Endocrine Abstracts

The clinical efficacy of strict glucose control against risk of diabetic macrovascular complications, despite effective treatment, has been disappointing, pointing to non-glucose related etiologic factors. Elevated inflammatory advanced glycation end products (AGEs), or Glycotoxins, known to increase the incidence and severity of diabetic complications, are recently shown to impair insulin production and insulin actions, hence are involved in the etiology of diabetes and insul...

Introduction: Advanced glycation end products (AGEs) formation is accelerated in various pathological conditions characterized by insulin resistance (IR) and/or increased oxidative stress (OS). Hypothyroidism – overt (OH) or subclinical (SUH) – is associated with a variety of metabolic disorders leading to IR and increased OS.Aim: To estimate the εN-carboxymethyl-lysine (CML) levels, in subjects with OH and SUH and seek f...