid Kaoutar , Toulali Fatima , Sabbar Ghizlane , Rifai Kaoutar , Hinde Iraqi , Elhassan Gharbi Mohamed

Introduction: Developing in the adrenal medulla’s chromaffin cells, pheochromocytoma (PC) is an infrequent tumor Illustrating the instance of a patient diagnosed with malignant adrenal pheochromocytoma (PCM) following the onset of paralyzing sciatic painCase: A 60-year-old patient managing hypertension with triple therapy and type 2 diabetes using metformin and insulin glargine. The patient sought emergency care due to recurrent and disabling sciati...

ea0099ep1310 | Late Breaking | ECE2024

Somatotropinoma masked by morbid obesity: a case report

Averkina Anastasia , Guseinova Raisat , Rafaelyan Manushak , Vasukova Olga , Andreeva Elena , Pigarova Ekaterina , Azizyan Vilen , Bondarenko Ekaterina , Kopytina Daria , Mokrysheva Natalia

Introduction: Acromegaly can be asymptomatic for a long time and morbid obesity can mask typical clinical signs (facial disfigurement, large hands and feet) and even severe disorders, such as hypopituitarism, cardiomyopathy, respiratory dysfunction, sleep apnea, atherosclerosis, endothelial dysfunction, arthropathy, prediabetes/diabetes, dyslipidemia and mineral dysmetabolism. Menstrual irregularity and infertility combined with headaches are among the earliest issues a patien...

ea0099ep1311 | Late Breaking | ECE2024

High levels of serum prolactin associated with antipsychotic use: Should we be concerned? About two cases

Mraihi Emna , Rojbi Imen , Mekni Sabrine , Essayeh Sawsen , Laamouri Rihab , Werfelli Meriem , Khiari Karima , Ben Nacef Ibtissem

Introduction: Antipsychotic-induced hyperprolactinemia is a prevalent hindering condition that is often overlooked. It is responsible for several significant consequences that alter the patients’ therapeutic compliance and quality of life. It can be a debilitating condition that warrants routine assessment and careful management through well-structured protocols. Case details: We report the case of two patients treated with antipsychotics: -The firs...

ea0099ep1312 | Late Breaking | ECE2024

Improvement of blood pressure in patients with type 2 diabetes, labelled as metformin-intolerant when rechallenged with extended-release metformin

Kuzior Agnieszka , Maria Perez-Rivero Jennifer , Arnas-Leon Claudia , Hernandez-Lazaro Alba , Jose de Leon-Durango Ricardo , Santana-Ojeda Borja , Molinero Marcos Inmaculada , Acosta-Calero Carmen , del Pino Perez-Garcia Maria , Javier Martinez Martin Francisco

Introduction and Objective: Extended-release metformin has much better gastrointestinal tolerability than conventional (immediate release)metformin and according to the UK NICE guidelines should be offered to patients who have gastrointestinal tolerance issues with conventional metformin. We rechallenged patients with T2DM labelled as metformin-intolerant and treated with a DPP4i with a single-pill combination (SPC) of extended release metformin and sitagliptin (1000/50 mg) in...

ea0099ep1313 | Late Breaking | ECE2024

Papillary thyroid microcarcinoma revealed during surgical treatment of squamous cell carcinoma of the larynx

Meryem Karimi , Azagouagh Hajar , Dounia Talbi , Kaoutar Rifai , Hind Iraqi , Elhassan Gharbi Mohamed

Introduction: The association of thyroid carcinoma with squamous cell carcinoma of the larynx is very rare, with few clinical cases reported in the literature.Case report: We report the case of a 63-year-old patient with no significant medical history who presented with progressive dysphonia. Fiberoptic examination revealed a budding lesion. CT scan showed a tumor process centered on the right vocal cord, with negative extension findings. The patient und...

ea0099ep1314 | Late Breaking | ECE2024

Characteristics of ferritin status in patients with NAFLD and insulin resistance

Kozak Olha , Hospodarskyy Ihor , Prokopchuk Oksana

Introduction: Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent pathologies in the modern world. Despite the prevalence of this pathology, it continues to be studied, with new facts and mysteries about this diagnosis emerging. One such aspect is the impact of NAFLD on serum ferritin levels.Aim: To investigate whether NAFLD affects serum ferritin levels in patients with insulin resistance.Materials and Methods: ...

ea0099ep1315 | Late Breaking | ECE2024

Renal cell carcinoma, solitary fibrous tumor and papillary thyroid carcinoma: an exceptional association

Yesmine Elloumi , Houcem ElOmma Mrabet , Younes Ayadi , Mariem Ayadi , Fadia Boubaker , Najoua Lassoued , Baha Zantour , Wafa Alaya , Habib Sfar Med

Introduction: The solitary fibrous tumor is a rare spindle cell neoplasm, originally described in the pleural cavity. However, it can occur in other locations. Multiple primary cancers are a rare entity and their incidence is described at 5.5%. We report a case associating three neoplasms: a renal cell carcinoma, a mediastinal solitary fibrous tumor and a papillary thyroid cancer.Obervation: We report the case of a 38 year old patient with no particular ...

ea0099ep1316 | Late Breaking | ECE2024

Clinical case of idiopathic osteoporosis associated with pregnancy

Katsobashvili Ilana , Ebanoidze Laura , Pigarova Ekaterina , Dzeranova Larisa , Vorotnikova Svetlana

Introduction: According to published data, pregnancy-associated osteoporosis is a rare disease, the pathophysiology of which is currently not fully explored.&Scy;linical case: In 2014, a 27 year-old patient B. after the first childbirth, pain appeared in the lumbosacral spine, for which a course of physical therapy was carried out with a short-term positive effect. In 2016 after the second childbirth, pains increased; according to the results of further ...

ea0099ep1317 | Late Breaking | ECE2024

Concomitant multiple myeloma in a patient with primary hyperparathyroidism

Somogyi Anna , Berta Eszter , Lengyel Inez , Varoczy Laszlo , Nagy Endre , Bodor Miklos

Introduction: Primary hyperparathyroidism (PHPT) is one of the most common causes of non-neoplastic hypercalcemia with characteristically increased or inappropriately normal plasma parathyroid hormone (PTH) levels. Hypercalcemia is also a significant feature of patients with multiple myeloma (MM), and a pathogenetic link is presumed between the two diseases, strengthened by preclinical data. Only limited number of case reports of concomitant PHPT and MM are available in the li...

ea0099ep1318 | Late Breaking | ECE2024

Hypocalcemia revealing digeorge syndrome: case report

Cheibete Zakaria , Cheikh Mariem , Elmoctar Mohamed

Introduction: DiGeorge syndrome is a genetic abnormality caused by a microdeletion of chromosome 22. Chromosome 22q1 1.2 microdeletion was first identified in 1992 as the common genetic anomaly associated with a range of conditions previously known as DiGeorge or velocardiofacial syndrome.Case report: A 17-year-old Moroccan male was mildly mentally challenged and had seizures from the age of 9 years. He had dysmorphic facial features, and mild tortuosity...

ea0099ep1319 | Late Breaking | ECE2024

Peculiar case of post-gastrectomy noninsulinoma pancreatogenous hypoglycemic syndrome

Ilić Saša , Popovic Bojana , Gostiljac Drasko , Milic Gordana , Pekic Djurdjevic Sandra , Miljic Dragana , Ristic Masa , Dimitrijevic Sreckovic Vesna

For the diagnosis of hyperinsulinemic hypoglycemia (HH), it is necessary that in symptomatic hypoglycemia in the fasting test the insulin/glucose ratio is >0.3, or that in spontaneous hypoglycemia there are C-peptide >0.6 nmol/l and insulin >3.0 mIU/ml. It is a well-known fact about the increasing frequency of hypoglycemia after bariatric surgery (estimated up to 30% of patients), mostly within the Dumping syndrome, but the frequency of occurrence of noninsulinoma ...

ea0099ep1320 | Late Breaking | ECE2024

in vitro study of 17-beta-estradiol effects on a renal cancer cell line

Rossi Lucrezia , Rosaria Ambrosio Maria , Chiara Zatelli Maria

Introduction: Renal carcinomas (RCs) are the most common kidney cancers, and their prognosis is affected by many factors; 5-year survival rate is >90% in patients with small tumors confined to the kidney. RC makes up 2-3% of cancers in adults aged between 50 and 70 years; in particular, the incidence in men is higher than women, 66.7 vs 33.3% of the cases, respectively. Aim: RC incidence is twice as high in men as in women. This difference could sugg...

ea0099ep1321 | Late Breaking | ECE2024

Possible concurrence of primary aldosteronism with cushing’s disease: a case report

Becheanu Diana , Mariana Ghemigian Adina , Stanescu Laura , Bucur Bianca , Petrova Eugenyia , Cocolos Andra

Resistant hypertension of endocrine cause can make for a challenging diagnosis but it certainly is a very important one.Case report: We present the case of a 65 year old male patient with a history of arterial hypertension and hypokalemia for the past 10 years, for which he was prescribed a combination of alpha and beta blockers, calcium channel blockers, angiotensin receptor blockers (ARBs), loop diuretic, and spironolactone. The lack of response to thi...

ea0099ep1322 | Late Breaking | ECE2024

Primary hyperparathyroidism meets vascular malformation: a tale of intriguing coexistence

Kassi Nada Ait , Hiba Kouira , Jade Issouani , Ahmed Anas Guerboub

Introduction and importance: Primary hyperparathyroidism is a prevalent source of hypercalcemia, predominantly attributed to a solitary adenoma in 80-85% of cases. Progress in imaging techniques has enhanced the accurate preoperative identification and targeted removal of hyperfunctional parathyroids in primary hyperparathyroidism (PHPT). The amalgamation of imaging methods or a "dual" approach, when congruent, enhances the precision of adenoma localization. Surgery re...

ea0099ep1323 | Late Breaking | ECE2024

Quality of life improvement associated with the rechallenge with extended-release metformin in patients with type 2 diabetes labelled as metformin-intolerant

Molinero-Marcos Inmaculada , Hernandez-Lazaro Alba , Jose de Leon-Durango Ricardo , Rios-Gomez Carlos , Santana Ojeda Borja , Kuzior Agnieszka , Arnas-Leon Claudia , Maria Perez-Rivero Jennifer , del Pino Perez-Garcia Maria , Javier Martinez Martin Francisco

Introduction and Objectives: The tolerability of extended-release metformin (XRM) is clearly superior to that of conventional metformin, with the potential to improve patient compliance, effectiveness and outcomes. Since 2005 the NICE guidelines for type 2 diabetes mellitus (T2DM) recommend its use in patients with metformin-caused gastrointestinal disturbances. XRM is recently available in Spain as a fixed combination with sitagliptin, but not in monotherapy. We assessed the ...

ea0099ep1324 | Late Breaking | ECE2024

Endocrine osteoporosis: report of a series of cases

Mohammed Amine Essafi , Hayat Aynaou , Houda Salhi

Background and aims: Endocrine osteoporosis should be uncommon in contemporary times due to improved early diagnosis of endocrinopathies. Our objective is to analyze the osteodensitometric profiles of patients under endocrinopathy care.Methods: A cross-sectional study of patients followed for endocrinopathies at the Endocrinology Department of the Hassan II University Hospital of Fez, spanning from the beginning of January 2016 to January 2022. Exclusion...

ea0099ep1325 | Late Breaking | ECE2024

Special case: giant invasive macroprolactinoma complicated by cerebrospinal fluid rhinorrhea and meningoencephalitis

Martinez Tames Gema Abid Sana , Sayadi Hanene , Ayechi Farah , Naouar Raoua , Belkahla Ghassen , Ben Nsir Atef , Ben Amor Bilel , Hajji Ekram , Bayar Ines , Marmouch Hela , Khochteli Ines , Darmoul Mahdi , Martinez Tames Gema

Introduction: Prolactinomas are the most commun secreting adenomas of the pituitary gland. They are classified according to their sizes into microprolactinomas (<10mm long axis) and macroprolactinoma (>=10mm long axis). According to studies its prevalence is approximately 3.5-5 for 100000 inhabitants. The diagnosis is made by the blood prolactin assay as well as the pituitary magnetic resonance imaging (MRI) which is the radiological reference exam to evaluate the dime...

ea0099ep1326 | Late Breaking | ECE2024

Pasireotide induced diabetic ketoacidosis in a patient with secondary diabetes with acromegaly

Patel Nishchil , Flanagan Daniel

Background: We report this interesting case of worsening diabetes and diabetes ketoacidosis in a young male with acromegaly who was commenced on Pasireotide treatment.Case Report: This 30 years gentleman was diagnosed with Acromegaly in April 2015. He underwent trans- sphenoidal surgery in January 2016 with significant residual tumour post-surgery. His IGF1 remained elevated and was unresponsive to Lanreotide. He was commenced on adjuvant therapy with Pa...

ea0099ep1327 | Late Breaking | ECE2024

Early gestational diabetes vs late gestational diabetes: are there any differences?

Garaizabal Azkue Leire , Larranaga Unanue Ihintza , Magdalena Arteaga Ossa Maria , Etxaniz Cerezo Ainhoa , Bravo Ansorena Celia , Unamuno Lecuona Maite

Whether frequency of complications during pregnancy increases when gestational diabetes (GD) is diagnosed early (<24 weeks) compared to late (>24 w) is not fully define. Observational studies suggest fasting glucose values (>92 mg/dl) during the first trimester are associated with adverse perinatal outcomes.Objectives: describe the characteristics of pregnant women with GD, the frequency of complications during pregnancy and delivery and asse...

ea0099ep1328 | Late Breaking | ECE2024

Latvian health professionals’ knowledge of diabetes mellitus and safe driving: a survey

Elīna Bērziņa Katrīna , Rasa Ingvars

Background: Hypoglycemia refers to blood glucose levels dropping below 4.0 mmol/l, which can cause dizziness and confusion in those with diabetes. In severe cases, patients may experience seizures, vision problems, and cognitive impairment. It is unsafe to drive while in this state of mind. Health professionals (HP) must possess the necessary expertise to educate patients on this matter and ensure their safety. Aims: The current study aimed to investigat...

ea0099ep1329 | Late Breaking | ECE2024

A case of HARS2-related perrault’s syndrome

Al-Qaysi Amina , Kyaw Yuyu , AlAjaimi Janan

Introduction: Amenorrhea is a frequent cause of Endocrinology clinic attendances. While causes like menopause, thyroid disorders and hyperprolactinemia are common, less common aetiologies need to be considered, especially the inherited ones that could affect a patient’s family. Identifying rare conditions requires constant vigilance, as well as clinical experience and the knowledge of the diagnostic criteria.Case report: We report the case of a 39-y...

ea0099ep1330 | Late Breaking | ECE2024

Primary hyperparathyroidism related to mediastinal ectopic parathyroid adenoma: about 2 cases

Zarraa Lamiae , Rouf Siham , Latrech Hanane

Introduction: Primary hyperparathyroidism is a frequent endocrinopathy characterized by a disorder of phosphocalcic metabolism related to an inappropriate secretion of parathyroid hormone (PTH). Parathyroid adenoma can be located ectopically and represents a particular diagnostic and therapeutic challenge. We report 2 clinical cases of ectopic parathyroid adenoma in mediastinal location.Observations: Case 1: A 47-year-old patient without...

ea0099ep1331 | Late Breaking | ECE2024

Diabetes and depression -a cyrculus vitiosus: case report

Popovic Pejicic Snjezana , Pejicic Nina , Soldat Stankovic Valentina , Malesevic Gabrijela , Jankovic Pejicic Anja

Introduction and aim: Depression has a strong impact on psychosocial as well as medical outcomes in patients with diabetes. Consequently, depression treatment in diabetes is also aimed at improvement of glycemic control and reduction of diabetes complications and mortality risk\. Up to now, no single treatment that consistently leads to better medical outcomes in patients with both depression and diabetes has been clearly identified.Matherial and methods...

ea0099ep1332 | Late Breaking | ECE2024

A case of combined PTH-dependent and PTH-independent hypercalcemia

Danilova Larisa , Korolenko Galina , Bourko Irina , Lushchyk Maxim , Ramanouski Alexei

Patient D., 74 years old, suffering from type 2 diabetes mellitus, was urgently taken to hospital No. 10 in Minsk with complaints of weakness, nausea and dry mouth. On admission glycemia was 26 mmol/l. Laboratory examinations revealed elevated levels of urea - 34.5 mmol/l, creatinine - 238.2 µmol/l, calcium - 3.12 mmol/l, extremely low levels of vitamin D - 4.8 ng/ml, high levels of parathyroid hormone - 101.3 pg/ml. The laboratory ratio of calcium and parathyroid hormone...

ea0099ep1333 | Late Breaking | ECE2024

A case report of a patient with severe postoperative hypoparathyroidism

Milotić Marina , Fabris Vitković Daniela , Babarović-Jurišić Mariza , Blagonić Aleksandra , Ferjančić Manuela , Milotic Marina

Beckgrounds and aims: The most common cause of hypoparathyroidism is postoperative, i.e., after thyroid, parathyroid, or radical neck surgery due to neoplasms, and is most often transient, whether continuous or even intermittent. The incidence of permanent hypoparathyroidism ranges from 0.8 to 3.0% in patients after total thyroidectomy. In this case report, we will present a patient with a severe form of postoperative hypoparathyroidism refractory to standard treatment regimen...

ea0099ep1334 | Late Breaking | ECE2024

Severe hypomagnesemia: outpatient management in endocrinology and nutrition unit

Maria Moyano-Sanchez Ana , Rebollo-Roman Angel , Carmen Serrano Laguna Mª , Jesus Calanas Continente Alfonso , Jose Molina Maria , Angeles Galvez Moreno Maria

Magnesium disorders are common in clinical practice. Hypomagnesemia is seen in inherited disorders, with excessive gastrointestinal or renal losses and due to medications. Replacement of magnesium can be challenging, with oral replacement strategies being generally more effective at slowly replacing body storages and intravenous (iv) replacement being more effective at treating life-threatening and severe cases of hypomagnesemia.Objective, material and m...

ea0099ep1335 | Late Breaking | ECE2024

Adipsic central diabetes insipidus as a result of neurosarcoidosis

Milosheska Radmila , Mickovski Ivana , Buklioska Ilievska Daniela

Background: Sarcoidosis is a multisystemic disease, the cause of which has not yet been determined. It’s characterized by the appearance of granulomas, which typically target the lungs, the lymphatic system and in rare cases, around 5-15%, changes in the nervous system are observed. Neurosarcoidosis leads to hypothalamus-pituitary axis dysfunction and the most common clinical manifestation is the onset of central diabetes insipidus.Case report: We p...

ea0099ep1336 | Late Breaking | ECE2024

An uncommon cause of high gonadotropins and testosterone in a 53-year-old male

Mathiopoulou Maria , Iris Romay Maria , Mavromanoli Anna , Bucher Martin , Schneiter Roger

A 53-year-old male was referred to the endocrinology outpatient clinic due to elevated levels of gonadotropins and testosterone (LH 11.7 IU/l, reference range 1.7-8.6 IU/l; FSH 17.7 IU/l, reference range 1.5-12.4 IU/l; testosterone 40.9 nmol/l, reference range 6.68-25.70 nmol/l; free testosterone 712.7 pmol/l, reference range 163-473 pmol/l) noted during an annual urologic check-up. No spermiogram was performed, and testicular ultrasound showed no abnormalities. The patient re...

ea0099ep1337 | Late Breaking | ECE2024

Sarcoidosis and hypothalamohypophyseal insufficiency: a case report

Azagouagh Hajar , Dounia Talbi , Meryem Karimi , Ghizlane Sebbar , Kaoutar Rifai , Hind Iraqi , Elhassan Gharbi Mohamed

Introduction: Sarcoidosis is a multisystem inflammatory disease. Hypothalamic-pituitary involvement in sarcoidosis is rare and poorly described. We report here a case of pituitary insufficiency during sarcoidosis disease.Observation: Patient aged 49 years, followed for systemic sarcoidosis with cutaneous, pulmonary and ocular tropism for 7 years, admitted for exploration of a severe polyuro-polydipsic syndrome with four nocturnal awakenings, questioning ...

ea0099ep1338 | Late Breaking | ECE2024

Rethinking how we classify pituitary tumours: insights from a serious case of prolactinoma

Bashari Waiel , Mohammed Azmi

Prolactinomas are a common type of pituitary tumours, making up about 40% of these tumours in total, with an estimated occurrence of 40-50 people per 100, 000. They are more common in women, especially during their reproductive years, but they can affect anyone at any age. Although most prolactinomas are small and respond well to treatment, around 2-10% are aggressive, growing into nearby areas like the cavernous sinus or sphenoid bone. The World Health Organisation’s 201...

ea0099ep1339 | Late Breaking | ECE2024

Pediatric pituitary microadenomas: a spectrum of clinical presentations and therapeutic responses"

Hamed Noor , Alaaraj Nada , Mohamed Shayma , Alyafei Fawzia , Soliman Ashraf

Pituitary microadenomas in children and adolescents are relatively rare, accounting for a small percentage of pediatric endocrine disorders. These benign tumors often present a diagnostic challenge due to their subtle and variable clinical manifestations at this young age. We present clinical and lab data of 5 children with pituitary microadenoma. Case 1: A 12-year-old female with a history of short stature and slow growth velocity was diagnosed with a small pituitary microade...

ea0099ep1340 | Late Breaking | ECE2024

Features of diagnosis and treatment of fulminant hypercortisolism due to ACTH-producing pheochromocytoma: a clinical case

Ebanoidze Laura , Pigarova Ekaterina , Beltsevich Dmitry , Sheve Anastasia , Dzeranova Larisa , Sitkin Ivan , Tarbaeva Natalya , Khairieva Angelina , Degtyarev Michail , Bondarenko Ekaterina

Introduction: Statistical data show that in the etiological structure of ACTH-ectopic syndrome pheochromocytoma occupies one of the last places in terms of frequency of occurrence (from 2.8 to 5.6%) Its manifestations such as adrenal mass with ACTH-dependent hypercortisolism lead to significant difficulties in establishing the correct diagnosis.Clinical Case: A patient with clinical manifestations of hypercortisolism underwent laboratory testing in Octob...

ea0099ep1341 | Late Breaking | ECE2024

Autoimmune polyendocrinopathy type 2 associated with celiac disease: a case report

Azagouagh Hajar , Meryem Karimi , Dounia Talbi , Ghizlane Sebbar , Kaoutar Rifai , Hind Iraqi , Elhassan Gharbi Mohamed

Introduction: Autoimmune polyendocrinopathies (AEP) are rare diseases defined by the presence of at least two endocrine deficiencies linked to an autoimmune mechanism, sometimes with an associated non-endocrine autoimmune disease. Autoimmune polyendocrinopathy type 2 is a more common syndrome, appearing mainly in adults.Observation: We report the case of a 27-year-old patient, admitted for management of acute inaugural adrenal decompensation, with a hist...

ea0099ep1342 | Late Breaking | ECE2024

Mayer-rokitansky-kuster-hauser syndrome: a cause of primary amenorrhea not to be ignored !

Dounia Talbi , Ikrame Qasdi , Ahmed Anas Guerboub

Introduction: Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare congenital cause of primary amenorrhea, characterized by aplasia of the vagina with or without concurrent uterine and/or cervical aplasia. MRKH syndrome has a heavy psychological impact, and requires multidisciplinary management.Case Report: A 17-year-old female patient presented for exploration of a primary amenorrhea. Her medical history was significant for recurrent urinary tr...

ea0099ep1343 | Late Breaking | ECE2024

Ovarian steroid cell tumor: a case report

Elmoctar Mohamed , Cheikh Mariem , Zakaria Cheibete , Kaoutar Rifai , Iraqi Hinde , Gharbi Mohamedlhassan

Introduction: Ovarian steroid cell tumors are very rare, and are endowed with steroid-secreting capacity. Most often, they are virilizing. Ovarian steroid cell tumours NOS, even if are rare, should be considered in any case of hyperandrogenism and excluded if elevated androgens levels are present. Our case illustrates this exceptional entity.Case report: A 47-year-old female presented with virilism associated with severe hirsutism, frontotemporal baldnes...

ea0099ep1344 | Late Breaking | ECE2024

Causal relationship between rheumatoid arthritis and hypothyroid state in young females in iodine deficiency area

Kurambaeva Diyora , Shamansurova Zulaykho , Burkhanova Maftunakhon

Introduction: In hypothyroidism bone turnover and osteoclastic resorption will be reduced which also aggravates Rheumatoid arthritis (RA) symptoms. In the literature shown data about relationship between RA and thyroid dysfunction. We aimed to discuss some possible causes and triggers that interplay in both conditions based on data from the literature.Material and methods: Data analysis was done using the systematic search performed in PubMed, MEDLINE, S...

ea0099ep1345 | Late Breaking | ECE2024

Third nerve palsy spontaneously resolved in diabetic patient

Zone Imen , Jallouli Aida , Rekik Mona , Sahli Meriem , Haj Kacem Akid Faten , Mejdoub Nabila , Amira Trigui

Introduction: We report a case of pupil sparing third nerve palsy caused by diabetes. Case Presentation: A 68-year-old woman consulted for acute left upper lid ptosis appeared since 2 days ago. The patient complained of blurred vision and periorbital pain. No history of head trauma or infection was reported. The patient has been diagnosed with type II diabetes mellitus and arterial hypertension since 15 years. Ophthalmological examination revealed comple...

ea0099ep1346 | Late Breaking | ECE2024

An uncommon manifestation of a common problem

Shoaib Zaidi Muhammad

Background: The commonest etiology for the chronic kidney disease and end-stage renal disease, universally, is diabetes. Although, the histology of the kidney is the gold standard for diagnosing diabetic kidney disease, but in common practice it’s usually diagnosed clinically and through laboratory testing.Clinical Case: 43 yrs old Saudi house-wife was admitted on the 7th of February, 2024 with 5 months history of progressive pitting pedal edema, fa...

ea0099ep1347 | Late Breaking | ECE2024

Frequency of major clinical syndromes in patients with drug-induced liver injury

Prokopchuk Oksana , Danchak Svitlana , Hospodarskyy Ihor , Kozak Olha , Gavryliuk Nadiia

Drug-induced liver injury (DILI) today is a global problem in modern gastroenterology and is increasingly common worldwide, demanding focused attention and in-depth study, particularly in terms of recognizing the major clinical syndromes. These often complicate the course of DILI and as a result, its correction.Objective: To investigate the frequency of major clinical syndromes in patients with DILI during chemotherapy with normal and excess body weight....

ea0099ep1348 | Late Breaking | ECE2024

Mild hypercalcemia and osteoporosis in a patient with breast cancer: case report

Matejkova Behanova Magdalena , Libansky Petr , Personova Kateřina , Vcelak Josef , Procykova Kristyna , Vlcek Petr

Introduction: The most common causes of hypercalcemia are primary hyperparathyroidism and malignancy. Malignancy-related hypercalcemia occurs in approximately 20% - 30% of all cancer patients during their clinical course and mainly affects patients with solid tumors such as breast carcinoma.Case Report : 57 yrs old woman was referred for hypercalcemia and osteoporosis. Laboratory: calcium 2.8 mmol/l (normal range 2.15 - 2.55) calculated ionized calcium 1...

ea0099ep1350 | Late Breaking | ECE2024

Association of parkinson’s disease in a patient with graves’ disease

Sandhu Faizan , Tahir Chohan Muhammad , Kamal Abouglila

Introduction: Parkinson’s disease is considered as a second most common neurodegenerative disorder but rarely associated with the Graves’ disease. Case report: A 44-year-old female diagnosed as Graves’ disease having classical features of hyperthyroidism i.e. tremors of hands, palpitations, weight loss despite of good appetite and biochemical evidence of thyroid function tests (TFTs) i.e. raised free T4, low TSH and positive antibodies. She was given car...

ea0099ep1351 | Late Breaking | ECE2024

Graves’ orbitopathy: Ocular manifestations and management

Zone Imen , Jallouli Aida , Haj Kacem Akid Faten , Rekik Nabila , Amira Trigui

Introduction: Graves’ orbitopathy is an inflammatory autoimmune disorder. It is the most common extrathyroidal manifestation of Graves’ disease and it is the leading cause of proptosis in adults. We report 3 cases of Graves’ orbitopathy in order to detail ocular manifestations and protocol management in this disease.Observation 1: A 63-year-old woman was referred for left conjunctival redness. The best-corrected visual acuity was 10/10 in ...

ea0099ep1352 | Late Breaking | ECE2024

Researching of the relationship between the numberof t regulatory cells and serum arachidonic acid level in autoimmune thyroiditis patients

Cagiltay Eylem , Bukrek Cengiz , Duygu Kırkık , Hacımustafaoğlu Fatih

Objective: Autoimmune Thyroid Disease (AITD) is a common disease, accounting for 1-4% of the overall episode. Regulatory T Cells are a substructure of CD4+ T cells that have received great attention for their role in maintaining tolerance by suppressing the growth response and preventing autoimmune diseases. Arachidonic Acid is found in cell membrane phospholipids and is the lipid mediator affected by the inactivation of bacteria. We aimed to determine the change in Regulatory...